g1,2 Nature
(2013)
Philippe Dumas De: "James Holton"
À: "CCP4BB"
Envoyé: Dimanche 22 Mars 2020 16:38:28
Objet: Re: [ccp4bb] CCP4BB vs COVID19
Thank you Patrick,
RNA structure is still structural biology, so I think relevant here. It seems
to me that RN
*À: *"CCP4BB" mailto:CCP4BB@JISCMAIL.AC.UK>>
*Envoyé: *Dimanche 22 Mars 2020 16:38:28
*Objet: *Re: [ccp4bb] CCP4BB vs COVID19
Thank you Patrick,
RNA structure is still structural biology, so I think relevant
here. It seems to me that RNA as a thermometer would be an e
For what it’s worth, I’ve spent the last few days going over most of the
existing COVID-19 related structures and rebuilding/re-refining wherever I
considered necessary. The resulting models along with some basic explanatory
notes are at
James, there are lots of quite simple experiments that would be could be
done, but I can't get anyone to think seriously about the problem - let
alone do the experiments.
The attitude seems to be, "it can't be as simple as you suggest - someone
would have noticed it".
* Has anyone measured
umas
De: "James Holton"
À: "CCP4BB"
Envoyé: Dimanche 22 Mars 2020 16:38:28
Objet: Re: [ccp4bb] CCP4BB vs COVID19
Thank you Patrick,
RNA structure is still structural biology, so I think relevant here. It seems
to me that RNA as a thermometer would be an easy hypothes
2020 16:38:28
Objet: Re: [ccp4bb] CCP4BB vs COVID19
Thank you Patrick,
RNA structure is still structural biology, so I think relevant here. It seems
to me that RNA as a thermometer would be an easy hypothesis to test? Has anyone
measured virulence vs temperature in cell culture?
The 3D
Thank you Patrick,
RNA structure is still structural biology, so I think relevant here. It
seems to me that RNA as a thermometer would be an easy hypothesis to
test? Has anyone measured virulence vs temperature in cell culture?
The 3D structure of the genome is no doublt important. I
2020 15:41:17
*To:* CCP4BB@JISCMAIL.AC.UK
*Subject:* Re: [ccp4bb] CCP4BB vs COVID19
James, this isn't conventional structural biology, but may be of
interest, and I haven't been able get any mainstream virologists to
think about it.
The protein sequences are obviously of interest, but so
y very nicely, including that key position 84
https://www.biorxiv.org/content/10.1101/2020.03.04.977736v1
Best wishes
Dan
From: CCP4 bulletin board on behalf of Patrick Shaw
Stewart
Sent: 21 March 2020 15:41:17
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb]
___
> From: CCP4 bulletin board on behalf of Patrick Shaw
> Stewart
> Sent: 21 March 2020 15:41:17
> To: CCP4BB@JISCMAIL.AC.UK
> Subject: Re: [ccp4bb] CCP4BB vs COVID19
>
>
> James, this isn't conventional structural biology, but may be of interest,
> and
: 21 March 2020 15:41:17
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] CCP4BB vs COVID19
James, this isn't conventional structural biology, but may be of interest, and
I haven't been able get any mainstream virologists to think about it.
The protein sequences are obviously of interest, but so
James, this isn't conventional structural biology, but may be of interest,
and I haven't been able get any mainstream virologists to think about it.
The protein sequences are obviously of interest, but so are the RNA
sequences at both ends of the Covid genome, which have conserved secondary
The best way against COVID19 is staying at home, staying at home, and
staying at home.
Nothing else.
On Fri, Mar 20, 2020, 5:59 PM James Holton wrote:
> You might think that as a structural biologist you won't be able to do
> much about COVID-19 anytime soon, but that is not true. Yes,
Dear James,
On Fri, Mar 20, 2020 at 03:59:01PM -0700, James Holton wrote:
> ORF8 has only one homolog in the PDB: 5o32 with 25% identity over a stretch
> of 60 residues. This homologous region contains the S84L site (Val I544 in
> 5o32). I had a quick look and appears to be a cavity-filling
21, 2020 11:12:36 AM
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] CCP4BB vs COVID19
Liz Tunbridge's lab at Oxford are offering PCR machines and expertise to help
fill the testing shortfall in the UK (see
https://www.wired.co.uk/article/coronavirus-uk-testing-key-workers<https://eu
To: CCP4BB@JISCMAIL.AC.UK
Subject: Re: [ccp4bb] CCP4BB vs COVID19
Liz Tunbridge's lab at Oxford are offering PCR machines and expertise to help
fill the testing shortfall in the UK (see
https://www.wired.co.uk/article/coronavirus-uk-testing-key-workers<https://eur03.safelinks.protection.outlook.
Liz Tunbridge's lab at Oxford are offering PCR machines and expertise to
help fill the testing shortfall in the UK (see
https://www.wired.co.uk/article/coronavirus-uk-testing-key-workers). This
is a worthy initiative, if it is accepted (logistics are the main problem).
The structural biology
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