-Caveat Lector-

>From The Sunday Times,
http://www.sunday-times.co.uk/news/pages/Sunday-Times/stiinnnws01004.html?99
9
-
September 12 1999 INNOVATION
Health

Monkeys that 'glow' could help fight genetic disorders

FLUORESCENT monkeys could hold the key to future research into genetic
diseases, writes Mark Prigg.

Researchers hope to splice the gene that makes jellyfish glow into a monkey
embryo. If successful, it will be the first time a gene has been spliced
into the embryo of another species. It is hoped the research will give
scientists a greater understanding of genetic mutations.

The team from the Oregon Regional Primate Research Center has tested several
techniques. It has already managed to make embryos composed of a few dozen
cells glow and now hopes to create baby monkeys that glow when placed under
ultraviolet light.

The team chose the jellyfish gene because it is easy to use and has already
been successfully placed into mice.

According to Anthony Chan, a researcher at the centre, some embryos
fertilised with monkey sperm carrying the jellyfish gene have now been
transferred into the wombs of surrogate rhesus monkeys.

He says: "Rhesus monkeys make a great model for human disease and we have no
qualms at all about this research - the reasons for doing it are sound and
will give us our best shot at curing genetic disease."

Researchers are using monkeys because they are genetically much closer to
humans than, say, mice, which are used to test new drugs. Mice often respond
to genetic mutations in different ways from primates. By introducing
human-disease genes into monkey embryos, the team hopes to test new drugs on
the rhesus monkeys, which react to disease in a similar way to humans.

The centre is keeping the exact number of monkeys used and the expected
delivery dates secret in case of attacks from animal-rights activists. They
have been demonstrating weekly at the centre in an attempt to stop several
other monkey-cloning experiments.

A laboratory spokeswoman says the monkey mothers are doing well and are
expected to give birth in November.

"The results of the experiment won't be known for some time after the
birth," she says. "With this kind of genetic experiment we want to wait and
see how the babies grow up before jumping to conclusions.

One of the advantages of using the jellyfish gene is that we will get an
instant result - the babies will glow from the moment they are born.

"However, how long they will survive and how they will develop are our main
questions, assuming they do glow. This is the first time this has been tried
anywhere in the world, so we just don't know what will happen.

"We are also very aware of the moral and political ramifications of the
work, so before we release the results we need to take everything into
account. But if it works this is undoubtedly going to be the best way to
study genetic disease in humans."

--
Dan S

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