Dear Herman,

The absolute configuration can be determined, although very differently
from X-ray ccrystallography.

So far, two different experimental approaches have been published: 
Ma, Oleynikov, Terasaki (2017), https://doi.org/10.1038/nmat4890

and Brazda et al (2019), 10.1126/science.aaw2560 

The former is based on imaging, the latter is based on dynamical
refinement: Jansen, Tang, Zandbergen, Schenk (1998),
https://doi.org/10.1107/S0108767397010489

There is a very interesting paper by Burmester and  Schroeder
Scanning Microscopy Vol. 11, 1997 (Pages 323-334). According to this
paper, the anomalous signal in ED is actually stronger than in X-ray
crystallography. As far as I know, this has not been pursued further.

Best wishes,
Tim

P.S.: This is a response to your email to Jessica Bruhns in the thread
'quote source inquiry'. This thread has reached an overflow, so I took
the liberty to adjust the subject.

-- 
--
Tim Gruene
Head of the Centre for X-ray Structure Analysis
Faculty of Chemistry
University of Vienna

Phone: +43-1-4277-70202

GPG Key ID = A46BEE1A

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