[Icon Description automatically generated with low confidence]Targeting the
replication machinery of Nipah virus
We are seeking three ambitious and highly motivated research scientists to join
a project funded by PAD – Pandemic Antiviral Discovery – which is a global
philanthropic initiative launched by the Bill & Melinda Gates Foundation and
Open Philanthropy in the US, and the Novo Nordisk Foundation (NNF) in Denmark.
The scientists will join the laboratories of Professor Jonathan Grimes at the
Division of Structural Biology, Professor Miles Carroll at the Pandemic
Sciences Institute and Professor Ervin Fodor at the Sir William Dunn School of
Pathology within the University of Oxford and will join a dynamic and
successful team of virologists, biochemists and structural biologists studying
the fundamental molecular mechanisms of virus replication. The project that
seeks to elucidate the molecular determinants of henipavirus replication,
pathogenesis and transmission for the purpose of developing therapeutic
discovery programs targeting virus and/or host-specific targets important for
virus replication. The project sits under the umbrella of the Pandemic Science
Institute ( https://www.psi.ox.ac.uk/what-we-do) which is an exciting,
high-profile new venture of the University of Oxford . The Institute will build
on Oxford’s world leading response to the Covid pandemic, bringing together
expertise from across the University and across the world to make the world
safer through science.
The three positions would suit enthusiastic and highly organised postdoctoral
scientists with an interest in viral replication and possessing the ability to
contribute conceptually to the overall research programme. The research program
will require a team with skills ranging from eukaryotic tissue culture
expression, virus handling and purification, protein expression and
purification through to protein crystallography and electron and fluorescence
microscopy. The three postdoctoral fellows will each be assigned primarily to
one of the three work packages: one will take the lead in driving the
structural analyses forward, the second on the development of the drug
screening and the third on the assay development and biochemistry of the
replicase complex.
Applicants must hold, or be close to completion of, a PhD in biochemistry,
molecular biology, biophysics or related sciences. Previous research published
in peer-reviewed scientific journals or as pre-print, good communication skills
and experience in advanced molecular biology techniques and experimentation are
essential.
If you are interested in the positions, please apply online through
https://www.jobs.ox.ac.uk/; Vacancy ID: 162453, 162062 and 162059.
You will be required to upload a CV and supporting statement as part of your
online application. The position is funded by the Bill & Melinda Gates
Foundation and Open Philanthropy in the US, and the Novo Nordisk Foundation
(NNF) and is for a three year fixed term (31 Dec 2025) with a possibility of
extension.
The closing date for applications is 12.00 midday on 13 January. Interviews
will be held as soon as possible thereafter.
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