[ccp4bb] Membrane Protein Expression, Purification and Characterization (mPEP3)@ EMBL Hamburg, 9-16 September 2024

[Margret Fischer]

Dear Colleagues,

I would like to draw your attention to the upcoming EMBO Course on 
“Membrane protein expression, purification, and characterization 3 ( 
mPEPC3) ”, which will take place from

9th until 16th September 2024 at the *EMBL Hamburg Unit*.

This EMBO Practical Course trains PhD students and early career postdocs 
with the latest developments in membrane protein production, 
characterization and structure determination methods. Modern protein 
expression techniques in various hosts will be presented and students 
will get acquainted with state-of-the-art approaches for studying 
structural and dynamic aspects of membrane proteins. An attitude to 
combine protein purification and characterization will be taught to 
impress the necessity on the students that proteins have to be 
conditioned with care to achieve structural information. The presence of 
a crystallization and cryo-EM facility as well as beamlines for SAXS and 
macromolecular crystallography at the venue will be employed to perform 
integrated structural biology experiments. The course has an emphasis on 
practicals in small groups, and we will ensure a close interaction 
between students and tutors.


The aim is to inspire the students to apply the newly acquired knowledge 
and to maintain interactions among themselves and the tutors afterwards.


/The application deadline is the 17th June 2024./
Further information can be found under the following link 
:*https://www.embl.org/about/info/course-and-conference-office/events/pep24-01/*


on behalf of the organisers,

Margret

--

Margret Fischer
European Molecular Biology Laboratory
Administrative Operations Manager
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] ARISE fellowship position, deadline: September 30, 2023

[Margret Fischer]

Dear all,

/Joining EMBL as technology developer and engineer /

*Integrated structure and metabolomics platform for microbial targets *

/ARISE fellowship position, deadline: September 30, 2023/**

/The Wilmanns Group at the EMBL Hamburg Unit aims to establish a 
multidisciplinary metabolomics/structure service platform for 
determination of turnover mechanisms of specific drugs or prodrugs by 
different microorganisms, in collaboration with Michael Zimmermann, 
Structural & Computational Biology Unit, EMBL Heidelberg. The platform 
will include establishment of a pipeline for high resolution structures 
of selected protein-drug complexes in microorganisms, and in-vitro 
analysis of the enzymatic processing of specific drugs by microorganisms. /


/In case of further interest please contact: /
/Matthias Wilmanns, email: matthias.wilma...@embl-hamburg.de /
/Michael Zimmermann, email: michael.zimmerm...@embl.de /
/
/
/Further information can be found under, including eligibility criteria: /
/https://www.embl.org/about/info/arise//

best wishes,
Margret

--

Margret Fischer
European Molecular Biology Laboratory
Administrative Operations Manager
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Group/Team leader position available@EMBL Hamburg

[Margret Fischer]

Dear colleagues,

I would like to inform you that the EMBL Hamburg Unit is currently 
advertising for a Group/Team leader position.


*Reference Number HH00216*: Group/Team leader - Integrated structural 
biology by Small Angle X-ray Scattering


/Closing date: 23rd October 2022
/

Further detailed information can be found under the following link:

https://s.embl.org/HH00216

Best wishes,

Margret

--

Margret Fischer
European Molecular Biology Laboratory
Administrative Operations Manager
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Senior Technical Officer Position available@EMBL Hamburg Unit

[Margret Fischer]

Dear colleagues,

we would like to inform you that the EMBL Hamburg Unit is currently 
advertising for a SAXS Beamline support scientist.

Deadline for application is the 28th May 2022

More detailed information can be found here:

https://www.embl.org/jobs/position/HH00213

best wishes,

Margret
--

Margret Fischer
European Molecular Biology Laboratory
Administrative Operations Manager
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Extended registration deadline: Approaches for in cellulo structural biology with X-rays from May 16th to 17th 2022 in Hamburg

[Margret Fischer]

*Extended registration deadline*

Dear all,

We are pleased to announce our 2-dayspractical workshop on */Approaches 
for in cellulo structural biology with X-rays /*from *May **16^th **to 
**17**^th **2022*in Hamburg, Germany.


The workshop will provide practical on-site training on the 
followingresearch topics and technical approaches:


 * Eukaryotic cell systems for applications in structural biology
 * Intracellular protein folding and crystallization
 * Detection and characterization of protein crystals
 * Fluorescence-activated cell sorting (FACS) techniques for
   applications in structural biology
 * Present and future opportunities in advanced X-ray crystallography
 * Sample delivery techniques for X-ray data experiments

The training will be carried out at the relevant infrastructures 
operated by the *European Molecular Biology Laboratory (EMBL)* on the 
DESY Hamburg-Bahrenfeld research campus and by the *European X-ray Free 
Electron Laser in Schenefeld*, near Hamburg.


Application for the workshop isopen here 
 and the *deadline for 
application **has been extended till April 10th 2022*. Successful 
candidates will be informed during the first week after the deadline.


The event will be heldas an in-person workshop.

Best regards,

on behalf of the organizing committee

Jan Blaha (EMBL Hamburg), Lars Redecke (University of Lübeck/DESY), 
Ekaterina Round (European XFEL), Sihyun Sung (EMBL Hamburg), Matthias 
Wilmanns (EMBL Hamburg)



*Vanya Opalchenska*
European Molecular Biology Laboratory
c/o DESY, Notkestrasse 85, bldg. 25A
22607 Hamburg, Germany
Tel.: +49-40-89902-224
Fax.: +49-40-89902-149




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[ccp4bb] Practical Workshop@EMBL and XFEL Hamburg: Approaches for in cellulo structural biology with X-rays from May 16th to 17th 2022

[Margret Fischer]

Dear all,

We are pleased to announce our 2-dayspractical workshop on */Approaches 
for in cellulo structural biology with X-rays /*from *May **16^th **to 
**17**^th **2022*in Hamburg, Germany.


The workshop will provide practical on-site training on the 
followingresearch topics and technical approaches:


 * Eukaryotic cell systems for applications in structural biology
 * Intracellular protein folding and crystallization
 * Detection and characterization of protein crystals
 * Fluorescence-activated cell sorting (FACS) techniques for
   applications in structural biology
 * Present and future opportunities in advanced X-ray crystallography
 * Sample delivery techniques for X-ray data experiments

The training will be carried out at the relevant infrastructures 
operated by the *European Molecular Biology Laboratory (EMBL)* on the 
DESY Hamburg-Bahrenfeld research campus and by the *European X-ray Free 
Electron Laser in Schenefeld*, near Hamburg.


Application for the workshop isopen here 
  and the *deadline for 
application is March **31^st **, 2022*. Successful candidates will be 
informed during the first week after the deadline.


The eventis currently planned as an in-person workshop.

Best regards,

on behalf of the organizing committee

Jan Blaha (EMBL Hamburg), Lars Redecke (University of Lübeck/DESY), 
Ekaterina Round (European XFEL), Sihyun Sung (EMBL Hamburg), Matthias 
Wilmanns (EMBL Hamburg)


*Vanya Opalchenska*

European Molecular Biology Laboratory
c/o DESY, Notkestrasse 85, bldg. 25A
22607 Hamburg, Germany
Tel.: +49-40-89902-224
Fax.: +49-40-89902-149



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[ccp4bb] eSPC, an Online Data Analysis Platform for Molecular Biophysics

[Margret Fischer]

Dear CCP4 community,

I would like to share our new software for data analysis of Molecular 
Biophysics experiments The platform enables users to upload and analyse 
raw data from several experimental techniques: steady-state fluorescence 
spectroscopy, microscale thermophoresis, and differential scanning 
fluorimetry experiments. It consists of three modules. FoldAffinity 
quantifies how an interaction between two molecules can further 
stabilise them. MoltenProt helps to estimate how durable a protein is in 
different conditions. ThermoAffinity identifies how strongly two 
molecules, e.g. a protein and a drug, bind to each other. It is freely 
accesible in a webserver: https://spc.embl-hamburg.de/


Find more at:
https://youtu.be/l7RIYVWp5hc


Best,

Maria

--
Maria Garcia Alai, PhD

Team Leader,
Head of Facility
Sample Preparation and Characterization
& High-throughput Crystallization

EMBL Hamburg
Address: EMBL (c/o DESY)
Notkestrasse 85, 22607
Hamburg, Germany
T +49 40 89902145 | F +49 40 89902149
www.embl-hamburg.de





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[ccp4bb] Group/Team leader position available@EMBL Hamburg

[Margret Fischer]

Dear colleagues,

I would like to inform you that the EMBL Hamburg Unit is currently 
advertising for a Group/Team leader position.


*Reference Number HH00201*: Group/Team leader - Integrated X-ray based 
structural biology and dynamics.


/Closing date: 8th August 2021/

Further detailed information can be found under the following link:

https://www.embl.org/jobs/position/HH00201 
<https://www.embl.org/jobs/position/HH00201>


Best wishes,

Margret

--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] MOSBRI: A new TNA for Molecular-Scale Biophysics Research Infrastructure

[Margret Fischer]

Dear all,

We would like to share with you the press release of the recently EU 
granted MOSBRI (Molecular-Scale Biophysics Research Infrastructure ). 
MOSBRI will connect leading molecular biophysics facilities across 11 
countries, including 13 academic centres of excellence and 2 industrial 
partners. Under the coordination of Institut Pasteur in France, the 
consortium will make their services available across the continent to 
scientists from both academia and industry. Each facility will 
contribute cutting-edge instrumentation and unique expertise. MOSBRI’s 
portfolio of services will span the entire field of molecular-scale 
biophysics.


Access to the large panel of cutting-edge biophysical technologies and 
unparalleled range of expertise of the consortium will be available at 
no cost to all European researchers from both academia and industry. 
MOSBRI will commence operations on the 1st of July of 2021.


For more information visit our website (https://www.mosbri.eu 
) or email cont...@mosbri.eu


Best,
Maria Garcia Alai

(on behalf of the MOSBRI consortium)

--

Maria Garcia Alai, PhD

Team Leader,
Head of Facility
Sample Preparation and Characterization
& High-throughput Crystallization

EMBL Hamburg Outstation
Address: EMBL (c/o DESY)
Notkestrasse 85, 22607
Hamburg, Germany
T +49 40 89902145 | F +49 40 89902149
www.embl-hamburg.de





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[ccp4bb] Virtual Workshop „Strategy for future EMBL research infrastructures in the Life Sciences in Hamburg“, 29.-30.3.2021

[Margret Fischer]

Dear Colleagues,

We are pleased to announce the virtual *Workshop **„**Strategy for 
future EMBL research infrastructures in the Life Sciences in 
Hamburg**“*taking place on Monday, 29th and Tuesday, 30th March 2021.
The aim of this workshop is to explore possible future directions for 
research and research services in structural biology. All interested 
scientists (user community, stake holders, funding organisations etc.)
are most cordially invited to participate. Details about the workshop 
can be found at https://indico.embl-hamburg.de/event/2/ 
<https://indico.embl-hamburg.de/event/2/>. The registration is open on a 
first come first serve basis with a limited number of places available.


best wishes,

Margret

on behalf of the workshop organisers: Thomas Schneider, Dmitri Svergun 
and Matthias Wilmanns


--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Beamline Scientist position available@EMBL Hamburg

[Margret Fischer]

Dear colleagues,

I would like to inform you that EMBL Hamburg Unit is currently 
advertising for a Beamline Scientist position in Small Angle Scattering.


Detailed information can be obtained under the following link*: 
*https://s.embl.org/HH00196 <https://s.embl.org/HH00196>


/Closing date  is 2nd February 2021/

Best wishes,

Margret
--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Postdoctoral position available at EMBL Hamburg

[Margret Fischer]

Dear all,
I would like to draw your attention to a postdoctoral Vacancy Notice in 
the research group of Dr. Matthias Wilmanns at the EMBL Hamburg Unit.


*Vacancy Notice: HH_00183*
Postdoctoral Fellowship: High-resolution structure and function of the 
multi-layered kidney slit diaphragm


Detailed information can be found under:
http://s.embl.org/HH00183


best wishes,
Margret

--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Two Group Leader positions available@EMBL Hamburg

[Margret Fischer]

Dear colleagues,

I would like to inform you that EMBL Hamburg is currently advertising 
for two Group Leader positions.


*Reference Number HH00190*: Group leader - New approaches in electron 
microscopy


/Closing date: 13th August 2020/

*Reference Number HH00191:* Group Leader - X-ray imaging of biological 
samples


/Closing date: 13th August 2020/

Further detailed information can be found under the following links:

http://s.embl.org/HH00190

http://s.embl.org/HH00191


Best wishes,

Margret

--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] EMBO global exchange lecture course in Santiago, Chile

[Margret Fischer]

Dear all,

we would like to draw your attention to the following EMBO global 
exchange lecture course :


EMBO global exchange lecture course *Structural and biophysical methods 
for biological macromolecules in solution* 14-20 October 2019 in 
Santiago, Chile http://meetings.embo.org/event/19-biophysical-methods 
Application deadline is next week! This Course covers the major 
structural and biophysical techniques employed for characterization of 
proteins and nucleic acids under close to native conditions. It includes 
lectures on: small angle X­-ray and neutron scattering, NMR, mass 
spectrometry, analytical ultracentrifugation, bioinformatic tools, 
cryo­EM and interdisciplinary approaches. The registration fee of 170 
euro will be requested from the academic participants covering the event 
materials, lodging and meals. A limited number of travel grants and 
child care grants are available. Best regards, Al Kikhney on behalf of 
the Organizers


--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Staff Scientist position available@EMBL Hamburg

[Margret Fischer]

Dear colleagues,

I would like to inform you that EMBL Hamburg is currently advertising for a 
Staff Scientist position in the research group of Matthias Wilmanns.
Deadline for application is 8th August 20

For informal enquiries, please contact Matthias Wilmanns directly at 
:matthias.wilma...@embl-hamburg.de

Further information regarding the position and how to apply can be found under 
the following link :http://s.embl.org/HH00172

best wishes,

Margret

--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Postdoctoral position available @EMBL Hamburg

[Margret Fischer]

Dear all,

we are currently looking for a highly motivated molecular biologist with 
protein biochemistry expertise to develop the use of single domain 
antibodies as a platform technology for structural and functional studies
at the EMBL Hamburg unit. The research portfolio of the Hamburg Unit is 
mainly focused on structures of membrane proteins and large protein 
complexes by diverse structural biology approaches including X-ray
crystallography and cryo-electron microscopy. The successful candidate 
will work in a collaborative environment together with structural and 
computational biologists. You will be affiliated with the research group 
of Christian Löw.
The Löw laboratory is specialized in structural biology of integral 
membrane proteins. The team uses innovative approaches to study the 
structure and dynamics of nutrient uptake systems.


Further information about the position can be obtained under the 
following link:http://s.embl.org/HH00169


best

Margret
--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Vacancies@EMBL Hamburg Unit

[Margret Fischer]

Dear all,

I would like to draw your attention to the following vacancy 
notices@EMBL Hamburg:


Staff Scientist - Preparation & Functional/Structural Characterization 
of Protein Complexes ( Deadline 31st January 2019)

http://s.embl.org/HH00162

Scientific Technical Officer - Single Particle Electron Microscopy at 
the EMBL Hamburg Unit ( Deadline 13th January 2019)

http://s.embl.org/HH00157


Postdoctoral Fellow - Structure Biology of Proteins Crystallized in 
Cells ( Deadline 13th January 2019)

http://s.embl.org/HH00156

Postdoctoral Fellow - Structure-based Molecular Mechanism of Protein 
Elasticity ( Deadline 13th January 2019)

http://s.embl.org/HH00158


Postdoctoral Fellow - Integrative Structural Studies of Peroxisomal 
Translocon Complexe ( Deadline 13th January 2019)

http://s.embl.org/HH00159


Postdoctoral Fellow - Structure-Based Drug Discovery by Private/Public 
Partnership ( Deadline 13th January 2019)

http://s.embl.org/HH00161

Any inquiries can be sent directly to : 
matthias.wilma...@embl-hamburg.de <mailto:matthias.wilma...@embl-hamburg.de>


Best wishes,
Margret
--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760



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[ccp4bb] Vacancy@the SPC Facility, EMBL Hamburg Unit

[Margret Fischer]

Dear colleagues,

I would like to inform you that EMBL Hamburg is currently advertising 
for a Scientific Officer for the Sample Preparation & Characterization 
(SPC).
The facility supports external researchers carrying out experiments on 3 
EMBL beamlines ( 2x MX and 1 SAXS). An extension of the SPC activities
is hosted in the new Centre for Structural Systems Biology (CSSB).The 
Scientific Officer – Biophysical Characterization will support users 
with the design,

execution and data analysis of biophysical experiments.

The facility currently covers a broad range of biophysical techniques, 
including calorimetry, mass spectroscopy, circular dichroism, 
fluorescence, microscale
thermophoresis, dynamic/static light scattering, infrared spectroscopy, 
surface plasmon resonance and biolayer Interferometry. The postholder 
will be responsible for
the maintenance and operation of biophysical instruments as well as for 
training users to operate the equipment independently. He/She will have an
opportunity to develop own relevant research activities within the 
framework of the group by Maria Garcia Alai related to the development 
of new methods at the SPC.


Deadline for application is the 1st July 2018

More detailed information can be found here: http://s.embl.org/HH00140

best wishes,

Margret
--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760

[ccp4bb] Vacancies@EMBL Hamburg Unit

[Margret Fischer]

Dear all,

I would like to draw your attention to the following vacancy 
notices@EMBL Hamburg:


*Scientific Technical Officer* - Platform for Integrated Structural 
Biology at EMBL/CSSB

http://s.embl.org/HH00138

*Postdoctoral Fellowship* - Integrated Structural Biology of Peroxisomal 
Translocon Complexes

http://s.embl.org/HH00134

*Postdoctoral Fellowship* - Integrated Structural Biology of Proteins 
involved in Cancer Metastasis

http://s.embl.org/HH00132

*Postdoctoral Fellowship* - Integrated Structural Biology of the Von 
Willebrand Factor

http://s.embl.org/HH00135

*Postdoctoral Fellowship * - Integrated Structural Biology of type VII 
secretion systems

http://s.embl.org/HH00136

*Postdoctoral Fellowship* - Mechanism of nitrogen incorporation 
in multifunctional protein complexes by time-resolved structural biology

http://s.embl.org/HH00133


The deadline for all applications is April 15*. *Any inquiries can be 
sent directly to : matthias.wilma...@embl-hamburg.de 
<mailto:matthias.wilma...@embl-hamburg.de>


best,
Margret
--

Margret Fischer
European Molecular Biology Laboratory
Senior Administrative Officer
Notkestrasse 85
22607 Hamburg
Germany
Tel: +49 40 89902110
Mob: +49 1754105760

[ccp4bb] iNext access to Enhanced support for SAXS and crystallization/serial,crystallography at EMBL Hamburg

[margret]

Dear all,

I would like to draw attention to the availability of enhanced support 
for sample preparation and characterization for SAXS and macromolecular 
crystallography at EMBL Hamburg. For SAXS, this includes biophysical 
characterization and optimization of samples, access to the P12 BioSAXS 
beamline and, if needed, assistance in data analysis. For MX,
the access includes high-throughput crystallization, automatic crystal 
harvesting and data collection on the EMBL beamlines P13 and P14.


The point of access for support is the Sample Preparation & 
Characterization (SPC) facility:


https://www.embl-hamburg.de/services/spc/index.html

Researchers within the European research area can apply for sponsored 
access through iNEXT, which includes sample shipment, travel from the 
home lab and all consumables:


http://www.inext-eu.org/access/

To obtain iNEXT access, a proposal should be submitted that describes the
biological background and translation research component of the project.
Interested scientists are encouraged first to contact the facility at 
s...@embl-hamburg.de.


Best regards,

Rob Meijers

[ccp4bb] Team Leader/Head of the Sample Preparation and Characterization Facility available@EMBL, Hamburg

[margret]

Dear colleagues,

I would like to inform you that EMBL Hamburg is currently advertising 
for a Team Leader/Head of the Sample Preparation and Characterization 
Facility.
The Sample Preparation & Characterization (SPC) facility supports 
external researchers carrying out experiments on 3 EMBL beamlines ( 2x 
MX and 1 SAXS) and hosts a variety
of instruments and techniques, including a high-throughput 
crystallization platform, various biophysical characterization 
approaches and several methods
to characterize protein/ligand interactions. An extension of the SPC 
activities is hosted in the new Centre for Structural Systems Biology 
(CSSB).
The EMBL SPC facility has a strong track record in the development and 
implementation of new technologies and approaches.


Deadline for application is the 3rd September 2017.

More detailed information can be found here:

http://s.embl.org/HH00121

best wishes,

Margret
--

[ccp4bb] BioStruct-X workshop on Industrial applications of synchrotron radiation in biological research!

[margret]

Ref: Register now for the BioStruct-X workshop on *Industrial 
applications of synchrotron radiation in biological research!*


**

*Early bird registration until March 31^st !*

In the frame of an EU funded project BioStruct-X 
http://biostruct-x.org/ coordinated by EMBL-Hamburg a Workshop is 
organized on *Industrial applications of synchrotron radiation in 
biological research*


*DESY Campus (CFEL building), Hamburg, Germany*

*15^th -- 17^th June 2015*

The workshop is aimed at:

-representatives of pharmaceutical companies and service providers for 
structural biology keen to meet new cooperation partners


-scientists engaged in biomedical research interested in learning more 
about opportunities and possibilities at synchrotron facilities


-developers and distributors of X-ray and analytical equipment.

The programme includes:

-presentations by the BioStruct-X partners and other service providers 
detailing the facilities and technologies open to access for industrial 
users,


-talks highlighting examples of research done using synchrotron radiation,

-a round table discussion on the future needs for synchrotron beamtime 
provision to the pharmaceutical industry,


-ample time for networking and discussions with a poster session, a 
delegate exhibition and tour of the local facilities at world's 
brightest synchrotron source, PETRA III.


Early bird registration (before March 31^st ) is 100 Euro -- afterwards 
200 Euro. The number of participants is limited to 130 on a first come, 
first served basis. Please follow the link below**for more details 
including on how to register and the workshop programme.


http://www.biostruct-x.eu/industry_workshop2015

We look forward to welcoming you to the DESY campus for stimulating and 
fruitful discussions!



On behalf of the organizers,

Margret

--

[ccp4bb] Group Leader position available@EMBL Hamburg

[margret]

Dear colleagues,

I would like to inform you that EMBL Hamburg is currently advertising 
for a group leader and laboratory head focusing on biological X-ray Free 
Electron Laser research.


We look forward to receiving your applications if you have demonstrated 
expertise and track record of challenging structural biology and/or 
imaging projects, making use of synchrotron radiation and preferably 
X-ray free electron laser radiation.


Deadline for application is the 28th February 2015.

More detailed information can be found here:

http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1ref=HH_00076back=%2Faboutus%2Fjobs%2Fsearchjobs%2Findex.php%3Floc%3D3%26list%3D1

Best seasonal greetings,


Margret

--

[ccp4bb] Software Developer Position@EMBL, Hamburg (Svergun Group)

[margret]

Dear All,

I would like to inform you that a software developer position is 
available at the EMBL Hamburg Unit in the research group of Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 12th January 2015
Further Detailed Information can be found under : 
http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jjid=53279aid=15470 
http://ig14.i-grasp.com/fe/tpl_embl01.asp?newms=jjid=53279aid=15470


*Software Developer, Reference HH_00075

* Applications are invited for a software maintainer for the SAXS 
software package ATSAS, a program suite for small-angle scattering data 
analysis from biological macromolecules. The ATSAS suite is a collection 
of 20+ applications, actively developed for more than 15 years by the 
SAXS group at EMBL-Hamburg. It is in use in more than a 1000 academic 
research institutes world-wide. The software maintainer for ATSAS shall 
further improve the internal processes and general user experience.


The successful candidate will work within the SAXS group in Hamburg  
that provides a stimulating work environment. This position also 
involves frequent contacts with international users of the software.



Regards
Margret Fischer
--

[ccp4bb] Industrial applications of synchrotron radiation in biology, June 15-17 2015

[margret]

Dear All,

The Hamburg Unit of the European Molecular Biology Laboratory is 
organizing a BioStruct-X Industrial Workshop,to take place
on the DESY Synchrotron Campus in Hamburg from June 15-17 2015. 
BioStruct-X (www.biostruct-x.eu http://www.biostruct-x.eu)is an 
integrated project
funded by the FP7 of the European Commission to support access for key 
methods in structural biology utilizing synchrotron radiation.


The workshop will start with two sessions presenting the facilities 
offered by BioStruct-X partners for protein
production/crystallization and the BioStruct-X synchrotron beamlines 
offering access to industrial users.


In the following sessions, industrial possibilities of macromolecular 
crystallography, small-angle X-ray scattering and medical imaging
will be presented.Here,four dedicated sessions are planned combining 
presentations from the BioStruct-X partners and from the industrial
users of the facilities. A special session will be devoted to the 
presentations by service providers to industry including SMEs and 
spin-off companies.


The workshop will finish with a round table discussion to define the 
future needs of the companies in the use of synchrotron radiation.


There will be 2-3 invited speakers and 2-3 slots for contributing talks 
per session.


The Workshop will take place on the premises of the DESY synchrotron 
facility in Hamburg which operates the storage ring Petra-3, currently
the most brilliant synchrotron radiation source worldwide. A tour to the 
biological beamlines in operation at Petra-3 will be included in
the program. There will be a poster session and ample opportunities for 
networking and advertizing.


The number of participants of the workshop will be limited to 130, and 
places will be given on a 'first come first served' basis.


The participation fee is 200 Euro. Further information about the 
workshop, including its program, organizers,


registration and abstract submission are available at

http://www.biostruct-x.eu/industry_workshop2015

We look forward to welcoming you to the workshop!

Should you have any questions, please get in touch with:


Dr. Melissa Graewert (m.graewert.embl-hamburg.de) or

Ivanka Araujo (i.araujo.embl-hamburg.de)

With best regards

Workshop Organizers

[ccp4bb] Structural and biophysical methods for biological macromolecules in solution, May 2015, Taipe

[margret]

*Structural and biophysical methods for biological macromolecules in 
solution *

EMBO Global Exchange Lecture Course, 4 - 10 May 2015, Taipei, Taiwan

http://events.embo.org/15-macromolecule/

The main objective of the Course is to teach the young PhD students and 
postdocs from all areas of biology the methods applicable to study 
biological macromolecules in solution. We aim at a comprehensive 
coverage of the field including the major structural and biophysical 
techniques employed for the characterization of high and low resolution 
structure and structural transitions, macromolecular complex formation, 
protein folding and stability, protein-protein and protein-ligand 
interactions and enzymatic mechanisms. The Course will include lectures 
on small-angle X-ray and neutron scattering (SAXS/SANS), nuclear 
magnetic resonance (NMR), static and dynamic light scattering (SLS/DLS), 
analytical ultracentrifugation (AUC), differential and isothermal 
calorimetry (DSC/ITC) and spectroscopic approaches. Bioinformatic tools 
to analyze protein-protein interactions will be considered, and the 
joint use of the solution characterization methods with the major 
non-solution structural techniques including macromolecular 
crystallography (MX) and electron microscopy (EM) will be covered. 
Special attention will be paid to interdisciplinary approaches, where 
the synergistic use of complementary techniques leads to a comprehensive 
description of macromolecular systems.


The course will be held at the Institute of Biological Chemistry, 
Academia Sinica, in Taipei.


A maximum of 50 participants will be selected to attend the course. The 
registration fee of 40 Euro (NT$ 1600) will be requested from the 
academic participants covering the event materials, lodging and local 
meals. Applicants from industry are expected to pay a 1000 Euro (NT$ 
4) fee.


The Course is oriented towards applicants active in structural biology,
mostly late Ph.D. students and early post-docs but more senior 
scientists, depending on circumstances, could also participate. Students 
working in Taiwan or Taiwanese students working abroad will be given 
preference but all applications are welcome.


Application deadline for the Course: February, 15th, 2015.

[ccp4bb] Postdoctoral Fellowship available@Meijers group, EMBL Hamburg Unit

[margret]

Dear all,

a three year postdoctoral position is available within the EIPOD (EMBL 
Interdisciplinary Postdocs) scheme in the group of Rob Meijers to study 
the role of the netrin receptor UNC5B in neuronal cell death. A more 
detailed description can be found here:


http://www.embl.de/training/postdocs/08-eipod/application/04_2014_project_ideas/meijers.pdf 



The research will take place at the EMBL Hamburg Outstation in Germany, 
in collaboration with the group of Francesca Peri at EMBL Heidelberg. 
Candidates with a background in protein crystallography and affinity 
with cell biology are encouraged to apply.


For more information on the EIPOD scheme, please visit:

http://www.embl.de/training/postdocs/08-eipod/index.html

A successful application will require a written motivation as to why 
this project is suitable, and candidates are therefore encouraged to 
contact Rob directly at:


http://www.embl-hamburg.de/research/unit/meijers/contact/index.html

The deadline for the application is 11th of September 2014.

Best regards,

Margret Fischer

[ccp4bb] SASBDB, www.sasbdb.org

[margret]

Dear Colleagues,

we are very pleased to  announce the launching of the Small Angle 
Scattering Biological Data Bank (SASBDB, www.sasbdb.org).
SASBDB was developed in accordance with the plans of the wwPDB SAS task 
force to establish a federated system of

interconnected databases for X-ray and neutron scattering (SAXS/SANS).

SASBDB is a curated repository that makes experimental SAS data and 
derived models of biological macromolecules
discoverable, citable and downloadable. Within SASBDB, it is possible to 
browse the scattering data and models,
search by various keywords including macromolecule name, buffer 
composition, experiment setup and author/affiliation
details. 3D representations of low resolution ab initio bead models and 
of the hybrid rigid body models

are available. All data sets and models can be freely downloaded.

Presently, SASBDB comprises of 96 experimental data sets and 151 models. 
Most of the entries contain published data from the studies
where SAS was used for the structural analysis of macromolecular 
solutions (proteins, nucleic acids and complexes). There
are also several benchmark data from a set of well-characterized 
commercially available proteins. The SAXS (and, for some
proteins, also wide-angle scattering, WAXS) data from these samples were 
collected using an on-line purification system to ensure
sample monodispersity. The benchmark set data and models can be used to 
test computational approaches, for tutorials etc.


Researchers are welcome to deposit the SAXS/SANS data and models into 
SASBDB (prior to or after the publication).
The submission requires a simple sign-in procedure followed by filling 
in anon-line deposition form and uploading the data/models.

ATSAS and ATSAS-online users may directly use their credentials to sign in.
The deposition is pre-moderated, i.e. the entries will be validated 
before making them public.


ATSAS Team, EMBL-Hamburg

[ccp4bb] Postdoctoral positions available at EMBL Hamburg

[margret]

Dear all,
I would like to draw your attention to two postdoctoral Vacancy Notices 
in the research group of Dr. Matthias Wilmanns at the EMBL Hamburg Unit:


*Vacancy Notice: HH_00065*
Postdoctoral Fellowship on Structure of Signaling segments in Muscle 
Filament Proteins


Project Outline: Many large muscle filament proteins have extended 
segments of signaling and kinase domains. In an interdisciplinary 
approach with proteomics and cell biology collaborators,
we wish to investigate the functions of these domains in vitro and an in 
vivo. We use combined structural biology approaches, with X-ray 
crystallography being the core method, to characterize

their mechanism of action.

http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jjid=52770aid=15470

*
**Vacancy Notice : HH_00067*
Postdoctoral Fellowship in Structural and functional relations of the 
Von Willebond Factor.


Project Outline: The Von Willebrand Factor comprises a large 
multi-domain protein assembly and has crucial roles in blood 
coagulation. Its function is regulated by shear forces. In collaboration
with clinicians, biologists and physicists we are interested in the 
overall structure of this protein and its domains by hybrid structural 
biology approaches.


http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jjid=52784aid=15470




best regards
Margret

[ccp4bb] EMBO practical course on Solution Scattering, Hamburg, 27 October - 3 November 2014

[margret]

*EMBO practical course on Solution Scattering from Biological 
Macromolecules *


The course will take place at EMBL Hamburg, Germany, on 27 October - 3 
November 2014


Organizers:
D. Svergun, R. Meijers, M. Petoukhov, A. Kikhney
(European Molecular Biology Laboratory, Hamburg Outstation)

The course aims at young biochemists/biophysicists and researchers 
active in related
structural methods (protein crystallography, NMR, electron microscopy) 
with little or no
experience in solution scattering. The course will cover basics of 
SAXS/SANS,
instrumentation, data collection, modelling techniques and complementary 
use with other

methods.

There will be no data collection from own samples at the EMBL SAXS 
beamline due to
the shutdown period of the Petra-3 ring but the students will get a 
hands-on experience
of a synchrotron experiment using pre-collected data from test proteins. 
Moreover, the
participants are encouraged to bring samples for biophysical 
characterization
(e.g. using light scattering, size exclusion chromatography and 
thermoflour experiments)
They may also bring the SAXS or SANS data collected on other facilities 
to be analysed

during the Course.

There is no registration fee and accommodation and subsistence are covered
for accepted applicants. Scientists from industry will be required to pay
a fee of Euro 1000. Limited travel grants are available to selected 
participants

coming from labs in countries in need of scientific strengthening.

The detailed course information and the online application form are
available at http://events.embo.org/14-sas/index.html

The deadline for applications is July 31st, 2014. The applications will
be considered by a Selection Committee and the results of the selection
procedure will be sent to applicants by email within about five weeks of
the closing date.

If you have any questions about the course, please post them to
http://www.saxier.org/forum/viewtopic.php?f=1t=2262

Best regards,
The Organizing Committee

[ccp4bb] Postdoctoral position available @ EMBL-Hamburg, SAXS

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in the research group of Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 15th December 2013.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


*Postdoctoral Positon, Reference HH_00053

* Applications are invited for a postdoctoral position in computational 
methods development for Biological SAXS in the BioSAXS group 
http://www.embl-hamburg.de/research/unit/svergun/index.html. The 
position is within BioStruct-X, an integrated project funded by Seventh 
Framework Programme (FP7) of the European Commission (www.biostruct-x.eu 
http://www.biostruct-x.eu). The successful candidate will participate 
in the design of an automated data analysis system to construct and 
validate 3D structural models from solution scattering data. The 
developments envisage hybrid applications of SAXS with other structural, 
biophysical and computational methods, including MX, NMR, electron 
microscopy and bioinformatic approaches..


The successful candidate will work on computational methods development 
for automated data analysis, storage and tracking, and on the 
cross-validation of SAXS models using the information from experimental 
techniques and also bioinformatic approaches. These developments are to 
be implemented at the high brilliance BioSAXS beamline of the EMBL at 
the Petra-III storage ring and also at the beamlines of the BioStruct-X 
partners.



Regards
Margret Fischer

[ccp4bb] Three Postdoctoral positions and one predoc position now available at EMBL Hamburg Unit

[margret]

We would like to draw your attention to the following three postdoctoral 
and 1 postdoctoral position open at the EMBL Hamburg Unit. Further 
details can be found below.

regards
Margret

The European Molecular Biology Laboratory (EMBL) is one of the highest ranked 
scientific research organisations in the world. The Headquarters Laboratory is 
located in Heidelberg (Germany), with additional sites in Grenoble (France), 
Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy). The main research 
focus of the EMBL Hamburg Unit is in challenging structural biology.  The 
following fellowships are available in the research group of Matthias Wilmanns:
 


*Postdoctoral Fellowship:*  Structural/Functional Studies on Proteins of the 
Peroxisomal Proliferation Machinery
Project outline: Proteins Pex11p and Pex25p are critically involved in the 
proliferation of peroxisomes. We would like to determine the structures of 
these proteins, possibly in complex with further peroxins, and complement 
structural work with in vivo functional characterization, in cooperation with 
partners of the EC ITN Network PERFUME (www.itn-perfume.eu).

*Postdoctoral Fellowship*: Structure of the Complete Pex5p-Pex14p Protein 
Translocon Complex  Cargo Complexes
Project Outline: To date, the overall structure of the peroxisomal translocon, 
a multi protein component complex across the peroxisomal membrane remains 
unknown. We are aiming to determine the structure of the minimal Pex5p-Pex14p 
protein translocon by a hybrid structural biology approach, including: X-ray 
crystallography, small angle X-ray scattering, biophysical methods, 
cross-linking, and electron microscopy (optional). In collaboration with 
partners of the peroxisomal network PerTrans we will raise structure-based 
hypotheses, to be investigated with a range of functional approaches
 
*Postdoctoral Fellowship*: Structure of the Human Peroxisomal PTS2 Receptor in the Presence of Co-receptors  Cargos  
Project Outline: Peroxisomal matrix proteins are recognized by two principle peroxisomal receptor, recognising protein targets either with a PTS1 or with a PTS2 motif. We are aiming to determine the structure of the human peroxisomal PTS2 receptor in the presence of co-receptors and cargos. In collaboration with partners of the peroxisomal network PerTrans we will raise structure-based hypotheses, to be investigated with a range of functional approaches.


*Informal inquiries should be sent to: wilma...@embl-hamburg.de
**For all three postdoc positions, please apply online throughwww.embl.org/jobs*
*Closing date for all fellowships: 15 September 2013
*
For further information:http://www.embl-hamburg.de/aboutus/jobs/
 



*Predoctoral fellowship*  (jointly with Henry Chapman, CFEL and University of 
Hamburg): In situ crystallization in peroxisomes  Project Outline: We would 
like to explore yeast peroxisomes as nucleation host for crystallization, 
leading to novel applications in structural biology. Expertise required: 
molecular biology, protein expression and purification, biochemistry. 
Additional expertise would be advantageous: crystallization, structural biology 
techniques, genetics. The project will provide an unique opportunity to become 
acquainted with established and emerging structural methods such the X-ray free 
electron laser, and X-ray imaging. This PhD thesis research project is part of 
the Center for Ultrafast Imaging at the University of Hamburg and will be 
co-directed by Matthias Wilmanns, EMBL, and Henry Chapman, DESY. For 
applications please go tohttp://www.cui.uni-hamburg.de/en/phd-positions/. 
Informal inquiries should be sent to:wilma...@embl-hamburg.de
 

[ccp4bb] EMBO Global Exchange Lecture Course in 2014- São Paulo, Brazil

[margret]

Dear all,
on behalf of Dr. Dmitri Svergun, I would like to draw your attention to 
the following EMBO Global funded course
that we will host together with Prof. Cristiano Luis Pinto de Oliveria 
in **São Paulo** in January 2014.


regards
Margret


*Structural and biophysical methods for biological macromolecules in solution
EMBO Global Exchange Lecture Course
19 -- 26 January 2014,  São Paulo, Brazil*

http://events.embo.org/14-macromolecule/

The main objective of the Course is to teach the young PhD students and 
postdocs from
all areas of biology the methods applicable to study biological macromolecules 
in
solution. We aim at a comprehensive coverage of the field including the major
structural and biophysical techniques employed for the characterization of high
and low resolution structure and structural transitions, macromolecular complex
formation, protein folding and stability, protein-protein and protein-ligand
interactions and enzymatic mechanisms. The Course will include lectures on 
small-angle
X-ray and neutron scattering (SAXS/SANS), nuclear magnetic resonance (NMR), 
static and
dynamic light scattering (SLS/DLS), analytical ultracentrifugation (AUC), 
differential
and isothermal calorimetry (DSC/ITC) and spectroscopic approaches.
Bioinformatic tools to analyze protein-protein interactions
will be considered, and the joint use of the solution characterization methods 
with the major
non-solution structural techniques including macromolecular crystallography 
(MX) and
electron microscopy (EM) will be covered. Special attention will be paid to 
interdisciplinary
approaches, where the synergistic use of complementary techniques leads to a
comprehensive description of macromolecular systems.

*The course will be held at the Adma Jafet Auditorium at Institute of Physics 
of the
University of Sao Paulo (IFUSP), Brazil.*

A maximum of*50 participants*  will be selected to attend the course.
A registration fee of 50 Euro will be requested from the academic participants
covering the event materials, lodging and local meals.
Applicants from industry are expected to pay a 1000 Euro fee.

The Course is oriented towards applicants active in Structural Biology,
mostly late Ph.D. students and early post-docs but more senior scientists,
depending on circumstances, could also participate.
Students working in Brazil or Brazilian students working abroad will be
given preference but all applications are welcome.

*Application deadline for the Course: October, 15th, 2013*

[ccp4bb] BSR-2013 News and A call for BSR-2016 bids

[margret]

Dear All,

with this mail we would like to draw your attention to the upcoming 11th 
Biology and Synchrotron Radiation Conference in

Hamburg ( Sunday 8th September until Wednesday 11th September 2013).

We were able to compile an exciting Conference Programme which is now 
available at

http://www.bsr2013.org/BSR13-01/programme/index.html.

Please note that the registration without abstract is open until August, 
15th, so there is still an

opportunity for participation!

We are also pleased to announce a bid for hosting the next Biology and 
Synchrotron Radiation Conference in 2016.

The decision about the venue for BSR-2016 will be taken during BSR-2013.
Further information regarding the bid can be found under the following 
link:


http://www.bsr2013.org/BSR13-01/info/Bid2016/index.html

We look forward to welcoming you all here in downtown Hamburg!

With best regards

Matthias Wilmanns, Dmitri Svergun, BSR-2013 Co-Chairs

[ccp4bb] Call for access to Synchrotron Beamline Facilities, autumn 2013 - EMBL, Hamburg, Germany

[margret]

Call for access to Synchrotron Beamline Facilities, autumn 2013 - EMBL, 
Hamburg, Germany


As you may already be aware, due to unforeseen circumstances related to 
the civil construction of the PETRA III extension, DESY has postponed 
the PETRA III shutdown and user operation will continue until the end of 
2013. Please note that the shutdown is now planned to last for most of 
2014.


In view of this, we announce a call for synchrotron beam time 
applications in biological small-angle X-ray scattering (SAXS) and 
macromolecular crystallography (MX) for the period September - December 
2013.


In biological SAXS, we offer access to an undulator beamline P12 
(responsible scientist Dmitri Svergun). Part of the beamtime will be 
available for soft condensed matter applications through a Collaborative 
Research Group model in partnership with the Helmholtz Zentrum Geesthacht.


In MX, access to the two undulator beamlines P13 and P14 is offered 
(responsible scientist Thomas Schneider).


Detailed description of the beamlines and links to the electronic beam 
proposal forms and are available at:


http://www.embl-hamburg.de/facilities/access_infrastructures/index.html

There will be no formal deadline for submission of proposals, and an 
external Project Evaluation Committee will assess the rolling proposals 
to the SAXS and MX beamlines. The evaluation time will be about 2 
months. The acceptance and the further scheduling will depend on the 
score and on the availability of the user slots.


Access to the EMBL Hamburg facilities will in part be supported by the 
European Commission, Research Infrastructure Action under the FP7 
project BioStruct-X (http://www.biostruct-x.eu/).


The users interested in assistance with crystallization, sample 
preparation and, in combination with their EMBL beamline visit, in 
sample characterization and optimization, can also apply for Biostruct-X 
support at:


http://www.biostruct-x.eu/content/embl-hamburg-protein-production-and-htx


For further information
tel. +49 40-89902-111
s...@embl-hamburg.de (small-angle X-ray scattering)
m...@embl-hamburg.de (macromolecular crystallography)
s...@embl-hamburg.de (sample preparation and characterization)

[ccp4bb] Postdoctoral position available @ EMBL-Hamburg, SAXS

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in the research group of Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 31st August 2013.
Detailed information can be found under : 
http://ig14.i-grasp.com//fe/tpl_embl01.asp?newms=jjid=51531aid=15470 
http://ig14.i-grasp.com/fe/tpl_embl01.asp?newms=jjid=51531aid=15470


*Postdoctoral Positon, Reference HH_00046*

Applications are invited for a postdoctoral position in computational 
methods development for biological SAXS in the BioSAXS group 
http://www.embl-hamburg.de/research/unit/svergun/index.html.The 
position is funded by *BioStruct-X*, an integrated project within the 
Seventh Framework Programme (FP7) of the European Commission 
(www.biostruct-x.eu http://www.biostruct-x.eu).


The fellow will participate in the design of an automated data analysis 
system to construct and validate structural models from solution 
scattering data. The developments envisage hybrid applications of SAXS 
with other structural, biophysical and computational methods, including 
MX, NMR, electron microscopy and bioinformatic approaches.


The candidate should have a PhD in physics, mathematics or biology and 
knowledge in computational and numerical methods. Experience in the use 
of programming languages (Fortran, C/C++ and/or Python) is essential. We 
specifically welcome applicants with background in computational 
crystallography, NMR, electron microscopy and/or bioinformatics. Good 
communication skills and the ability to collaborate with international 
teams are required.


on behalf of Dmitri Svergun

Margret Fischer

[ccp4bb] BSR-2013: Abstract submission deadline is extended until 20th June!

[margret]

*
11th International Conference: Biology and Synchrotron Radiation (BSR), 
8-11 September 2013, EMBL Hamburg, Germany *


The abstract submission deadline for BSR-2013 is *extended* until 
*Thursday 20th June*, 2013!


Biologists, physicists, chemists, from students to principal 
investigators, are invited to this tri-annual meeting with rich traditions.


Do not miss the unique opportunity to present your work, meet 
colleagues, friends and future collaboration partners from all over the 
world. Check out our preliminary programme to learn more.


BSR 2013 offers a tour of DESY's most impressive research 
infrastructures and includes a broad social programme to discover the 
vibrant city of Hamburg. Accompanying persons will enjoy special rates!


*Extended deadlines:

·Registration and abstract submission: 20 June 2013

·Registration without abstract: 15 August 2013 *

Take a look at the updates BSR webpage ( www.bsr2013.org 
http://www.bsr2013.org) for more information and to register.




CONTACT: diah.yulia...@embl.de mailto:diah.yulia...@embl.de,
or
margret.fisc...@embl-hamburg.de mailto:margret.fisc...@embl-hamburg.de


Alternatively, contact us on the event facebook page

[ccp4bb] Abstract submission deadline for BSR2013 is approaching!

[margret]

**

*11th International Conference: Biology and Synchrotron Radiation (BSR)
8-11 September 2013, EMBL Hamburg, Germany *

**

*Abstract submission deadline is approaching! 
http://www.embl-hamburg.de/training/events/2013/BSR13-01/registration/?utm_source=eventmailingutm_medium=E-Mailutm_content=bsr13-04utm_campaign=bsr***


*Join us in Hamburg, Germany for BSR 2013!*

Scientists at all possible career levels are invited to this meeting*. 
*Check out our preliminary programme 
http://www.embl-hamburg.de/training/events/2013/BSR13-01/programme/index.html?utm_source=eventmailingutm_medium=E-Mailutm_content=bsr13-04utm_campaign=bsr 
to learn more!


*Young researchers *are highly welcome to apply for a travel grant 
http://www.bsr2013.org/BSR13-01/info/index.html from the International 
Union of Crystallography when registering.


*Present your work! **
*Selected talks and poster sessions provide great opportunities for 
participants to present their work. Unique *networking opportunities* 
are also available to meet colleagues, friends and future collaboration 
partners from all over the world.


*Discover the city of Hamburg! **
*BSR 2013 includes asocial programme 
http://www.bsr2013.org/BSR13-01/attractions/index.html with boat trips 
and day and night excursions. Accompanying persons will enjoy special 
rates!


A tour of DESY's 
http://www.bsr2013.org/BSR13-01/desy/index.html?utm_source=eventmailingutm_medium=E-Mailutm_content=bsr13-04utm_campaign=bsr 
most impressive research infrastructures - including PETRA, FLASH and 
the future X-FEL -- is included in the registration fee.


*Dates at a glance:*

·*Registration and abstract submission: 1 June 2013*

·Registration without abstract: 1 August 2013

Take a look at the updated BSR webpage (www.bsr2013.org 
http://www.bsr2013.org) for more information and to register.


*CONTACT*
diah.yulia...@embl.de 
mailto:diah.yulia...@embl.de?subject=I%20would%20like%20to%20have%20information%20about%2011th%20International%20Conference%20on%20Biology%20and%20Synchrotron%20Radiation%20%28BSR%29 



Alternatively, contact us on the event facebook page 
http://de-de.facebook.com/events/332259356868854/?utm_source=eventmailingutm_medium=E-Mailutm_content=bsr13-04utm_campaign=bsr

[ccp4bb] IUCr Travel Grants Available - (11th International Conference on Biological Synchrotron Radiation (BSR), Hamburg, Germany, 8-11 Sept 2013)

[margret]

*IUCr Travel Grants Available!! *
*APPLY NOW!!*

*11th International Conference on Biological Synchrotron Radiation (BSR)*
*Hamburg, Germany*
*8th - 11th September 2013*

We are pleased to announce that we have a number of travel awards 
available for young scientists, kindly provided by the International 
Union of Crystallography (IUCr). Up to 450 Euros will be awarded to 
outstanding students for supporting travel costs. Applicants must be 
graduate students, post-graduate students or post doctoral fellows under 
the age of 30 (exceptionally 35). If you are eligible and wish to apply, 
please indicate this when you register for the conference. Successful 
applicants will be notified in the summer.


The 11th International conference on Biological Synchrotron Radiation 
(BSR) aims to bring together scientists involved in the methodical 
developments on synchrotron and laser sources with a broad community of 
biologists with an ambition to make the best use of the most advanced 
infrastructures in structural biology.


Topics include:

Biological small angle X-ray scattering

Macromolecular X-ray crystallography

Biological X-ray imaging and spectroscopy

Biological sample preparation

Free electron laser applications

Synchrotron instrumentation

Industrial applications

Structural biology hybrid methods

Ultimate storage rings


For more information and to register, please go to: www.bsr2013.org 
http://www.bsr2013.org



Looking forward to seeing you in Hamburg!

Margret Fischer on behalf of

Matthias Wilmanns,  Dmitri Svergun (EMBL Hamburg)

[ccp4bb] Postdoctoral position available @ EMBL-Hamburg, SAXS

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in the research group of Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 14th April 2013.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


*Postdoctoral Positon, Reference HH_00042

*Applications are invited for a postdoctoral position in the BioSAXS 
group http://www.embl-hamburg.de/research/unit/svergun/index.html. The 
position is within BioStruct-X, an integrated project funded by Seventh 
Framework Programme (FP7) of the European Commission (www.biostruct-x.eu 
http://www.biostruct-x.eu). In the framework of this project BioSAXS 
group develops novel hardware and software components for the high 
brilliance SAXS beamlines and for the interdisciplinary use of SAXS with 
other structural, biophysical and bioinformatic methods.


The successful candidate will work on computational methods development 
for automated data analysis, storage and tracking, and on the 
cross-validation of SAXS models using the information from experimental 
techniques and also bioinformatic approaches. These developments are to 
be implemented at the high brilliance BioSAXS beamline of the EMBL at 
the Petra-III storage ring and also at the beamlines of the BioStruct-X 
partners.



Regards
Margret Fischer

[ccp4bb] Group Leader Position@ EMBL/CSSB, Hamburg

[margret]

Dear colleagues,

I am writing to inform you that we are currently advertising for a Group 
Leader position at EMBL Hamburg and the future Center for Structural 
Systems Biology (CSSB) on the DESY campus in Hamburg, Germany.


EMBL is a partner of the future CSSB which aims to promote highly 
interdisciplinary and collaborative research projects between all partners.


The successful candidate will be expected to have experience and 
research interests in *Membrane Protein Crystallography*, and medically 
relevant research fields - preferably infection biology.


In particular, research interests should include:
-innovative use of synchrotron radiation in structural biology
-complementary 'hybrid' structural biology approaches
-interest in Free Electron Laser applications (optional)
-plans for complementary functional experiments

The deadline for applications is the *17th March 2013*.

For more information, please go to:

http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668 



Kind regards,

Margret
on behalf of Matthias Wilmanns

[ccp4bb] Call for Beamtime@EMBL Hamburg - Deadline 20th January 2013

[margret]

Dear Colleagues,

We announce a call for synchrotron beam time applications in biological
small-angle scattering (SAXS) and macromolecular crystallography (MX).
The beamtime will be available at the PETRA-III storage ring from
*March, 1st, 2013 to September, 15th, 2013* (please note the end date
change compared to the announcement in December 2012!).

In biological SAXS, we offer access to an undulator beamline P12:

  * 200 x 100 micron2 beam with 1013 ph/sec
  * Automated data collection with a robotic sample changer
  * Online FPLC and biophysical characterization of the sample
  * Remote and Fedex access
  * PILATUS 2M pixel detector covering the resolution from 2000 to 10 Å
  * http://www.embl-hamburg.de/facilities/saxs/index.html

Part of the beamtime on P12 will be available for soft condensed matter
applications through a Collaborative Research Group model in partnership
with the Helmholtz Zentrum Geesthacht.

For MX, access to two undulator beamlines - P13 and P14 - is offered.

  P13:
  * 50 x 50 micron2 beam with 1013 ph/sec
  * Apertures of 10/50/100 micron diameter
  * Energy 4.5 to 15 keV / Wavelength 0.82 - 2.7 A
  * MD2 diffractometer
  * PILATUS 6M (25 Hz) with 80 core compute server for XDS-processing
  * http://www.embl-hamburg.de/facilities/mx/P13

  P14:
  * 5 x 10 micron2 focused beam with up to 5 x 1012 ph/sec
  * Quick toggling (1 min) to unfocused flexible beam mode with
5-150 micron beam size.
  * Fixed energy 10 keV = 1.24 A
  * MD3 diffractometer with vertical spindle and kappa goniostat
  * PILATUS 6M (25 Hz) with 80 core compute server for XDS-processing
  * http://www.embl-hamburg.de/facilities/mx/P14

Electronic beam proposal forms and a detailed description of the
beamlines are available at

http://www.embl-hamburg.de/facilities/access_infrastructures/index.html

*The deadline for submission of proposals is January, 20th, 2013.
*An external Project Evaluation Committee will assess the proposals.

Access to the EMBL Hamburg facilities will in part be supported by the
European Commission, Research Infrastructure Action under the FP7
project BioStruct-X (http://www.biostruct-x.eu/).

Users that are interested in assistance with crystallization, sample
preparation and
characterization (SPC, also in combination with SAXS measurements) are
encouraged to
apply to the Biostruct-X support at

http://www.biostruct-x.eu/content/embl-hamburg-protein-production-and-htx

For further information
tel. +49 40-89902-111
s...@embl-hamburg.de   (SAXS)
m...@embl-hamburg.de   (MX)
s...@embl-hamburg.de   (SPC)

With best regards, EMBL Hamburg User Office

[ccp4bb] EMBO practical course on Computational Structural Biology - from data to structure to function, EMBL Hamburg, 15-19 April 2013

[margret]

Dear colleagues,

We are pleased to announce the upcoming EMBO practical course on
Computational Structural Biology - from data to structure to function

EMBL Hamburg, Germany
15th - 19th April 2013

The course covers computational aspects of protein structure
determination, validation and analysis, including background in X-ray
crystallography, Nuclear Magnetic Resonance Spectroscopy, Electron
Microscopy and Small-angle X-ray scattering and hands-on experience in
model building from X-ray diffraction data, comparing and integrating
different types of structural data, and the differences in
interpretation. Students will also learn to critically examine and
validate data from these techniques.

The course is aimed at PhD students and post-docs working on the
collection and analysis of protein structure data. The goal is to
provide them with insight into the protein structure determination
process, how to critically assess the quality of data from models, and
to provide expertise in the integration and visualisation of data from
different techniques, thus allowing the analysis of protein structure
data for functional relationships.

For more information and to apply, please go to:

http://events.embo.org/13-comp-structure/

Application deadline: 15th February 2013

We look forward to receiving your application!


Kind regards,
Margret

On behalf of the organising committee,
Gerard Kleywegt
Victor Lamzin
Christine Orengo
Gert Vriend
Rosemary Wilson

[ccp4bb] Call for access to Synchrotron Beamline Facilities 2013 - EMBL Hamburg,,Germany

[margret]

Dear Colleagues,

We announce a call for synchrotron beam time applications in biological
small-angle scattering (SAXS) and macromolecular crystallography (MX).
The beamtime will be available at the PETRA-III storage ring from
March, 1st, 2013 to June, 30th, 2013.

In biological SAXS, we offer access to an undulator beamline P12.
Part of the beamtime will be available for soft condensed matter
applications through a Collaborative Research Group model in partnership
with the Helmholtz Zentrum Geesthacht.

In MX, access to the two undulator beamlines P13 and P14 is offered.

Electronic beam proposal forms and a detailed description of the
beamlines are available at

http://www.embl-hamburg.de/facilities/access_infrastructures/index.html

The deadline for submission of proposals is January, 20th, 2013.
An external Project Evaluation Committee will assess the proposals.

Access to the EMBL Hamburg facilities will in part be supported by the
European Commission, Research Infrastructure Action under the FP7
project BioStruct-X (http://www.biostruct-x.eu/).

Users that are interested in assistance with crystallization, sample
preparation and
characterization (SPC, also in combination with SAXS measurements) are
encouraged to
apply to the Biostruct-X support at

http://www.biostruct-x.eu/content/embl-hamburg-protein-production-and-htx

For further information
tel. +49 40-89902-111
s...@embl-hamburg.de   (SAXS)
m...@embl-hamburg.de   (MX)
s...@embl-hamburg.de   (SPC)


regards

EMBL Hamburg User Office

[ccp4bb] Postdoctoral position available@SAXS, EMBL Hamburg

[margret]

Dear All,

I would like to inform you that a postdoctoral position is available at 
the EMBL Hamburg Unit in Small Angle Scattering in the research group of 
Dmitri Svergun.
I attach a brief description of the Vacancy Notice below. Deadline for 
application is 15th July 2012.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


Regards
Margret Fischer
---


*Postdoctoral Positon, Reference HH_00028*
Applications are invited for a postdoctoral position in the BioSAXS 
group (www.embl-hamburg.de/research/unit/svergun), which develops new 
approaches
to analyze the structure of biological macromolecules in solution using 
synchrotron radiation. The successful candidate will work on the 
interdisciplinary project
to understand the physical principles in the self-assembly of immature 
human immunodeficiency virus type 1 particles. The approach, supported 
by a grant
from the Human Frontiers Science Program, brings together teams from the 
USA, Germany and the Netherlands involving experts in retroviral 
molecular biology,
theoretical physics, materials chemistry and structural biology. The 
fellow is expected to design and perform time-resolved and anomalous 
synchrotron SAXS
experiments and to build structural models for the subunit assembly on 
specific templates, in close collaboration with the partners on the project.

[ccp4bb] 2 postdoctoral positions available@EMBL-Hamburg

[margret]

Dear All,

I would like to inform you that 2 postdoctoral positions are available 
at the EMBL Hamburg Unit in the research group of Matthias Wilmanns.
I attach brief descriptions of the Vacancy Notices below. Deadline for 
application is 15th June 2012.
Further Detailed Information can be found under : 
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


Regards
Margret Fischer
---

*Postdoctoral Positon, Reference HH_00025*
Applications are invited for research projects of the Wilmanns group in 
the EC-funded consortium SystemTB (www.systemtb.org), which aims to 
understand the pathology of /Mycobacterium tuberculosis/ during 
infection. While the core expertise of our group is in structural 
biology, we have established methods in mycobacterial genetics for the 
creation of full deletion mutants and specific point mutants using 
non-pathogenic model systems (M. smegmatis, BCG) (for examples, see: 
Noens et al. (2011) PMID: 2143903, Poulsen et al. (2010) Mol. Syst. 
Biol. PMID: 21439037). We have initialized several new collaborations 
using different --omics techniques, namely in interactomics (using 
high throughput mass spectrometry) (IBB Warsaw), metabolomics (ETH 
Zurich), proteomics (ETH Zurich), and lipidomics (CNRS Toulouse). The 
fellow is expected to carry out and to coordinate experiments in 
mycobacterial genetics in the context of ongoing and future projects. 
Most of them will be in cooperation with partners from the SystemTB 
consortium

*
Postdoctoral Positon, Reference HH_00026*
Applications are invited for research projects of the Wilmanns group 
(www.embl-hamburg.de/research/unit/wilmanns) in the new European 
consortium GoMoA with partners from Spain, France and Germany. The key 
aim of this network is to identify and to characterize protein targets 
from /Mycobacterium tuberculosis/ for lead compounds against 
tuberculosis that already have been validated by an industrial partner. 
The objective of our group is to contribute to the identification of 
protein targets, in collaboration with the group of Dr. John Overington 
from the EMBL-EBI Unit in Cambridge (UK), and on their biochemical and 
structural characterization. This novel research direction will 
complement our record in M. tuberculosis structural biology and 
functional characterization. The fellow is expected to carry out and to 
coordinate experiments in functional and subsequent structural 
characterization of protein targets from /M. tuberculos/

/
/

[ccp4bb] Beamline Scientist position in SAXS@EMBL Hamburg

[Margret Fischer]

Reminder!
Deadline for application: 4th March 2012

--

Vacancy Notice/Job Description

The European Molecular Biology Laboratory (EMBL) is one of the highest
ranked scientific research organisations in the world. The Headquarters
Laboratory is located in Heidelberg (Germany) and the outstations are in 
Grenoble (France),

Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).

Applications are invited for a Staff Scientist position at the Structural
Biology Unit of the EMBL in Hamburg, Germany. The position is within the
biological SAXS group, which runs a high brilliance user-oriented
synchrotron radiation P12 beamline on the storage ring PETRA 3. This
beamline is part of the integrated facilityofEMBL@PETRA3. The  successful
candidate will play a major role in scientific maintenance (development of
the beamline facilities, methods and technology), external user support and
collaborative projects at the beamline. The post is expected to be involved
in novel biological SAXS developments in collaboration with the other 
groups

of the EMBL@PETRA 3. There will be opportunities to link related
research activities with the operation of the beamline.

Qualifications and Experience

Applicants should have a PhD in a relevant field, proven record of
independent research, significant scientific accomplishments and expertise
in structure analysis of biological macromolecules using small-angle X-ray
scattering. Previous experience in hardware and/or software development for
synchrotron radiation beamlines is required.

Experience in work at a large-scale user-oriented facility, excellent
communication skills and ability to supervise and collaborate in
international team environment will be essential.

Please apply online throughwww.embl.org/jobs

[ccp4bb] EMBL Advanced Course: Hybrid Structural Biology Approaches

[Margret Fischer]

REGISTRATION NOW OPEN!!

EMBL Advanced Course: Hybrid Structural Biology Approaches

EMBL Hamburg, Germany
Monday 11 June - Saturday 16 June 2012

Organisers: V.Lamzin (EMBL Hamburg), R. Meijers (EMBL Hamburg), C.Sachse 
(EMBL Heidelberg), T.Schneider (EMBL Hamburg), D.Svergun (EMBL Hamburg), 
M.Wilmanns (EMBL Hamburg), R.Wilson (EMBL Hamburg)


The course will cover theoretical and experimental approaches to Small 
Angle X-ray Scattering (SAXS), Macromolecular Crystallography (MX) and 
Electron Microscopy (EM) offered at EMBL Hamburg and EMBL Heidelberg. 
Combined use of these structural techniques will be demonstrated and 
discussed.


The course is aimed at PhD students and postdocs who have at least a 
basic understanding of one (or more) of the techniques listed above, and 
are interested in learning more about hybrid structural biology approaches.


For more information and to register please go to:
http://www.embl-hamburg.de/training/events/2012/HYB12-01/index.html


--
Dr. Rosemary Wilson
Scientific Training and Outreach Officer

EMBL c/o DESY,
Building 25a
Notkestrasse 85,
22603 Hamburg,
Germany

[ccp4bb] Beamline Scientist position in SAXS@EMBL Hamburg

[Margret Fischer]

Dear all,

A beamline scientist position is available at the EMBL Hamburg Unit in Small 
Angle Scattering in the
research group of Dr. Dmitri Svergun.
I attach the Vacancy Notice below. Deadline for application is 4th March 2012.
Applications should be directed to:www.embl.org/jobs

regards
Margret
-
Vacancy Notice/Job Description

The European Molecular Biology Laboratory (EMBL) is one of the highest
ranked scientific research organisations in the world. The Headquarters
Laboratory is located in Heidelberg (Germany) and the outstations are in 
Grenoble (France),
Hamburg (Germany), Hinxton (UK) and Monterotondo (Italy).

Applications are invited for a Staff Scientist position at the Structural
Biology Unit of the EMBL in Hamburg, Germany. The position is within the
biological SAXS group, which runs a high brilliance user-oriented
synchrotron radiation P12 beamline on the storage ring PETRA 3. This
beamline is part of the integrated facilityofEMBL@PETRA3. The  successful
candidate will play a major role in scientific maintenance (development of
the beamline facilities, methods and technology), external user support and
collaborative projects at the beamline. The post is expected to be involved
in novel biological SAXS developments in collaboration with the other groups
of the EMBL@PETRA 3. There will be opportunities to link related
research activities with the operation of the beamline.

Qualifications and Experience

Applicants should have a PhD in a relevant field, proven record of
independent research, significant scientific accomplishments and expertise
in structure analysis of biological macromolecules using small-angle X-ray
scattering. Previous experience in hardware and/or software development for
synchrotron radiation beamlines is required.

Experience in work at a large-scale user-oriented facility, excellent
communication skills and ability to supervise and collaborate in
international team environment will be essential.

Please apply online throughwww.embl.org/jobs

[ccp4bb] Vacancy Notice for a Scientific Project Manager, EMBL Hamburg Unit

[Margret Fischer]

Dear all,
I would like to draw your attention to the following Vacancy Notice at 
the EMBL, Hamburg Unit:



Scientific Project Manager,  Reference number:  HH_00012

EMBL is seeking an EU Project Manager for the European research 
infrastructure project, Transnational access and enhancement of 
integrated Biological Structure determination at synchrotron X-ray 
facilities (BioStruct-X).


The project will be coordinated by EMBL Hamburg and will include a total 
of 19 partners from 10 European countries and Israel. It will provide 
supported access to state-of-the-art structural biology facilities in 
protein crystallography, small angle X-ray scattering, X-ray imaging and 
protein production. It will be complemented by a series of focused joint 
research and networking activities in relevant areas. The project is 
anticipated to start in the autumn 2011 and will run for four years.


The successful candidate will work closely with the scientific 
coordinator Matthias Wilmanns, the executive committee, all members of 
the consortium, and the funding organization (European Commission). The 
first tasks will be the establishment of appropriate management, data 
base, dissemination and networking structures of the project.


Further information can be obtained under the following link:
http://www.embl-hamburg.de/aboutus/jobs/searchjobs/index.php?newlang=1newms=srsearchregion=668


regards
Margret Fischer

[ccp4bb] Postdoctoral Position at EMBL, Hamburg

[Margret Fischer]

Dear all,
there is a postdoctoral position available at the EMBL Hamburg Unit:


The Meijers group at the EMBL Unit in Hamburg, Germany is looking for an 
outstanding post-doctoral scientist to work on structural aspects of the 
assembly and organization of the immunological synapse. We use a range 
of methodologies including cell biology, protein biochemistry, protein 
engineering, X-ray crystallography and bioinformatics to study the weak 
and specific interactions within the immunological synapse. The 
laboratory has access to state of the art protein production and 
characterization facilities. It will form an integral part of the new 
PETRA3 facility which is a new source of highly brilliant synchrotron 
radiation. Further information on the research performed in the lab can 
be found at:


http://www.embl-hamburg.de/research/unit/meijers/index.html

The ideal candidate should have a PhD in biochemistry or cell biology 
and extensive experience in protein expression and purification. 
Previous experience in protein structure determination would be an 
advantage. The candidate should have a willingness to develop new 
techniques in protein engineering that will open new avenues to study 
the dynamics and signaling of cell surface receptors.


An initial contract of 2 years will be offered to the successful 
candidate. This can be renewed depending on the circumstances at the 
time of review.


Closing date:  31st of January 2010

The European Molecular Biology Laboratory (EMBL) is an inclusive, equal 
opportunity employer offering attractive conditions and benefits 
appropriate to an international research organisation.


To apply please email a detailed CV, a statement of research interests 
and names (incl. e-mail address) of three potential referees by email 
quoting ref. no. W/09/PD/0103 in the subject line, to: 
applicat...@embl.de.


General enquiries may be sent to j...@embl.de

[ccp4bb] Team Leader Position at EMBL, Hamburg Unit

[Margret Fischer]

Dear All,
there is a job vacancy at the EMBL Hamburg for the following position:

*Team Leader Computational Infrastructures and Applications*

EMBL is building an integrated facility in structural biology at the
new PETRA-3 synchrotron ring at DESY, Hamburg, Germany. The optical
properties of PETRA-III will allow the operation of world-class
synchrotron radiation beamlines from 2010/11, providing an ideal
research environment for future challenges in structural biology.

We are looking for a Team Leader who will manage the local computer
group at EMBL-Hamburg and develop novel software and associated
infrastructure in cooperation with the researchers (e.g. for access to
remote experiments, particularly for the synchrotron beamlines at
PETRA-3 and the crystallisation facility). (S)he will administer and
further develop the local network, database administration and web
services using state-of-the-art technologies with a focus on a
user-friendly scientific computer environment. The post holder also
supervises and participates in installation, maintenance and development
of applications for the outstation's scientific user support, advanced
training and research projects. Candidates should hold a PhD in a
relevant field, have strong records in computational research and high
level scientific/technical accomplishments.

For a complete job description and to apply please visit: www.embl.org/jobs
http://www.embl.org/jobs

[ccp4bb] INSTRUCT workshop in Hamburg

[Margret Fischer]

INVITATION TO PARTICIPATE IN THE TANDEM INSTRUCT WORKSHOP

Intrinsically Unfolded Proteins in Structural Biology”
and
“Complementary Methods in Structural Biology”.

September 4th and 5th, 2008, Hamburg, Germany

The aim of this tandem workshop is to define research areas that should 
be covered by the participating workgroups, and to develop goals and 
strategies for future research in these areas.


The workshop will be organised in three sessions and will be open to 
interested participants. All conference attendees must register at the 
following website: 
http://www.embl-hamburg.de/workshops/2008/Registration2008/index.html


Deadline is August 15th, 2008. There is no workshop fee but places are 
limited and will be given on a first-come-first-served basis, therefore 
early registration is recommended.


The workshop is supported by the EU-funded project INSTRUCT (Integrated 
Structural Biology Infrastructure for Europe).


Further information on INSTRUCT can be found on the following website: 
http://www.instruct-fp7.eu/about.jsp


Scientific organising committee:

Joel Sussman, Weizmann Institute of Science, Rehovot, Israel
Dmitri Svergun, EMBL-Hamburg, Germany
Peter Timmins, ILL, Grenoble, France
Peter Tompa, Hungarian Academy of Sciences, Budapest, Hungary
Matthias Wilmanns, EMBL-Hamburg, Germany

Local contacts:
Dr. Rosemary Wilson, EMBL-Hamburg,
email: [EMAIL PROTECTED] (scientific officer)

Margret Fischer, EMBL-Hamburg,
email: [EMAIL PROTECTED] (administration)

[ccp4bb] EMBL Job Vacancy

[Margret Fischer]

Dear All,
there is a job vacancy at the EMBL Hamburg for the following position:

Scientific Training Officer (full-time or part-time)
Further Information can be obtained under the following link:

Scientific Training Officer (full-time or part-time)

Commencing date: As soon as possible

Job description: The primary duty is to implement the scientific 
training programme of the EMBL Hamburg Unit. This will involve:
- Coordination, teaching (where appropriate) and active participation in 
the organisation of the scientific programme for user-training courses, 
workshops, lectures, demonstrations and open days;
- Creating and updating tutorials, workbooks and eLearning materials in 
liaison with EMBL faculty. Making course materials available on the web, 
in close liaison with EMBL Hamburg services (IT, administration);
- Interacting closely with the EMBL International Centre for Advanced 
Training [EICAT] to optimise the use of EMBL¡¦s training facilities;

- Applying for training-related funding;
- Gathering and analysing training statistics, and promoting training 
events in liaison with other staff members.


The position will require extensive interactions with the Group and Team 
Leaders of EMBL-Hamburg Unit. There will be an option to complement 
these tasks by an active contribution to one of the ongoing research 
projects at the EMBL-Hamburg Unit.


This appointment will be available either as full-time or part-time.

Qualifications and experience: The ideal candidate will hold a PhD in 
natural sciences and will have minimally two years of postdoctoral 
experience in structural biology or a related research area. Previous 
know-how in research training and/or the development of training 
materials will be an important asset. Experience in designing and 
running scientific courses from introductory to advanced levels is 
necessary.


In addition to appropriate project management skills, the successful 
candidate will have excellent organisational and communication skills as 
well as the ability to contribute effectively to a team. Familiarity 
with Windows, MS Office, e-mail and Internet applications is essential. 
A working knowledge of other operating systems (e.g. UNIX/Linux) is 
highly desirable. HTML editing and designing, as well as knowledge of 
Adobe Creative Suite, QuarkXpress or other drawing and page-layout 
programmes are considered to be an advantage. Fluency in English is 
essential and familiarity with other European languages is desirable.


Contract: A contract of 3 years will be offered to the successful 
candidate. This can be renewed, depending on circumstances at the time 
of the review.


Closing date: 12 January 2008

Web page: http://www.embl-hamburg.de

EMBL is an inclusive, equal opportunity employer offering attractive 
conditions and benefits appropriate to an international research 
organisation.


Please note that EMBL does not return CVs or attached documents to 
applicants.


For further information about the post, please contact the Head of Unit, 
Dr. Matthias Wilmanns ([EMAIL PROTECTED]).


To apply, please send a CV (including names and addresses of references) 
and a covering letter, by e-mail, quoting ref. no. W/07/089 in the 
subject line, to: [EMAIL PROTECTED]


Personnel, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany.

Fax: +49 6221 387555   E-mail:  [EMAIL PROTECTED]

[ccp4bb] EMBL Job Vacancy

[Margret Fischer]

Dear All,
there is a job vacancy at the EMBL Hamburg for the following position:

Software Engineer: Database Management  Web Services
Further information can be obtained under the following link:

http://www-db.embl.de/jss/servlet/de.embl.bk.emblGroups.JobsPage/07091.html?EmblHH=x

Commencing date: As soon as possible after closing date

Job description: The Hamburg Unit of EMBL hosts an international 
laboratory with about 90 staff and fellows. The main activities are 
focused on research in structural biology, the provision of experimental 
facilities to the external research community, and advanced training for 
scientists. EMBL Hamburg coordinates and is involved in a number of 
national and international funded projects.


We are looking for a Software Engineer who will be responsible for:
• Maintenance and further development of an existing Oracle database.
• Development and provision of tools for data retrieval, statistics and 
reports.

• Responsible for the technical parts of local web services.
• Cooperation with local administration team, and integration into the 
IT team.
• Cooperation with relevant groups from the headquarters in Heidelberg 
(IT, Press Office, Grants Office, Administration) and external funding 
organisations.


Qualifications and experience: The ideal candidate has experience in web 
application development technologies on the basis of JAVA and Oracle. In 
addition, (s)he has knowledge in Unix/Linux, Python, Pearl, Apache, 
Apache Tomcat, SQL, shell scripting. Experience in an additional 
programme language (C, C++) would be beneficial. Very good knowledge of 
English is required and familiarity with other European languages is 
desirable. Excellent communication skills as well as a positive attitude 
towards cooperation in an interdisciplinary and international 
environment are necessary.


Contract: A contract of 3 years will be offered to the successful 
candidate. This can be renewed, depending on circumstances at the time 
of the review.


Closing date: 12 January 2008

Web page: http://www.embl-hamburg.de

EMBL is an inclusive, equal opportunity employer offering attractive 
conditions and benefits appropriate to an international research 
organisation.


Please note that EMBL does not return CVs or attached documents to 
applicants.


For further information about the post, please contact the Head of Unit, 
Dr. Matthias Wilmanns, [EMAIL PROTECTED], or the Head of the 
EMBL-Hamburg computer group, Dr. Frank Schmitz, [EMAIL PROTECTED]


To apply, please send an English CV (including a statement of previous 
accomplishments, names and addresses of referees) and covering letter, 
by e-mail, quoting ref. no. W/07/091 in the subject line, to: 
[EMAIL PROTECTED]


Personnel, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany.

Fax: +49 6221 387555   E-mail:  [EMAIL PROTECTED]

[ccp4bb] Fellowships available at EMBL Hamburg

[Margret Fischer]

PH.D. AND POSTDOCTORAL FELLOWSHIPS ON STRUCTURAL/FUNCTIONAL 
CHARACTERISATION OF PROTEIN INTERACTION NETWORKS IN YEAST


Two Ph.D. fellowships and one postdoctoral fellowship are available in 
the research group of Matthias Wilmanns at EMBL-Hamburg, Hamburg, Germany.


Src Homology 3 (SH3) domains are modular protein domains which are found 
in hundreds of multifunctional proteins from the human genome and tens 
of similar proteins in eukaryotic model organisms such as S. cerevisiae. 
Many of these proteins are involved in signalling and the organisation 
of the cytoskeleton, for instance. Although the structure and canonical 
binding site for proline-rich ligands has been well studied over more 
than a decade it remains largely unknown by what kind of mechanism many 
of known SH3-domains containing proteins are sorted to correct protein 
ligands within complex cellular networks, to allow their proper function 
in living systems.


The key aim of our future research will be to identify the molecular 
structural basis of cellular protein networks that are mediated by SH3 
domain containing proteins, using four yeast species (S. cerevisiae, S. 
pombe, A. gossypii, C. albicans) as models:


1) We are planning to determine structures of SH3 domain containing 
multifunctional proteins, to unravel their domain organisation, which 
may be important for correct folding and regulation of SH3 domain 
mediated protein/protein interactions.


2) We are aiming to determine structures of SH3 domain mediated 
protein/protein complexes, to provide insight into the molecular 
organisation of SH3 domains within complex protein networks in living 
systems.


3) We will exploit our structural data to explore the use of SH3 domains 
for drug discovery approaches, using both computational and experimental 
screening methods (a large depository of structures from S. cerevisiae 
is already available).


4) We will probe structure-based function by in vitro and in vivo 
approaches, by employing genetics, imaging techniques, and cell biology 
approaches.


Ph.D. fellowship candidates: Please apply at our central web pages: 
http://www.embl.org/training/phdprogramme/intro.html

The deadline for the next selection is: May 31, 2007.

Postdoctoral candidates: Please send your complete CV, including a list 
of publications, a statement of your present achievements and expertise, 
a list at least three addresses, from where letters of reference can be 
obtained. Previous experience in molecular biology, biochemistry, 
biophysical methods and X-ray crystallography is essential. The approach 
of our group is to integrate structural data into functional 
investigations. Please apply directly to Dr. Matthias Wilmanns, 
Notkestrasse 85, D-22603 Hamburg, Germany. Email: [EMAIL PROTECTED]


Further information about group activities: 
www.embl-hamburg.de/~wilmanns/home.html


The projects are supported by two EU networks, 3D Repertoire 
(www.3drepertoire.org/) and Penelope (penelope.crg.es), and EMBL.