-Caveat Lector-

[I think Paxil is another fluorinated drug related to Prozac and
oloft.  --MS]

 http://www.nytimes.com/2001/06/08/health/08VERD.html

June 8, 2001


Jury Awards $6.4 Million in Killings Tied to Drug

By PHILIP J. HILTS

A Wyoming jury has awarded $6.4 million to the family of a man who killed
three relatives and himself after taking the antidepressant Paxil.

Though many lawsuits have claimed that antidepressants in the same class of
drugs, which includes Prozac and Zoloft, have caused suicidal or violent
behavior, this is the first case a plaintiff has won, lawyers in the case
said.  Charles F.  Preuss, a lawyer for the manufacturer, GlaxoSmithKline
said the verdict on Wednesday was a surprise.

"This issue was raised in the early 90's, and since that time all the
scientific articles have concluded that these antidepressants do not cause
suicide or homicide or suicidal thoughts," Mr.  Preuss said.  The drugs
have been shown to successfully treat depression and reduce the risk of
suicide that comes with severe depression.  The issue in lawsuits has been
whether the drugs themselves or the illnesses they are meant to treat are
to blame for patients' violent or suicidal behavior.  The drug makers say
that when a patient has become violent or suicidal, it has been because the
illness has overcome the effect of the drug and the patient's natural
inhibitions.

But researchers who have testified in the cases have said that, even though
the drugs are effective in most cases, in some patients the drugs cause
agitation and violence.

Lawyers in the Wyoming case, tried in Federal District Court in Cheyenne,
said Donald Schell, 60, visited an internist on Feb.  12, 1998, and
received a prescription for Paxil to treat depression.  The lawyers said
Mr.  Schell took two pills the next day before fatally shooting his wife,
Rita; their daughter, Deborah Tobin; and their 9-month-old granddaughter,
Alyssa; and himself.

Ms.  Tobin's husband and Mr.  Schell's sister filed a wrongful death suit
against SmithKline Beecham, which merged last year with Glaxo Wellcome to
form GlaxoSmithKline.  During the trial, the eight jurors heard that Mr.
Schell had taken Prozac years earlier for depression, but that he had
stopped taking the drug because he became agitated and experienced
hallucinations.

The family's lawyers, James E.  Fitzgerald of Cheyenne and Andy Vickery of
Houston, told the jury that the fault was not so much in the drug itself
but in the company's failure to sufficiently warn doctors and patients that
the effects of the drug could include agitation and violence.  Mr.  Vickery
said in a telephone interview that in Germany, warnings are included on the
packages of at least two drugs in this class, Prozac and Paxil.  The Prozac
package warns that the drugs could lead to suicide attempts.  The Paxil
package says a sedative should be taken with the drug.  Those warnings are
not on packages in the United States, but the insert for doctors says,
under the heading "suicide," that "close supervision of high-risk patients
should accompany initial drug therapy." In 1991, experts reviewed whether
this class of antidepressant might incite violence and concluded that it
did not and that no additional warnings should be included on packages.


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