On top of what Eleanor mentioned, looking for about 160 S atoms with
anomalous signal to 3.9A will be VERY hard. If you manage actually
find those sites (or a good subset of them), the next density
modification step can also be very hard: jumping over that 3.5-4A
hurdle to get interpretable density
Well - I would start with a self rotation analysis. That non-cryst twofold
and three folds would suggest something with 3-2 symmetry. I vaguely
remember an insulin structure with the hexamer 3-fold in similar
orientation..
And this paterson peak "one major off origin peak at 0.5 0.5 0.173" might