Hi, I would like to advertise a position on behalf of Prof. Lois Weisman ((Michigan). Interested parties should contact her directly (lweisman.off...@gmail.com<mailto:lweisman.off...@gmail.com>). -Amir
Postdoctoral Fellow Position Integration of high resolution structures with biology Seeking a highly motivated postdoctoral fellow to initiate a new project in the general areas of phosphoinositide signaling or myosin V-based transport. We are a highly multidisciplinary, interactive laboratory, and use diverse techniques to address cutting edge questions on the roles and regulation of PtdIns(3,5)P2 and PtdIns(5)P in yeast and mice. Specifically we are determining how the lipid kinase, Fab1/PIKfyve is regulated, identifying the upstream signaling pathways, and downstream targets. In addition, we seek to determine the precise roles of Fab1/PIKfyve in the nervous system, and how minor perturbations in this pathway lead to profound neurodegeneration. Another critical area of research is determining how myosin V attaches to cargoes. We recently found that the cargo-binding domain of myosin V interacts directly with a subunit of the exocyst tethering complex [Jin et al. (2011) Dev. Cell. 21(6):1156-70.]. This paper illustrates the power of combining yeast genetics with high-resolution structures. Many additional projects in our lab are poised to utilize this type of approach. For an overview of recent projects, see our website: http://www.lsi.umich.edu/facultyresearch/labs/weisman Qualifications: A Ph.D. in the life sciences. Experience in molecular, biochemical and/or cell biological techniques. A level of publications appropriate for the current level of training. The applicant should be dedicated to research in the life sciences and have a strong desire to make major contributions. Please submit cover letter, CV with name of three references, and a brief paragraph indicating a project of interest to lweisman.off...@gmail.com<mailto:lweisman.off...@gmail.com> The University of Michigan is an equal opportunity/affirmative action employer.
