Dear Brad,
the flexibility, that is how far a protein is stabilized with cold and heat
denaturation of a protein,
this inturn depends on
1.solvation enthalpy of nonpolar moieties(need more energy,so there needs to
be some randomness)
2.shift in temparature due to the enthalpy associated with transfer of
peptide group into water
3.its all depend truly on enthalpy convergence temperature and entropy
convergence temperature.
infact both quantities are characterised with large enthapy and entropy
compensation and; the temperature.
thanks
On Nov 13, 2007 6:07 PM, Ethan Merritt [EMAIL PROTECTED] wrote:
On Tuesday 13 November 2007 06:41, Brad Bennett wrote:
I would be interested then to know how the community feels about the
correlation of B-factors to protein flexibility. It is generally
accepted
that these are linked but are there any new papers that address this?
This is the basis of TLSMD analysis, and TLS refinement in general.
TLSM is described in
Painter Merritt (2006) Acta Cryst. D62, 439-450
http://skuld.bmsc.washington.edu/~tlsmdhttp://skuld.bmsc.washington.edu/%7Etlsmd
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Ethan A MerrittCourier Deliveries: 1959 NE Pacific
Dept of Biochemistry
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S.Jayashankar
Research Student
Institute for Biophysical Chemistry
Hannover Medical School
Germany
