> upstream finally has a Big Endian fix! (and probably it never worked before!) 
> https://github.com/samtools/htslib/pull/1023

There is no "probably": reading/writing BCF files did not work correctly 
before, still does not work with the patch that you have applied, and this was 
not tested by the test suite until February 17th.

The 1.10.2 test suite currently passes with the patch that you have applied 
because the test suite is known to be incomplete. If there are any users on 
s390x, they would be well served by updating debian/patches/big-endian to 
reflect PR #1023's final code patches as they were merged upstream, rather than 
the buggy incomplete version you currently have.

    John

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