Postdoctoral Research Associate
University of Liverpool - Department of Cardiovascular and Metabolic Medicine
Location:       Liverpool
Salary: £34,810 to £40,322 p.a.
Hours:  Full Time
Contract Type:  Fixed-Term/Contract
Placed On:      25th August 2021
Closes: 21st September 2021
Job Ref:        033448
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We are looking for an enthusiastic Post-doctoral Research Associate to join the 
team of Dr Nordine Helassa on a 3-year British Heart Foundation funded project. 
Hypertrophic cardiomyopathy (HCM) is an autosomal dominant disease that can 
cause life-threatening cardiac arrythmias. It is the most common cause of 
sudden death in the young and is characterised by ventricular hypertrophy and 
contractile dysfunction. HCM has been associated with mutations in genes mostly 
encoding sarcomeric proteins such as myosin, tropomyosin and troponins. 
However, the detailed molecular mechanism leading to the clinical phenotype 
remains unclear. The project aims to determine the role of disease-associated 
troponin I mutations in cardiac dysfunction using a multidisciplinary approach 
combining protein biophysics, structural biology and muscle physiology.

You will have (or have already submitted) a PhD in structural biology, 
biochemistry, biophysics, biological sciences or a closely allied discipline. 
Laboratory experience with recombinant protein expression/purification 
techniques and structural biology (X-ray and/or NMR) would be advantageous. The 
post is available until 30 November 2024.

For full details and to apply online, please visit: 
https://recruit.liverpool.ac.uk<https://recruit.liverpool.ac.uk/>

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