-Caveat Lector-

Singapore Killer Bacterium on Rise

By DEAN VISSER
.c The Associated Press

SINGAPORE (AP) -- A common bacterium that causes respiratory tract infections
has evolved into a killer bug that antibiotics cannot fight in Singapore,
doctors and news reports said today.

The number of cases of streptococcus pneumoniae bacterium that proved
resistant to antibiotics shot up from 2 percent in 1991 to 43 percent in
1997, said Dr. Ling Moi Lin, a microbiologist at Singapore General Hospital.

The bacterium ``used to be very sensitive to penicillin, but is now showing
resistance to it,'' Ling told The Associated Press. ``It's also showing
resistance to new classes of antibiotics.''

The bug can infect the respiratory tract, sinuses or ears. It is most
dangerous when it spreads to the lungs and causes pneumonia, Ling said.

``It's a very common bacterium,'' the doctor said, noting that it could be
spread through the air by inhaling droplets coughed out by an infected
person.

About half of all patients over 60 die when the bacterium affects their blood
or brain, and the infection is also fatal to four out of 10 children under
the age of one, The Straits Times newspaper reported.

The newspaper quoted an article from the Annals Academy of Medicine in
Singapore, in which Associate Professor T.K. Lim warned: ``We may witness, in
the near future, the emergence of this virtually incurable `superbug' in
Singapore.''

Doctors said overuse and misuse of antibiotics had probably led to the
emergence of a bacterium resistant to drugs, a common problem with many types
of bacteria around the world.

``If people use too much of an antibiotic, this is the end result,'' Ling
said. ``The antibiotic will kill the bacteria that are most sensitive. The
ones that are left behind will learn to mutate and resist the antibiotic.''

Singapore's Health Ministry is reviewing guidelines on antibiotic use in an
attempt to combat the problem, the ministry said today in a written response
to questions.

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