Jacob, Many enzymes do this, not quite as dramatic as calmodulin, but especially hexokinase, and this is important because it was the origin of Koshland's "induced fit" idea. Glycogen phosphorylase, aspartate transcarbamylase, and phosphofructokinase also do radical things involving subunit rearrangements.
On Feb 28, 2014, at 2:49 AM, Andrew Leslie wrote: > Dear Jacob, > > Citrate synthase is another early (historically) case, and GAPDH (on binding > NAD). > > Andrew > > On 27 Feb 2014, at 19:43, "Keller, Jacob" <kell...@janelia.hhmi.org> wrote: > >> Dear Crystallographers, >> >> Does anyone know of good examples of large, reversible conformational >> changes occurring between ligand-free and -bound states? Could also be a >> non-relevant molecule binding, like sulfate or something inducing dubiously >> -relevant changes. I already know of the calmodulin and periplasmic binding >> protein families, but does anyone know of others out there? >> >> All the best, >> >> Jacob Keller >> >> ******************************************* >> Jacob Pearson Keller, PhD >> Looger Lab/HHMI Janelia Farms Research Campus >> 19700 Helix Dr, Ashburn, VA 20147 >> email: kell...@janelia.hhmi.org >> ******************************************* Elizabeth Goldsmith Patti Bell Brown (Chilton) Professor Department of Biophysics 214 645 6376 be...@chop.swmed.edu
