Dear members of the community,
An exciting opportunity has emerged to join the Molecular Biophysics Group to
work on a BBSRC-supported collaborative project between the teams from
University of Leeds and Liverpool aimed at answering fundamental questions on
enzyme mechanism of quinol-dependent integral membrane nitric oxide reductases,
a member of respiratory heme-copper oxidase superfamily. The project builds on
our recent 2.2Å cryoEM structure of this enzyme and aims to address a number of
ambitious questions through well-informed point mutations and high resolution
cryoEM structures. In addition to the isolated enzyme, we also aim to obtain
the first structures of CuNiR-qNOR protein-protein complexes in catalytic
turnover.
We require a research assistant at Liverpool to support an experienced PDRA and
the team for this project. You will be responsible for producing wild-type and
mutant qNOR membrane bound proteins in sufficient quantities for functional and
cryoEM studies. You would also support in producing CuNIRs and their mutants
following the established protocols in our laboratories.
You should also be able to work in a team. You will have significant experience
in membrane protein purification. You will be provided with a range of training
opportunities including attending workshops and where appropriate conferences.
You will have a degree in a relevant subject area.
This post is available from 1 October 2023 until 30 September 2026.
The University has the right to close the vacancy early if it is deemed that
there have been enough applications received.
Job Ref: 063226
Closing Date: 28 August 2023
For full details and to apply online, please visit:
https://www.jobs.ac.uk/job/DBW146/research-assistant-structural-biology-of-membrane-proteins
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