The Laboratory of Biomolecular Structure and Function (LBSF) at the University
of Oklahoma Health Sciences Center (OUHSC) seeks an experienced
crystallographer to run the daily operations of the LBSF. The position is at
the Staff Scientist level. The candidate will be responsible for working with
PIs to advance their structural biology projects. These efforts will include
routine technical operations, developing new protocols to overcome challenging
problems, and training the staff of user labs in protein purification,
crystallization, data collection, and structure determination. The ideal
candidate for this position will have a PhD and ten years of experience in
macromolecular crystallography, a strong work ethic, and the ability to
independently carry out each step of the standard crystallographic study
workflow: this a service position, not a training position. The candidate will
not be expected to write grant applications to support their position.
Pluses in a candidate's background include experience with instrument repair,
eukaryotic protein expression, membrane protein purification and LCP
crystallization, Cyro-EM, microED, SAXS, SANS, XAFS, NMR, or XFELS.
The LBSF is part of a suite of core labs supported in part by the OUHSC Vice
President of Research. The LBSF is also part of the Biomolecular Structure Core
(BSC) for the Oklahoma Center of Biomedical Research Excellence in Structural
Biology (OCSB), which is based on the main campus in Norman. The OCSB was
awarded five more years of NIH funding in May 2022. The BSC has contributed to
the awarding of 26 million dollars in grant funding and 36 publications in the
past ten years. The OCSB has been the focal point of Oklahoma's structural
biology community for nine years. The community includes 50 labs at three major
research institutions.
The BSC is a vital part of a new Center for Therapeutic Science. The center
coordinates and fosters the drug development pipeline with the BSC playing a
central role in structure-based drug design. The LBSF is working closely with
Dr. Matt Hart
(https://basicsciences.ouhsc.edu/bmb/Faculty/bio_details/hart-matthew-phd-1),
Director of the newly established Center for High Throughput Screening.
Most of the 12 major users of the LBSF have cancer-related projects. One
project led to the 2021 publication of crystal structures of RET Kinase bound
to two drug molecules recently approved by the FDA for the treatment of
non-small cell lung cancer (https://pubmed.ncbi.nlm.nih.gov/33161056/). Most of
the major users are members of the Stephenson Cancer Center, a National Cancer
Institute-designated cancer center.
The compensation level for this full-time position includes a generous benefits
package. The position is based in Oklahoma City -- an affordable place to raise
a family. To apply, please submit a cover letter, CV and contact information
(name and email) for three references to Blaine Mooers, Director of the
Laboratory of Biomolecular Structure and Function at OUHSC, at blaine-mooers at
ouhsc.edu. Also apply for Job # 223015 – Staff Scientist Structural Biology at
jobs.ou.edu. The position will remain open until filled. Application review
will begin immediately.
OUHSC is an equal opportunity employer and is committed to creating a diverse
and inclusive environment for all employees.
Best regards,
Blaine
Blaine Mooers, Ph.D.
Associate Professor
Department of Biochemistry and Molecular Biology, College of Medicine
Director of the Laboratory of Biomolecular Structure and Function
Academic Director, Biomolecular Structure Core, COBRE in Structural Biology
Full Member, Cancer Biology Program, Stephenson Cancer Center
University of Oklahoma Health Sciences Center
Mailing Address:
975 NE 10th Street, BRC 466
Oklahoma City, OK 73104-5419
Office: 405-271-8300 Lab: 405-271-8312
Websites:
Faculty page:
https://basicsciences.ouhsc.edu/bmb/Faculty/bio_details/mooers-blaine-hm-phd
BSC-OKC (LBSF):
https://research.ouhsc.edu/Core-Facilities/Laboratory-of-Biomolecular-Structure-and-Function
COBRE in Structural Biology: https://www.ou.edu/structuralbiology
To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1
This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list
hosted by www.jiscmail.ac.uk, terms & conditions are available at
https://www.jiscmail.ac.uk/policyandsecurity/
