Hi All, I would like to draw your attention to the following open position at CHARM Therapeutics located in Cambridge, UK.
Many thanks, Dr Andy Dore ****** For those that are interested, the application portal link is below: https://boards.eu.greenhouse.io/charmtx/jobs/4031659101 ****** JOB DESCRIPTION Tissue Culture Manager / Associate Principal Scientist at CHARM Therapeutics, Cambridge, UK. CHARM Therapeutics is a biotech company focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, and our ambition is to revolutionise drug discovery. CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK. We are seeking an experienced tissue culture scientist with a passion for scientific innovation. The successful candidate will join a multidisciplinary, highly collaborative discovery team to invent novel medicines and drive them towards the clinic. Role We are currently seeking an experienced tissue culture scientist to join the structural sciences group at CHARM Therapeutics at the level of Associate Principal Scientist, establishing, managing and maintaining our tissue culture laboratories utilising multiple expression systems to drive high throughput crystallographic structure determination across multiple SBDD campaigns. Requirements The successful candidate will be expected to meet the following criteria: Minimum of a strong honours degree plus a post graduate qualification up to, and including PhD level qualification in biochemistry / molecular biology, or a related discipline, is required. Additional previous experience in an industrial / biotech setting would be preferred. Extensive expertise and knowledge of recombinant protein expression systems; sterile cell culture techniques, protein biochemistry and downstream purification strategies and upstream molecular biology skills in terms of PCR, cloning, bacmid generation and sequencing. Experience in both transient transfection methods and baculovirus mediated expression protocols. Demonstrable track record of setting up, using and maintaining multiple and routine large scale expression systems - including bacterial, insect cell and mammalian adherent and suspension cell cultures. Experience in performing extensive quality control on protein expression runs., i.e. Western blot analysis, SDS-PAGE etc. Excellent organisational skills in terms of ordering tissue culture stocks and planning for expression run logistics. Excellent interpersonal skills with the ability to work as part of a team. Proven track record in presenting results (both written and verbal) to internal and external audiences. What we offer Private Medical Insurance, incl. dental & mental cover Competitive pension scheme Gym membership Weekly office lunch Office fruits & snacks Regular socials ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
