Dear CCP4bb, If you are a talented and motivated postdoctoral structural biologist, or soon to be, or know somebody who is…
Project Title: Structure and function of the essential M2-1 protein of human respiratory syncytial virus Our laboratories are interested in understanding the structural and cellular biology of a variety of negative strand RNA viruses. One of these viruses is human respiratory syncytial virus (HRSV), which is the leading cause of lower respiratory tract illness in young children and the immunocompromised, and has been linked to adult asthma. We recently determined the first X-ray crystal structure of the HRSV M2-1 protein, which is an essential transcriptional anti-terminator (Tanner et al., PNAS, 2014). The current project seeks to further understand the essential role of M2-1 in viral mRNA transcription, and will involve both X-ray crystallography and cell biological approaches using live recombinant virus and genome analog analysis. You will have a PhD (or be close to completion) in Structural Molecular Biology or a closely allied discipline, together with a proven track record of protein structure solution using X-ray crystallography. Experience of working with viruses in mammalian cell culture is highly desirable. University Grade 7 (£30,728 - £36,661 p.a.) Due to funding limitations an appointment will not be made above £30,728 p.a. Informal enquiries may be made to either Dr John N. Barr, email j.n.b...@leeds.ac.uk<mailto:j.n.b...@leeds.ac.uk> or Dr Thomas Edwards, email t.a.edwa...@leeds.ac.uk<mailto:t.a.edwa...@leeds.ac.uk>. Closing Date: 13 February 2014 http://jobs.leeds.ac.uk/fe/tpl_universityofleeds01.asp?s=4A515F4E5A565B1A&jobid=108922,2351796198&key=9056137&c=344787029814&pagestamp=sedylihlceulaesvjp Ed T.A.Edwards Ph.D. Deputy Director Astbury Centre for Structural Molecular Biology Ass. Professor, School of Molecular and Cellular Biology Garstang 8.53d University of Leeds, Leeds, LS2 9JT Telephone: 0113 343 3031 http://www.fbs.leeds.ac.uk/staff/tae/ http://www.astbury.leeds.ac.uk/people/staff/staffpage.php?StaffID=TE http://www.fbs.leeds.ac.uk/staff/profile.php?un=bmbtae Live as if you were to die tomorrow. Learn as if you were to live forever. Mahatma Gandhi
