-Caveat Lector-

http://www.newscientist.com/ns/19991002/newsstory10.html

Holy fire

                        Andy Coghlan

                        AN ORNAMENTAL BUSH prized by gardeners in
                        Europe and the US contains a surprise weapon
against
                        the mosquitoes spreading West Nile virus, the
brain
                        disease that has broken out in New York (p 13).
The
                        bush might also provide a cheap way for the
world's
                        poorest countries to fight filariasis, a
disfiguring
                        parasitic disease that affects 15 million people
in Africa
                        alone.

                        Oil from the summer cypress, better known as the

                        burning bush because it blushes a deep red in
autumn,
                        contains a substance which, when converted into
a
                        pheromone, can be used to lure mosquitoes to
their
                        deaths.

                        New Yorkers could have used this trick to combat
the
                        mosquitoes spreading the West Nile virus. The
virus
                        attacks the central nervous system and 3 of the
12
                        people with the illness have already died.
Another 102
                        suspected cases are being investigated. New York

                        health officials are fighting the outbreak by
killing
                        mosquitoes with conventional sprays of the
powerful
                        insecticides malathion and pyrethroid.

                        Burning bush oil might have provided a more
benign
                        solution. Researchers from Britain and Nigeria
have
                        turned oil from the plant's seeds into a
pheromone.
                        This biological messenger, which is odourless to

                        humans, could lure female mosquitoes away from
the
                        places where people live.

                        A team from the Rothamsted site of the Institute
of
                        Arable Crops Research in Harpenden,
Hertfordshire,
                        struck lucky when team leader John Pickett
noticed
                        that the burning bush makes a fatty acid
strikingly
                        similar to the pheromone that attracts the
mosquitoes
                        (Journal of Agricultural Food Chemistry, vol 47,
p
                        3411).

                        The pheromone is produced naturally when rafts
of
                        eggs are laid in stagnant water by Culex
                        quinquefasciatus, the mosquito species which
spreads
                        filariasis and is suspected of spreading West
Nile virus.
                        "It's a cue for female mosquitoes, telling them
that
                        there's a safe place where they can lay their
eggs,"
                        says Mike Birkett, a member of the Rothamsted
team.

                        The pheromone from the burning bush could have
been
                        used in New York to lure mosquitoes to their
death in
                        drums of water laced with pesticide, says
Birkett.
                        Pickett is confident that the pheromone attracts

                        females of all Culex species.

                        The team at Rothamsted has tested synthetic
versions
                        of the same pheromone, called
                        (5R,6S)-6-acetoxy-5-hexadecanolide. "It's been
tested
                        in field trials in Africa, Japan and the US, and
it works
                        every time," says Birkett. The problem is that
the
                        synthetic version is too expensive to
manufacture. So
                        instead, the team screened plants for substances
which
                        could be turned into the pheromone much more
                        cheaply.

                        It doesn't need to be purified from the oil,
making it
                        cheap and easy to handle. When Jenny Mordue of
the
                        University of Aberdeen tested the oil-based
pheromone
                        in the laboratory, she found that it attracted
female
                        mosquitoes as powerfully as the natural
substance.

                               From New Scientist, 2 October 1999

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