Dear Dhanasekaran,
There are many examples of molecular replacement failing even in cases
where the model and target structure share 100% sequence identity. These
examples illuminate several factors that MR search strategies are sensitive
to, including percent sequence identity and related paramet
Perhaps some "correct" solutions were thrown out due to packing
considerations.
There are a few methods to address that possibility. You could use a
search model with large loops trimmed, especially is a sequence
comparison shows they are probably not conserved. Or you could search
with a sui
Dear crystallographers,
I have solved a structure of a glucose
binding protein of CE4 family. When I try to solve the structure using the
same CE4 family enzyme as search model, it failed for many case. Finally, I
solved the with a same family enzyme used as searc
