[ccp4bb] The Antiviral Drug Discovery (AViDD) Open Science Forum virtual meeting is Wed 20 September 11.00A ET

[Lizbé Koekemoer]

*Antiviral Drug Discovery (AViDD) Open Science Forum*

*REMINDER*



The *next Antiviral Drug Discovery (AViDD) Open Science Forum virtual
meetin*

*g*

will
be *Wed 20 September 2023 at 8.00A PT / 11.00A ET / 4.00P UK (GMT+1) /
5.00P Geneva (GMT+2).*



Registration link




Moderator: *Frank von Delft*

 (Diamond Light Source

)

   - *Stephanie Wills, University of Oxford*
   

   : *Algorithms for progressing crystallographic fragment hits at XChem:
   Fragment merging using the Fragment Network*
   - *Serghei Glinca, CrystalsFirst*
   

   : *Magnet for the needle in haystacks: Unlocking chemical matter using
   “crystal structure first” fragment hits*



*Moderated discussion* [30 min, unrecorded]

For a schedule of upcoming events, recorded talks, more information, and
open antiviral discovery resources, see *http://openantivirals.org*

.

*The AViDD Open Science Forum is not an official NIAID activity. There is
no requirement for staff from AViDD Centers or NIH staff to participate in
this forum.*

Register for the virtual AViDD Open Science Forum event

[ccp4bb] 2 Postdoctoral positions availibe in Huber group at CMD Oxford

[Lizbé Koekemoer]

The Huber lab at the Centre for Medicines Discovery (CMD) at the Nuffield
Department of Medicine, University of Oxford, is looking for two highly
motivated and enthusiastic postdoctoral researchers to work with us to
investigate the fundamental role of novel RNA and ubiquitin binding
proteins in human disease.

You will investigate the structural and functional properties of individual
proteins as well as associated complexes involved in RNA and ubiquitin
metabolism. In addition, first-in-class chemical ligands will be designed
in collaboration with academic and pharma partners and characterised in
relevant biochemical assays. There are opportunities to gain experience in
fragment-based drug discovery and join a team of interdisciplinary
researchers.

Applicants are expected to have a strong and demonstrable track record in
protein biochemistry and X-ray crystallography; experience with cryoEM is
highly desirable. Both positions are offered full time on a fixed term
contract for 2 years in the first instance.



Additional details about the posts can be found online:

   1. Job Details (corehr.com)
   

   – closing date: 09-Oct-2023 12:00
   2. Job Details (corehr.com)
   

   – closing date: 09-Oct-2023 12:00


Interested candidates are welcome to contact Kilian Huber before applying
in case there are any additional questions.



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[ccp4bb] Two structural biology postdoc positions availible in the Huber group at the Centre of Medicines Discovery at Oxford University

[Lizbé Koekemoer]

The Huber lab at the Centre for Medicines Discovery (CMD) at the Nuffield
Department of Medicine, University of Oxford, is looking for two highly
motivated and enthusiastic postdoctoral researchers to work with us to
investigate the fundamental role of novel RNA and ubiquitin binding
proteins in human disease.

You will investigate the structural and functional properties of individual
proteins as well as associated complexes involved in RNA and ubiquitin
metabolism. In addition, first-in-class chemical ligands will be designed
in collaboration with academic and pharma partners and characterised in
relevant biochemical assays. There are opportunities to gain experience in
fragment-based drug discovery and join a team of interdisciplinary
researchers.

Applicants are expected to have a strong and demonstrable track record in
protein biochemistry and X-ray crystallography; experience with cryoEM is
highly desirable. Both positions are offered full time on a fixed term
contract for 2 years in the first instance.



Additional details about the posts can be found online:

   1. Job Details (corehr.com)
   

   – closing date: 11-Apr-2023 12:00
   2. Job Details (corehr.com)
   

   – closing date: 26-Apr-2023 12:00 GMT



Interested candidates are welcome to contact Kilian before applying in case
there are any additional questions.



Kilian Huber MRSC

Principal Investigator

Centre for Medicines Discovery



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[ccp4bb] Postdoctoral Scientist – Protein Biochemistry & Structural Biology - Huber group

[Lizbé Koekemoer]

Postdoctoral Scientist – Protein Biochemistry & Structural Biology
Target Discovery Institute, NDM Research Building, Old Road Campus,
Heading, Oxford, OX3 7BN

We are seeking to appoint a Postdoctoral scientist with experience in
protein purification, biophysical characterization of protein ligand
interactions, functional assay development as well as crystallization and
structure determination of proteins. You will join the CMD Chemical Biology
Group at the Target Discovery Institute, Nuffield Department of Medicine.

You will be responsible for unravelling the fundamental role of novel RNA
binding proteins involved in human disease. You will be developing
biochemical assays and studying the interaction of low molecular weight
modulators to protein interaction domains and understand the SAR (structure
activity relationship) of compound classes with the goal to develop a
highly selective first- in-class chemical probes. You will contribute to
the scientific output by publishing high quality manuscripts and by
representing the group on scientific meetings.

It is essential that you hold a PhD (or near completion) in protein
biochemistry and structural biology with an excellent academic track record
(at least one first author publication in an expert journal). Having an
extensive experience in cloning and recombinant protein purification using
bacterial, insect cell and mammalian host systems is essential, and you
will have a demonstrable experience in biochemical assay development using
various read-outs and biophysical ligand binding methods such as isothermal
titration calorimetry (ITC) and surface plasmon resonance (SPR).

Applications for this vacancy are to be made online and you will be
required to upload a supporting statement and CV as part of your online
application. Your supporting statement must explain how you meet each of
the selection criteria for the post using examples of your skills and
experience. You must not include copies (reprints) of your original
publications, all scientific outputs should be listed in standard journal
reference format.

This position is offered full time on a fixed term contract for 2 years in
the first instance and is funded by DBT/EUbOPEN. Previous applicants need
not apply.

https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_company=10_internal_external=E_display_in_irish=N_process_type=_applicant_no=_form_profile_detail=_display_apply_ind=Y_refresh_search=Y_recruitment_id=162995



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[ccp4bb] Antiviral Drug Discovery (AViDD) Open Science Forum TODAY

[Lizbé Koekemoer]

Good day all

Today we have the first of our monthly Open Science Forum talks featuring
scientists from NIH-funded Antiviral Drug Discovery (AViDD) Centers.

The program for today is 2x 30 min talks featuring:

   - *Frank von Delft, Diamond Light Source
   <https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html> (ASAP
   <http://asapdiscovery.org/>)*: *Moonshot lessons for open science:
   sustaining a collaboration platform for real-time data and idea sharing in
   targeting SARS-CoV-2 Main Protease*
   - *James Fraser, UCSF <https://pharmacy.ucsf.edu/james-fraser> (QBICRG
   <https://qbi.ucsf.edu/qcrgAViDD>)*: *The mechanisms of catalysis and
   ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and X-ray
   diffraction at room temperature*

 For more information and to register to attend please visity our website
https://asapdiscovery.org/forum/.

Regards
Lizbé Koekemoer



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[ccp4bb] Postdoctoral Scientist – Protein Biochemistry & Structural Biology - Huber group

[Lizbé Koekemoer]

Good day

The Huber group is seeking a highly motivated and enthusiastic Postdoctoral
Scientist to join us at the Centre for Medicines Discovery, at the Nuffield
Department of Medicine, to work on an exciting translational anticancer
research project located at the interface between academia and industry.

You will be responsible for establishing efficient expression and
purification systems of RNA modifying enzymes, and help unravel the
molecular mechanisms of substrate recognition and allosteric regulation by
co-crystallization of chemical fragments/ligands, substrates or complex
partners. You will develop biochemical assays and study the interaction of
lead compounds with these protein interaction domains and help understand
the SAR (structure activity relationship) of compound classes with the goal
to develop highly selective first- in-class chemical probes. You will
supervise junior and technical staff, while also coordinating this project
with other internal and external partners and provide progress reports. You
will be responsible for contributing to the scientific output by publishing
high quality manuscripts and by representing the group at international
scientific meetings.

This position is offered full time on a fixed term contract for 12 months,
and is funded by DBT.

More details can be found at
https://my.corehr.com/pls/uoxrecruit/erq_jobspec_version_4.display_form?p_refresh_search=Y_display_apply_ind=Y_process_type=_recruitment_id=158581_applicant_no=_company=10_display_in_irish=N_form_profile_detail=_internal_external=E



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[ccp4bb] Postdoctoral Scientist for Protein Crystallography SRF at the CMD Oxford

[Lizbé Koekemoer]

Good evening



We are seeking to appoint a Postdoctoral fellow for the Protein
Crystallography Small Research Facility (PX-SRF), under the supervision of
Professor Frank von Delft.  The successful candidate will support all
PX-SRF related activities, with the predominant focus on the projects in
the ASAP pipeline (
https://dndi.org/press-releases/2022/consortium-to-discover-antivirals-covid19-receives-nih-funding-develop-globally-accessible-treatments-pandemics/
). ASAP builds on the our previous experience with COVID Moonshot (
https://covid.postera.ai/covid).  Your role in the SRF is to drive
crystallography projects to obtain robust crystal systems ready for
fragment screening, and the development of biochemical and/or biophysical
assays for the characterization of protein ligand complexes of said
targets. In addition, we provide support to the wider CMD crystallography
community and are involved in training and hosting students and academic
visitors. As part of the von Delft group you will work closely with our
XChem team, based at Diamond Light source at Harwell campus, and you will
have the opportunity to get involved in fragment screening and XChem
pipeline methodology development (
https://www.diamond.ac.uk/Instruments/Mx/Fragment-Screening.html).



The details for the position can be found at this link: Job Details
(corehr.com)




Feel free to contact me with any queries at lizbe.koekem...@cmd.ox.ac.uk.

Regards

Lizbé



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