Re: [ccp4bb] Quote source inquiry

2020-07-14 Thread Eleanor Dodson 
True but who would claim it was

On Tue, 14 Jul 2020 at 21:22, Bernhard Rupp 
wrote:

> Hi Fellows,
>
>
>
> afaicrimps (as far as I can recall in my progressing senility)  someone
> once wrote/stated/cursed somewhere that “Macromolecular refinement is not a
> small molecule structure determination method”.
>
>
>
> Any citable source - George Sheldrick might be a suspect…
>
>
>
> Thanks & best regards, BR
>
>
>
> --
>
> Bernhard Rupp
>
> http://www.hofkristallamt.org/
>
> b...@hofkristallamt.org
>
> +1 925 209 7429
>
> +43 676 571 0536
>
> --
>
> Many plausible ideas vanish
>
> at the presence of thought
>
> --
>
>
>
> --
>
> To unsubscribe from the CCP4BB list, click the following link:
> https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1
>



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[ccp4bb] Quote source inquiry

2020-07-14 Thread Bernhard Rupp 
Hi Fellows,

 

afaicrimps (as far as I can recall in my progressing senility)  someone once
wrote/stated/cursed somewhere that "Macromolecular refinement is not a small
molecule structure determination method".  

 

Any citable source - George Sheldrick might be a suspect.

 

Thanks & best regards, BR

 

--

Bernhard Rupp

  http://www.hofkristallamt.org/

  b...@hofkristallamt.org

+1 925 209 7429

+43 676 571 0536

--

Many plausible ideas vanish 

at the presence of thought

--

 




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[ccp4bb] Postdoctoral position

2020-07-14 Thread David Mueller 
 An NIH funded position is open for a Post-doctoral/Research Associate.  There
are two exciting projects on the structure/function of the yeast ATP
synthase and studies on the structure and function of the Batten gene
product, Cln3.This provides an opportunity for training in any of these
areas such as allowing a crystallographer to learn methods in cryo-EM.  Since
the ATP synthase and the Cln3 gene product are membrane proteins, we
utilize overlapping methods in the studies. We also utilize yeast genetics
and expression systems to express and engineer proteins to aid in the
purification and structure determination.   While we do not have a cryo-EM
facility, we have active collaborations with other labs and get access to
national cryo-EM facilities.  We have computers dedicated and designed to
run the computational programs used in cryo-EM and x-ray crystallography.
We are located in North Chicago, home of Abbott Labs,  Abbvie and other
major pharma companies, and close to Northwestern University and  the city
of Chicago.

Apply for Postdoctoral Research Associate using the link below:
https://workforcenow.adp.com/mascsr/default/mdf/recruitment/recruitment.html?cid=395a4546-652f-4dd9-832f-b02e894ced6e=19000101_01=352890=en_US=CC4



-- 
David M. Mueller
IRP 265
Center for Genetic Diseases
The Chicago Medical School
Rosalind Franklin University of Medicine and Science
 Green Bay Road
North Chicago, IL 60064


*david.muel...@rosalindfranklin.edu
http://lmb-il.org/index.html
 *Office: 847-578-8606
FAX: 847-578-3240



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[ccp4bb] Research assistant job at the SGC, Goethe University Frankfurt

2020-07-14 Thread Apirat Chaikuad 
Posted on behalf on Dr. Susanne Mueller-Knapp:

 

We are currently having a research assistant job opening within our
structural/chemical biology team at the SGC, Frankfurt - Details below.

 

German version -
https://www.jobvector.de/jobs-stellenangebote/biologie-life-sciences/technis
che-assistenz/technischen-assistent-e-9a-136632.html

 

English version:

 

With over 48,000 students and around 5,000 employees, the Johann Wolfgang
Goethe University Frankfurt am Main is one of the largest universities in
Germany. Founded in 1914 by Frankfurt's citizens and since 2008 back in the
legal form of a foundation, the Goethe University possesses a high degree of
independence, modernity and professional diversity. As a comprehensive
university, the Goethe University Frankfurt offers more than 100 courses of
study on five campuses in a total of 16 subject areas and at the same time
possesses outstanding research strength.

 

The Department of Biochemistry, Chemistry and Pharmacy of the Goethe
University Frankfurt am Main offers immediately a positions of a

 

Research Assistant (m/f/d)

(E9 a TV-G-U)

 

limited until April 30th 2025. The salary grade is based on the job
characteristics of the collective agreement applicable to Goethe University
(TV-G-U). If the required qualifications are not available, you will be
payed according to the next lower level based on the above named collective
agreement.

 

We offer an exciting position embedded in an interdisciplinary research
environment. We are looking for people that are highly qualified and
motivated to join our international team.

 

The position is embedded in the Structural Genomics Consortium (SGC), a
not-for-profit, public-private partnership encompassing 8 pharmaceutical
companies that conducts pre-competitive research to facilitate the discovery
of new medicines.  Based at several additional international universities
(Oxford, Toronto, Chapel Hill, Campinas) the SGC's work contributes to new
hypotheses in understanding and treating human disease, and the subsequent
identification of new targets for drug discovery.  The SGC's primary
objectives are to produce and characterise the 3-dimensional structures of
soluble proteins and of integral membrane proteins, to generate selective
chemical probes for epigenetic proteins, kinases and other proteins, and to
release these into the public domain. As part of its mission the SGC
generates medically relevant reagents and knowledge related to human
proteins and proteins from human parasites, which it shares through over 250
collaborations with researchers worldwide.  

 

You will assist the research group, independently plan and evaluate
experiments, in particular in the area of  cell biology, as well as perform
administrative lab management tasks. You will have an education as BTA, MTA,
comparable education as technical assistant or a Bachelor in cell biology
and have already practical lab experience. You are highly motivated,
knowledgeable and have solid knowledge in molecular and cellular biology.
You have practical experience in relevant techniques (cloning, tranfection,
cellular assays), feel comfortable with relevant software, such as Graphpad
Prism, Office and similar. You have a detail-oriented and responsible
personality. Practical experience in high-throughput technologies and liquid
handling is a plus. You are familiar with lab management and are capable to
execute bench level experiments with the expectation that you will in time
be able to write protocols and contribute to the design of experimental
plans. You are expected to analyze data, record and report the results,
discussion and conclusions and suggest a plan moving forward. You are
passionate about your work and have a proactive attitude.  You are
comfortable to work with different personalities and cultures in an
international team. Fluency in English is a prerequisite. We offer a highly
stimulating and international research environment at the life science
campus Riedberg, and salary according to TV-G-U as well as 'Landesticket'. 

 

Goethe University is striving to increase the proportion of female
researchers and encourages in particular women to apply for the position.
People with disabilities will be given priority over other applicants with
the same qualifications. 

 

Interested candidates are encouraged to submit a cover letter stating career
interests, CV and contact addresses of at least two referees in a single PDF
no later than 22.07.2020 to the following e-mail address:
susanne.mueller-kn...@bmls.de.

 




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[ccp4bb] PhD position (or Research Associate) opportunity (with correct link to the job webpage)

2020-07-14 Thread Apirat Chaikuad 
Posted on behalf of Dr. Xinlai Cheng

 

In the Department of Biochemistry, Chemistry and Pharmacy - Institute of
Pharmaceutical Chemistry in the field of Medicinal Chemistry -  Dr. Xinlai
Cheng offers a position starting instantly of a PhD-Student/ Research
Associate (E13 TV-G-U, 50 % part-time).

 

limited up to 31.12.2022 (possible expansion to 31.12.2025). The salary
grade is based on the job characteristics of the collective agreement
applicable to Goethe University (TV-G-U).

 

Link to job webpage –
https://www.uni-frankfurt.de/48794939/FB14___Biochemie__Chemie_und_Pharmazie

 

 

Area of responsibility

 

The work will be done in a multi-disciplinary research environment
encompassing medicinal chemistry, stem cell and chemotherapy. The candidate
will work at the Buchmann Institute for Molecular Life
Sciences/Pharmaceutical Chemistry (Frankfurt am Main). The work will be
performed in close collaboration with other research groups in Frankfurt,
Heidelberg and Jena.

 

We are looking for a PhD-student (graduate student) who is interested to
work on a challenging project at the interface of chemistry, biochemistry
and (stem) cell biology. The aim of our project is to identify new bioactive
compounds and study the mechanism of action for regenerative medicine and
cancer therapy.

 

The candidate will be offered the opportunity to do self-directed research
and develop further scientific qualification.

 

Employment requirements

 

Applicants should have a master degree (or equal) in organic chemistry and
medicinal chemistry. The candidate should have experience in organic
synthesis, and in particular heterocyclic compounds synthesis. Knowledge on
the application of novel synthetic methodologies and PROTAC will be
advantageous. High level knowledge and good communication skills in English
and German are expected.

 

In order to increase the proportion of women in research, we particularly
encourage women to apply for this position. Disabled people will be
considered preferentially in the case of equal aptitude.

 

The planned research will be carried out in an international research
environment at the Life Science Campus Riedberg. Interested candidates are
encouraged to send applications until July, 22th 2020 to the following
e-mail address: Dr. rer.nat.habil.  Xinlai Cheng,
ch...@pharmchem.uni-frankfurt,de  ,
Goethe-Universität, Buchmann Institute for Molecular Life Sciences;
Pharmaceutical Chemistry; Max-von-Laue-Strasse 15. R. 3.652 ; 60438
Frankfurt am Main.

 

Best,

Dr. Xinlai Cheng




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