Dear All: I have a quick question: how common it is that electrostatic interactions are involved in intra-molecular interactions, particularly in intrinsically disordered proteins? Is this interaction specific and any example? Thanks, Dee Xiaodi Yu, Ph.D. Boston Children's Hospital
Dee, Intramolecular electrostatic interactions are common in protein structures, for example between i and i+4 pairs on the same face of a helix. Robert Baldwin (Stanford) and others did a lot of work on the contribution of intramolecular salt bridges to helix stabilization in model helices.
On 11/03/2012 12:06 PM, Xiaodi Yu wrote: how common it is that electrostatic interactions are involved in intra-molecular interactions, particularly in intrinsically disordered proteins? It's impossible to answer your question unless you define what you mean by degree of commonality. If you
For some starting points, google electrostatic interactions in intrinsically disordered proteins. Of course they occur in IDPs; they even have proportionally more charged residues than folded proteins. Petri On Nov 3, 2012, at 5:06 PM, Xiaodi Yu wrote: Dear All: I have a quick question:
On 02/11/12 00:59, Michaela Renner-schneck wrote: Hi, I just upgraded from coot 0.6.2 to 0.7 - the stand alone package for running on mac os x 10.8. While 0.6.2 is running perfectly well with the XQartz environment 0.7. totally messes up the graphical display of the model... Relevant?