+1 for consistent muted colors
I also think it may be helpful for labels that are manually managed stand
out in some way - perhaps a prefix or different shades of a specific color.
That way, a core dev could easily visually filter for any labels they may
need to change or care more about for a PR.
As the person who chose the colour scheme, I'll try to explain why I did it
the way I did. :)
If you look at https://github.com/python/cpython/labels you will notice all
related labels that have the same prefix are the same colour *unless* there
is a reason to make it stand out (e.g. type-security