[ccp4bb] PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles

[Cornelius Gati]

PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles


The position is available starting immediately in the Department of Biological 
Sciences at the University of Southern California and is initially limited to 2 
years, with possible extension.


Our research focuses on the structural biology of G protein-coupled receptors 
involved in neurobiology and immunology, using single particle cryoEM, 
complemented with biophysical assays.


USC has a suite of research facilities and has recently commissioned a 
brand-new cryoEM facility:

• CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, 
Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS 
and screening
• Core facility for insect- and mammalian cell expression
• High performance computing for data processing/analysis


Qualified candidates must have a Ph.D. degree with a solid background in 
structural biology and biophysics/biochemistry. Previous work with membrane 
protein purification and experience with cryoEM data analysis is a plus. A 
successful candidate is expected to be highly skilled and self-motivated and is 
willing to work in a collaborative environment. The Postdoctoral salary depends 
on qualifications and relevant experiences according to USC standards.


Interested candidates should apply directly with Cornelius Gati at 
gati[at]usc.edu. Please attach a cover letter, Curriculum 
Vitae, research statement, publication list and a reference letter. There is no 
deadline for this posting and applications will be evaluated on a rolling basis.


Current group website: https://dornsife.usc.edu/gati/



Recent work from our group includes:


Molecular basis of anaphylatoxin binding, activation, and signaling bias at 
complement receptors.

Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, 
Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, 
Banerjee R*, Shukla AK*, Gati C*. Cell. (2023)


Structural basis of GABA reuptake inhibition.

Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C*. 
Nature. 606 (2022) 820-826


Structural basis of metabotropic GABA receptor activation.

Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, 
Gati C*, Cherezov V*. Nature. 584 (2020) 298-303


A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.

Rempel S, Gati C*, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, 
Guskov A, Slotboom DJ*. Nature. 580 (7803) (2020) 409-412



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[ccp4bb] PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles

[Cornelius Gati]

PostDoctoral Position in GPCR Structural Biology at USC, Los Angeles


The position is available starting immediately in the Department of Biological 
Sciences at the University of Southern California and is initially limited to 2 
years, with possible extension.


Our research focuses on the structural biology of G protein-coupled receptors 
involved in neurobiology and immunology, using single particle cryoEM, 
complemented with biophysical assays.


USC has a suite of research facilities and has recently commissioned a 
brand-new cryoEM facility:

• CryoEM suite: Titan Krios with GIF Quantum energy filter and K3 detector, 
Glacios with Falcon 4 detector, Talos Arctica with CCD/side entry holder for NS 
and screening
• Core facility for insect- and mammalian cell expression
• High performance computing for data processing/analysis


Qualified candidates must have a Ph.D. degree with a solid background in 
structural biology and biophysics/biochemistry. Previous work with membrane 
protein purification and experience with cryoEM data analysis is a plus. A 
successful candidate is expected to be highly skilled and self-motivated and is 
willing to work in a collaborative environment. The Postdoctoral salary depends 
on qualifications and relevant experiences according to USC standards.


Interested candidates should apply directly with Cornelius Gati at 
gati[at]usc.edu. Please attach a cover letter, Curriculum Vitae, research 
statement, publication list and a reference letter. There is no deadline for 
this posting and applications will be evaluated on a rolling basis.


Current group website: https://dornsife.usc.edu/gati/



Recent work from our group includes:


Molecular basis of anaphylatoxin binding, activation, and signaling bias at 
complement receptors.

Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, 
Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, 
Banerjee R*, Shukla AK*, Gati C*. Cell. (2023)


Structural basis of GABA reuptake inhibition.

Motiwala Z, Aduri NG, Shaye H, Han GW, Lam JH, Katritch V, Cherezov V, Gati C*. 
Nature. 606 (2022) 820-826


Structural basis of metabotropic GABA receptor activation.

Shaye H, Ishchenko A, Lam JH, Han GW, Xue L, Rondard P, Pin JP, Katritch V, 
Gati C*, Cherezov V*. Nature. 584 (2020) 298-303


A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds.

Rempel S, Gati C*, Nijland M, Thangaratnarajah C, Karyolaimos A, de Gier JW, 
Guskov A, Slotboom DJ*. Nature. 580 (7803) (2020) 409-412




To unsubscribe from the CCP4BB list, click the following link:
https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB=1

This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list 
hosted by www.jiscmail.ac.uk, terms & conditions are available at 
https://www.jiscmail.ac.uk/policyandsecurity/

[ccp4bb] Postdoctoral Position in GPCR Structural Biology and Biophysics at Sanofi (Shanghai)

[Matthias Dreyer]

A postdoctoral position is available at Sanofi RD (Shanghai, China)

About the Job:
As a member of our research team within the GPCR consortium at the iHuman 
Institute at Shanghai Tech University, the candidate will be part of an 
interdisciplinary group of researchers dedicated to advancing GPCR structural 
biology and related science for drug discovery. The candidate will be involved 
in the structural and kinetic studies of GPCR proteins. The candidate will also 
get training in drug discovery from industry and translational academic labs. 
Based on project needs, there is a possibility for the candidate to perform 
part of the work at Sanofi global research sites in the US, France or Germany. 
Publication of the study results is highly encouraged. The duration of the 
program is 2 years.

Qualifications:

-Ph.D. in structural biology, molecular biophysics, biochemistry, or a 
related field, for less than 3 Years

-Demonstrated expertise and track record in membrane protein expression 
and purification

-Experience in membrane protein crystallization

-Experience with surface plasmon resonance and/or related technologies 
is of advantage

-Strong communication skills in English, ability to work independently, 
good team player and willing to work in an interdisciplinary environment

About Sanofi (http://en.sanofi.com):
Sanofi Global RD is the Research and Development organization of Sanofi, an 
integrated, global healthcare company focused on patient needs and engaged in 
the research, development, manufacturing and marketing of healthcare products. 
Sanofi RD is a global organization of approximately 16,200 scientists 
worldwide whose everyday mission is to focus on researching new cures and new 
ways of treating disease around the world. Our research and development teams 
develop vaccines, which can save lives by the millions for children around the 
world, and treatments that save the lives of one patient with a very rare 
disease, for example.

About Asia-Pacific RD Hub 
(http://www.sanofi.cn/l/cn/zh/layout.jsp?scat=96417507-9C33-489A-BEFE-863169D29703)
Established in Shanghai in 2014, the Sanofi Asia-Pacific RD Hub (AP Hub) is 
the first to integrate capabilities in biopharmaceuticals (Sanofi Biopharma), 
rare diseases (Sanofi Genzyme), vaccines (Sanofi Pasteur) and animal health 
(Sanofi Merial) to address the region's most critical medical needs.

To Apply:
Please send your C.V. to lily@sanofi.com or 
matthias.dre...@sanofi.commailto:matthias.dre...@sanofi.com and include a 
list of publications and contact information of 3 references in the CV.

[ccp4bb] Postdoctoral position in GPCR structural biology

[Pioszak, Augen A (HSC)]

An NIH R01-funded postdoctoral position in G protein-coupled receptor 
structural biology is available in the Pioszak laboratory in the Department of 
Biochemistry and Molecular Biology at the University of Oklahoma Health 
Sciences Center.  The position will involve biochemical, pharmacological, and 
X-ray crystallographic studies of peptide-activated class B GPCRs.
The Pioszak lab is housed in the modern S.L. Young Biomedical Research Center 
on the expanding medical school campus adjacent to the downtown Oklahoma City 
area.  We have state-of-the-art equipment for protein expression and 
purification, biophysical characterization of proteins (ITC, DSC, CD), robotic 
crystallization (ARI Gryphon), and in-house X-ray data collection (Rigaku 
system), as well as access to synchrotron macromolecular crystallography beam 
lines.

Appplicants should hold a recent Ph.D. in Biochemistry, Pharmacology, or 
related area.  Experience with molecular biology techniques, protein expression 
and purification, protein-ligand interaction methods, cell culture, and X-ray 
crystallography would be an advantage, but experience in all of these areas is 
not required.  Salary to be commensurate with qualifications and experience.
To apply, please send a cover letter, CV, and the names and contact information 
for 3 references to augen-pios...@ouhsc.edumailto:augen-pios...@ouhsc.edu.
The University of Oklahoma is an Affirmative Action/Equal Opportunity Employer.

-
Augen A. Pioszak, Ph.D.
Assistant Professor
Department of Biochemistry and Molecular Biology
University of Oklahoma Health Sciences Center

Letter address (office):
975 N.E. 10th Street, BRC 462B
P.O. Box 26901
Oklahoma City, OK  73126-0901

Shipping address (lab):
975 N.E. 10th Street, BRC 464
Oklahoma City, OK  73104

Phone:  405-271-2401 Fax:  405-271-3910
Email:  augen-pios...@ouhsc.edumailto:augen-pios...@ouhsc.edu
http://www.oumedicine.com/department-of-biochemistry-and-molecular-biology/faculty/augen-pioszak-ph-d-
-

[ccp4bb] Postdoctoral position in GPCR structural biology

[Pioszak, Augen A (HSC)]

An NIH-funded postdoctoral position in GPCR structural biology is available in 
the Pioszak laboratory in the Department of Biochemistry and Molecular Biology 
at the University of Oklahoma Health Sciences Center 
(http://www.oumedicine.com/department-of-biochemistry-and-molecular-biology/faculty/augen-pioszak-ph-d-).
  Projects involve structure/function studies of soluble domains of GPCRs as 
well as full-length receptors.

The Pioszak lab is housed in the modern S.L. Young Biomedical Research Center 
on the expanding medical school campus adjacent to the vibrant downtown 
Oklahoma City area.  We have state-of-the-art equipment for protein expression 
and purification, biophysical characterization of proteins (ITC, DSC, CD), 
robotic crystallization (ARI Gryphon), and in house X-ray data collection 
(Rigaku), as well as access to macromolecular crystallography beamlines at the 
APS synchrotron.

Applicants should hold a recent Ph.D. in Biochemistry or related area.  
Experience with molecular biology techniques, protein expression and 
purification, protein-protein interaction methodologies, and X-ray 
crystallography would be an advantage.  Experience with glycoproteins and/or 
membrane proteins is desired, but is not required.  Strong motivation and a 
strong work ethic are a must.

To apply, please send a cover letter describing your interest in the position 
and previous experience, CV, and the names and contact information for 3 
references to augen-pios...@ouhsc.edu.

Best Regards,

Augie Pioszak

-
Augen A. Pioszak, Ph.D.
Assistant Professor
Department of Biochemistry and Molecular Biology
University of Oklahoma Health Sciences Center

Letter address (office):
975 N.E. 10th Street, BRC 462B  
P.O. Box 26901  
Oklahoma City, OK  73126-0901

Shipping address (lab):
975 N.E. 10th Street, BRC 464
Oklahoma City, OK  73104

Phone:  405-271-2401Fax:  405-271-3910  
Email:  augen-pios...@ouhsc.edu
http://www.oumedicine.com/department-of-biochemistry-and-molecular-biology/faculty/augen-pioszak-ph-d-
-