[ccp4bb] Drew University Residential School on Medicinal Chemistry and Biology in Drug Discovery (ResMed): A Comprehensive One-Week Course

[Strickland, Corey]

Public

All,
I was asked by the meeting organizers to let the CCP4 community 
know about the 2021 Residential School on Medicinal Chemistry and Biology in 
Drug Discovery.See below for information about the course and contact 
information.

Sincerely,
Corey

---

Drew University's 34th Annual ResMed Course: The Residential School on 
Medicinal Chemistry and Biology in Drug Discovery.  June 4-11, 2021, Virtual 
via Zoom

ResMed is a week-long graduate/professional-level course providing an 
accelerated program for medicinal chemists, biologists and other industrial and 
academic scientists who choose to broaden their knowledge of the drug discovery 
and development process. The course concentrates on the fundamentals of drug 
discovery spanning initial target validation through clinical development.  The 
course is taught by distinguished faculty from industry and academia and 
provides ample opportunity for discussion.Previous attendees with 
backgrounds in macromolecular crystallography have found the course of great 
value in their research projects.



Topics Covered:
Principles of Medicinal Chemistry
Cheminformatics
Antibody-Drug Conjugates
Preclinical Toxicology
Drug-like Properties
Molecular Modeling
Drug Metabolism
Clinical Development
Fragment-Based Drug Design
Enzyme Inhibition/Receptor  Binding
Designing Around Toxicophores
Case History Presentations
Hit-to-Lead Process
PROTACS
Bioisosteres

Principles of Lead Optimization
Kinase Inhibitors
Epigenetic Targets

Phenotypic Screening
Pharmacokinetics/ Protein Binding
Protein-Protein Interactions


General Information:  Program 
Information and Registration:
Drew University, ResMed   
www.drew.edu/resmed
36 Madison Ave, Hall of Sciences 319,
Madison, NJ 07940
(973) 408-4861 | res...@drew.edu

Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.



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[ccp4bb] Drew University’s 34th Annual ResMed Course: The Residential School on Medicinal Chemistry and Biology in Drug Discovery

[Strickland, Corey]

Public

All,

I was asked by the meeting organizers to let the CCP4 community 
know about the 2020 Residential School on Medicinal Chemistry and Biology in 
Drug Discovery.See below for information about the course and contact
information.

Sincerely,
Corey Strickland

---


Drew University’s 34th Annual ResMed Course: The Residential School on 
Medicinal Chemistry and Biology in Drug Discovery.  June 7-12, 2020, Hyatt 
Regency – Morristown, NJ

ResMed is a week-long graduate/professional-level course providing an 
accelerated program for medicinal chemists, biologists and other industrial and 
academic scientists who choose to broaden their knowledge of the drug discovery 
and development process. The course concentrates on the fundamentals of drug 
discovery spanning initial target validation through clinical development.  The 
course is taught by distinguished faculty from industry and academia and 
provides ample opportunity for discussion and networking.

Previous attendees with backgrounds in macromolecular crystallography have 
found the course of great value in their research projects.

Topics Covered:
Basic Principles of Medicinal Chemistry
Molecular Modeling
Principles of Lead Optimization
Drug Metabolism
Target Identification and Validation
Enzyme Inhibition
Cheminformatics
Preclinical Toxicology
Kinase Inhibitors
Phenotypic
Screening
Fragment-Based Drug Design
Improving Drug Candidates by Design
PROTACS
Epigenetic Targets
Drug-like Properties
Clinical Development
Bioisosteres
Hit-to-Lead Process in Drug Discovery
Protein Binding
Case History Presentations
Pharmacokinetics
Structure-Based Drug Design
Designing Around Toxicophores


The registration fees for professionals and students/post-docs include course 
materials, all meals, and hotel accommodations at the Hyatt Regency, Morristown 
NJ.  Reduced registration pricing is available through March 31, 2020.

General Information: 
Program Information and Registration:
Drew University, ResMed 
www.drew.edu/resmed
36 Madison Ave, Hall of Sciences 319,
Madison, NJ 07940
(973) 408-4861 | res...@drew.edu

Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.



To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB=1

[ccp4bb] 33rd Annual ResMed Course from June 9-14, 2019 at Drew University

[Strickland, Corey]

Public

All,

I was asked by the meeting organizers to let the CCP4 community 
know about the 2019 Residential School on Medicinal Chemistry and Biology in 
Drug Discovery.See below for information about the course and contact 
information.

Sincerely,
Corey

--

33rd Annual ResMed Course: The Residential School on Medicinal Chemistry and 
Biology in Drug Discovery.  June 9-14, 2019 - Drew University, Madison, NJ
ResMed is a week-long graduate/professional-level course providing an 
accelerated program for medicinal chemists, biologists and other industrial and 
academic scientists who choose to broaden their knowledge of the drug discovery 
and development process. The course concentrates on the fundamentals of drug 
discovery spanning initial target validation through clinical development.  The 
course is taught by distinguished faculty from industry and academia and 
provides ample opportunity for discussion and networking.

Previous attendees with backgrounds in macromolecular crystallography have 
found the course of great value in their research projects.

Topics Covered:
Basic Principles of Medicinal Chemistry

Molecular Modeling

Principles of Lead Optimization

Drug Metabolism

Target Identification and Validation

Enzyme Inhibition

Cheminformatics

Preclinical Toxicology

Kinase Inhibitors

G-Protein Coupled Receptors

Fragment-Based Drug Design

Improving Drug Candidates by Design

Drugs Affecting Ion Channels

Epigenetic Targets

Drug-like Properties

Clinical Development

Bioisosteres

Hit-to-Lead Process in Drug Discovery

Protein Binding

Case History Presentations

Pharmacokinetics

Structure-Based Drug Design

Designing Around Toxicophores




The registration fees for professionals and students/post-docs include course 
materials, all meals, and hotel accommodations (with shuttle bus service 
to/from campus).  Reduced registration pricing is available through March 31, 
2019.

General Information:Program 
Information and Registration:
Drew University, ResMed
www.drew.edu/resmed
36 Madison Ave, Hall of Sciences 319,
Madison, NJ 07940
(973) 408-4861 | res...@drew.edu



Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.



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[ccp4bb] 2019 Summer intern position at Merck & Co., Inc. Kenilworth, N.J

[Strickland, Corey]

Public



All,


We have the following 2019 summer intern position available.If 
you are interested please apply at  
https://merck.taleo.net/careersection/jobdetail.ftl?job=ADM009828





Sincerely,

Corey


Corey Strickland, Ph.D.
Director, Structural Sciences
Merck Research Labs
K15-ME111
2015 Galloping Hill Road
Kenilworth, NJ 07033








Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States 
and Canada, is a global health care leader with a diversified portfolio of 
prescription medicines, vaccines and animal health products. The difference 
between potential and achievement lies in the spark that fuels innovation and 
inventiveness; this is the space where Merck has codified its legacy for over a 
century. Merck's success is backed by ethical integrity, forward momentum, and 
an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, 
most research-intensive biopharmaceutical company. Today, we're doubling down 
on this goal. Merck Research Laboratories is a true scientific research 
facility of tomorrow, and will take Merck's leading discovery capabilities and 
world-class small molecule and biologics R expertise to create breakthrough 
science that radically changes the way we approach serious diseases.



The Structural Sciences group within Merck Research Laboratories located in 
Kenilworth, NJ, is seeking a summer intern. The intern will function as a 
fully-integrated member of a structural biology team, consisting of X-ray 
crystallographers, protein biochemists, and molecular biologists.


The job will involve the crystallization of monoclonal antibodies for drug 
delivery and purification.   The intern will apply various purification methods 
to generate proteins suitable for crystallization.Day-to-day research will 
focus on using techniques in protein biochemistry and biophysics to formulate 
and characterize these samples and setup crystallization experiments.   The 
intern will be responsible for accurate electronic notebook recording, safe 
laboratory practices, and presentation of data and their interpretation to a 
team of scientists. The intern will also attend departmental and team meetings 
to gain a wider perspective on the drug development process in the 
pharmaceutical industry.


We are seeking intern candidates with strong academic performance, 
communication skills, teamwork, and the ability to work in a cross-functional 
environment.


This is a full- time internship position. Housing subsidy is not available as 
part of this program and must be funded 100% by the student.

Qualifications

Education:
* Required: Candidates must be a currently enrolled in a Ph.D. program 
in chemistry, biology, biochemistry, structural biology or related discipline.

Required Experience and Skills:
* Candidates must be available to work full-time for up to (12) 
consecutive weeks beginning in May or June of 2019.
* Candidates must have completed at least (1) year of study toward 
Ph.D. degree by June of 2019.
 Preferred Experience and Skills:
* Candidates should have significant interest in protein 
crystallization and protein structure/function.
* Candidates should understand basic laboratory skills and safe lab 
practices.
* Candidates should have prior research experience such as: molecular 
biology, protein expression & purification, protein characterization using 
biochemical and biophysical techniques and/or protein crystallization

Your role at Merck is integral to helping the world meet new breakthroughs that 
affect generations to come, and we're counting on your skills and inventiveness 
to help make meaningful contributions to global medical advancement. At Merck, 
we're inventing for life.

To apply:
https://merck.taleo.net/careersection/jobdetail.ftl?job=ADM009828



Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.



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[ccp4bb] Residential School on Medicinal Chemistry and Biology in Drug Discovery (ResMed): A Comprehensive One-Week Course

[Strickland, Corey]

All,

I was asked by the meeting organizers to let the CCP4 community 
know about the 2018 Residential School on Medicinal Chemistry and Biology in 
Drug Discovery.See below for information about the course and contact 
information.

Sincerely,
Corey

-
Dear all,

The 32nd Annual ResMed: Residential School on Medicinal Chemistry and Biology 
in Drug Discovery, www.drew.edu/resmed will be held 
on June 10 - June 15, 2018 at Drew University, Madison NJ.  However, all 
resident attendees will be staying at The Madison 
Hotel, with further accommodations provided at 
the Morristown 
Inn 
as needed. There will be a shuttle to transport attendees to and from the 
campus. ResMed is co-sponsored by the ACS MEDI Division.

ResMed is a week-long graduate level course organized to provide an accelerated 
program for chemists, biologists and other industrial and academic scientists 
who wish to broaden their knowledge of drug discovery and development.  The 
School's aim is to concentrate on the fundamentals that are useful in drug 
discovery spanning initial target validation through clinical development. The 
program provides ample opportunity for discussions with distinguished faculty 
from industry and academia.

The purpose of the School is to provide a strong background in the principles 
of drug discovery and development to enhance collaborative drug discovery 
programs. Previous attendees with backgrounds in macromolecular crystallography 
have found the course of great value in their research projects.

The tuition rate for Hotel Residents will include hotel stay, ResMed tuition, 
course materials, and all meals. Information regarding ResMed can be accessed 
on our website: www.drew.edu/resmed including our 
program and application.

Please join us in our 32nd year. We look forward to seeing you.

Sincerely,
Co-organizers,
William J. Greenlee, Ph.D
Vincent P. Gullo, Ph.D.
Ronald J. Doll, Ph.D.
Marvin Bayne, Ph.D.

Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.

[ccp4bb] Job opening at Merck in Kenilworth, NJ

[Strickland, Corey]

All,

  We have an open position for a protein crystallographer with significant 
experience.  The position is located in our Kenilworth, NJ Structural Sciences 
group.  For the complete job description and to apply see the link below.

Sincerely,
Corey
_
Corey Strickland, Ph.D.
Director, Structural Sciences
Merck Research Labs
2015 Galloping Hill Road
Kenilworth, NJ 07033



https://taleo.msd.com/careersection/merck_external_career_section/jobdetail.ftl?job=CHE005843=en_id=mailto#.Wo81uGShbtc.mailto
Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.

[ccp4bb] Residential School on Medicinal Chemistry and Biology in Drug Discovery (ResMed): A Comprehensive One-Week Course

[Strickland, Corey]

All,

I was asked by the meeting organizers to let the CCP4 community 
know about the 2017 Residential School on Medicinal Chemistry and Biology in 
Drug Discovery.See below for information about the course and contact 
information..

Sincerely,
Corey

-

Dear all,

The 31st Annual ResMed: Residential School on Medicinal Chemistry and Biology 
in Drug Discovery, www.drew.edu/resmed will be held 
on June 12 - June 16, 2017 at Drew University, Madison NJ.  However, all 
resident attendees will be staying at The Madison 
Hotel and will be bussed to and from campus 
all week. ResMed is co-sponsored by the ACS MEDI Division.

ResMed is a week-long graduate level course organized to provide an accelerated 
program for chemists, biologists and other industrial and academic scientists 
who wish to broaden their knowledge of drug discovery and development.  The 
School's aim is to concentrate on the fundamentals that are useful in drug 
discovery spanning initial target validation through clinical development. The 
program provides ample opportunity for discussions with distinguished faculty 
from industry and academia.

The purpose of the School is to provide a strong background in the principles 
of drug discovery and development to enhance collaborative drug discovery 
programs. Previous attendees with backgrounds in macromolecular crystallography 
have found the course of great value in their research projects.

The tuition rate for Hotel Residents will include hotel stay, ResMed tuition, 
course materials, and all meals. Information regarding ResMed can be accessed 
on our website: www.drew.edu/resmed including our 
program and application.

Please join us in our 31st year. We look forward to seeing you.

Sincerely,
Co-organizers,
William J. Greenlee, Ph.D
Vincent P. Gullo, Ph.D.
Ronald J. Doll, Ph.D.


Notice:  This e-mail message, together with any attachments, contains
information of Merck & Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.

[ccp4bb] Meeting announcement - Residential School on Medicinal Chemistry and Biology in Drug Discovery

[Strickland, Corey]

All,

This is a bit off topic, but I think this could be of general 
interest to folks.See below for information about the Residential School 
on Medicinal Chemistry and Biology in Drug Discovery.

Sincerely,
Corey



Subject: Residential School on Medicinal Chemistry and Biology in Drug 
Discovery (ResMed): A Comprehensive One-Week Course
Dear all,
The 29th Annual ResMed: Residential School on Medicinal Chemistry and Biology 
in Drug Discovery will be held on June 7 - June 12, 2015 at Drew University in 
Madison, NJ and is co-sponsored by the ACS MEDI Division.
ResMed is a week-long graduate level course organized to provide an accelerated 
program for chemists, biologists and other industrial and academic scientists 
who wish to broaden their knowledge of drug discovery and development.  The 
School's aim is to concentrate on the fundamentals that are useful in drug 
discovery spanning initial target validation through clinical development. The 
program provides ample opportunity for discussions with distinguished faculty 
from industry and academia.
The purpose of the School is to provide a strong background in the principles 
of drug discovery and development to enhance collaborative drug discovery 
programs. Previous attendees with backgrounds in macromolecular crystallography 
have found the course of great value in their research projects.
Information regarding ResMed can be accessed on our website: 
www.drew.edu/resmedhttp://www.drew.edu/resmed including our program and 
application.
Please join us in our 29th year. We look forward to seeing you.
Sincerely,
Co-organizers,
William J. Greenlee, Ph.D
Vincent P. Gullo, Ph.D.
Ronald J. Doll, Ph.D.

Notice:  This e-mail message, together with any attachments, contains
information of Merck  Co., Inc. (2000 Galloping Hill Road, Kenilworth,
New Jersey, USA 07033), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.

[ccp4bb] Meeting Announcement: Residential School on Medicinal Chemistry and Biology in Drug Discovery

[Strickland, Corey]

All,

I was asked by the meeting organizers to let the CCP4 community know 
about the Residential School on Medicinal Chemistry and Biology in Drug 
Discovery.See below for information about the course and contact 
information.

Sincerely,
Corey


--



Residential School on Medicinal Chemistry and Biology in Drug Discovery 
(ResMed): A Comprehensive One-Week Course
(http://www.drew.edu/resmed/)

The 28th Annual ResMed: Residential School on Medicinal Chemistry and Biology 
in Drug Discovery will be held on June 8 - June 13, 2014 at Drew University in 
Madison, NJ and is co-sponsored by the ACS MEDI Division.
ResMed is a week-long graduate level course organized to provide an accelerated 
program for chemists, biologists and other industrial and academic scientists 
who wish to broaden their knowledge of drug discovery and development.  The 
School's aim is to concentrate on the fundamentals that are useful in drug 
discovery spanning initial target validation through clinical development. The 
program provides ample opportunity for discussions with distinguished faculty 
from industry and academia.
The purpose of the School is to provide a strong background in the principles 
of drug discovery and development to enhance collaborative drug discovery 
programs. Previous attendees with backgrounds in macromolecular crystallography 
have found the course of great value in their research projects. 
Information regarding ResMed can be accessed on our website: 
www.drew.edu/resmed including our program and application.
Please join us in our 28th year. We look forward to seeing you.


Co-organizers,
William J. Greenlee, Ph.D
Vincent P. Gullo, Ph.D. 
Ronald J. Doll, Ph.D.
Notice:  This e-mail message, together with any attachments, contains
information of Merck  Co., Inc. (One Merck Drive, Whitehouse Station,
New Jersey, USA 08889), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.

[ccp4bb] Summer Internship at Merck for Ph.D. students

[Strickland, Corey]

All,

We have a summer internship opening at Merck (see below for the details) 
for graduate students in the Global Structural Chemistry/X-ray 
crystallography/Biomolecular NMR group at either its Kenilworth, NJ or West 
Point, PA sites. Internships will begin in early June 2012, and will run for 
10-12 weeks.If you are interested please visit our career site at 
www.merck.com/careershttp://www.merck.com/careers to create a profile and 
submit your resume for requisition #CHE003379.

Sincerely,
Corey




--

Job Description
X-ray Crystallography/BioNMR Summer Internship 2012 - PhD:CHE003379

Description

Merck is a global health care leader with a diversified portfolio of 
prescription medicines, vaccines and consumer health products, as well as 
animal health products.   Today, we are building a new kind of healthcare 
company - one that is ready to help create a healthier future for all of us.

Our ability to excel depends on the integrity, knowledge, imagination, skill, 
diversity and teamwork of people like you.  To this end, we strive to create an 
environment of mutual respect, encouragement and teamwork. As part of our 
global team, you'll have the opportunity to collaborate with talented and 
dedicated colleagues while developing and expanding your career.

Merck Research Labs will be offering 2012 summer internships in the Global 
Structural Chemistry group (X-ray crystallography or Biomolecular NMR) at 
either its Kenilworth, NJ or West Point, PA sites.  Internships will begin in 
early June 2012, and will run for 9-11 weeks.

A suitable candidate has a science background with interest in the use of X-ray 
crystallography and/or Biomolecular NMR in drug discovery.  Not required, but a 
plus, would be experience in one or more of the areas of protein 
crystallization, X-ray theory, X-ray crystallography or Biomolecular NMR.  
Preference will be given to candidates having a strong math and/or physical 
science background with expertise in computers and computer programming.  
Candidates will gain firsthand experience in modern drug discovery, and will 
also make valuable contacts within the industry.

**Please note when applying for this position, the candidate MUST upload a 
cover letter or a personal statement letter and a copy of your unofficial 
transcript along with your resume.

Qualifications

Required:

 *   Currently pursuing a Ph.D. in Biomolecular NMR, X-ray crystallography, 
Computational Chemistry, Biophysics or a related field
 *   Applicants must be available for full-time employment for 9 - 11 weeks 
during the months of June - August 2012.


Preferred:

 *   Experience in one or more of the areas of protein crystallization, X-ray 
theory, X-ray crystallography or Biomolecular NMR
 *   Strong math and/or physical science background with expertise in computers 
and computer programming
 *   Science background with an interest in computers and drug discovery


Our employees are the key to our company's success.  We demonstrate our 
commitment to our employees by offering a competitive and valuable rewards 
program.  Merck's benefits are designed to support the wide range of goals, 
needs and lifestyles of our employees, and many of the people that matter the 
most in their lives.

To be considered for this position, please visit our career site at 
www.merck.com/careershttp://www.merck.com/careers to create a profile and 
submit your resume for requisition #CHE003379.  Merck is an equal opportunity 
employer, M/F/D/V - proudly embracing diversity in all of its manifestations.


Notice:  This e-mail message, together with any attachments, contains
information of Merck  Co., Inc. (One Merck Drive, Whitehouse Station,
New Jersey, USA 08889), and/or its affiliates Direct contact information
for affiliates is available at 
http://www.merck.com/contact/contacts.html) that may be confidential,
proprietary copyrighted and/or legally privileged. It is intended solely
for the use of the individual or entity named on this message. If you are
not the intended recipient, and have received this message in error,
please notify us immediately by reply e-mail and then delete it from 
your system.