Hi, I think the problem comes from mod_wsgi. I had the same problem when 
virtualhost listen on multiple ports.
Please look at this GH issue 
https://github.com/GrahamDumpleton/mod_wsgi/issues/206
and try this 
by 
https://github.com/GrahamDumpleton/mod_wsgi/issues/206#issuecomment-305019825 
by Dumpleton.

The real issue : *isinstance(value, uuid.UUID) is failling because of the 
use of sub interpreters.*
Details in the mod_wsgi documentation : 
http://modwsgi.readthedocs.io/en/develop/user-guides/processes-and-threading.html#python-sub-interpreters
 
and 
http://modwsgi.readthedocs.io/en/develop/configuration-directives/WSGIApplicationGroup.html.

That's what you should be looking for.

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