Hi All
I'm curious the effect of small impurities in commercially synthesized
compounds on ITC and its analysis. Say if compound Y is the high
affinity binder, but you make a derivative that differs from a single
functional group from Y (you used Y to make this new compound) and you
Hi,
If your are talking about proteins or protein subunits, this means that you are
making polymers of nY, and Y becames the monomer. So in this case, I will not
consider Y as an impurity.
If I get you right, then size exclusion chromtography is good option to
separate the monomers from
Dear colleagues,
I would like to draw your attention to an upcoming educational webinar to
be presented by Paul Adams titled Structure Solution and Refinement with
Phenix which is scheduled to occur Thursday, August 26th at 10:00 PDT
(13:00 PM EST /17:00 UTC/GMT). You can find more
Hi,
I have an undergraduate student collecting information for the development of a
database of sulfur-SAD phased structures including data collection and other
experimental parameters for his semester project. Since mining the PDB for
this information has proven difficult I am asking members
Hi All,
I have a question for those of you familiar with the TLSMD webserver. I am
working on a structure with slightly imperfect 3-fold rotational NCS. My most
recent .pdb file has been generated using Refmac (followed by a little
tinkering in Coot), and during refinement I have been imposing
Dear Micheal,
As you say, the effect is probably arising from the different packing
environment of your NCS-related molecules.
Once you've taken TLS groups into account NCS restraints might even
perform better.
Cheers,
Roberto
On 24 Aug 2010, at 21:15, Michael Thompson wrote:
Hi All,
I
Senior Scientist/ Principal Scientist Membrane Protein Chemistry (Takeda
San Diego)
https://takedapharm.taleo.net/servlets/art.product.recruiterwebtop.Main
OperatorServlet?art_ip_action=RequisitionListnextFrame=JRLList#
If there is an interest in being considered further for the
