We have a postdoctoral position open in the Fragment-Based Drug Discovery (FBDD) group in Drug and Biomaterial R&D at Genzyme Corporation in Waltham, MA. We are seeking a highly motivated recent PhD graduate in Structural Biology for a two-year position with a possible one-year extension. This position offers opportunities to work on structural biology of protein targets of therapeutic importance, involving activities from construct design to structural determination of target protein in complex with substrates or inhibitors. The successful candidate will have access to our cutting edge FBDD technology, including state of the art crystallization, X-ray diffraction system and biophysical analysis platforms. This postdoctoral associate will also have the opportunity to contribute to active discovery programs and gain experience across key aspects of biotech drug discovery as a member of a successful multidisciplinary team.
Basic Qualifications: PhD in structural biology or related disciplines (biochemistry, biophysics) with track record of solving X-ray crystal structures of proteins and protein complexes. Experience with construct design, protein purification, protein crystallization, data collection, structure determination and interpretation are essential. Preferred Qualifications: Strong background in biochemistry with in-depth understanding of ligand-protein interactions and familiarity with techniques such as ITC, surface plasmon resonance etc. to characterize proteins in support of structural biology is highly desired. Genzyme Corporation, ranked as one of the foremost biotechnology companies in the world, is committed to providing an exceptional environment in which individuals can excel, and achieve their professional and personal goals. Genzyme Corporation has been selected by FORTUNE magazine as one of the "100 Best Companies to Work For in 2006 in the United States". By applying for a position with Genzyme, you are taking the first step toward becoming a part of our dynamic and talented team, and hopefully sharing in our continued success. If you are interested, please apply online at www.genzyme.com/careers (requisition ID 21308).
