Re: [Felvtalk] anemia and negative IFA

2012-12-25 Thread Sharyl
Dave I would have your other cat tested.  I find it hard to believe that an 
indoor only cat suddenly tests positive.  Here is the link to a flow chart I 
found helpful to understand the test results
http://www.felineleukemia.org/felvhlth.html
 
Hope it helps
Sharyl
 


 From: David Arthurs arthurs.da...@gmail.com
To: felvtalk felvtalk@felineleukemia.org 
Sent: Tuesday, December 25, 2012 6:14 PM
Subject: [Felvtalk] anemia and negative IFA
  

Our female cat, Tux, is 5 years old and is recovering from acute anemia...we 
are 2-cat household...both house cats, not allowed outside and no exposure to 
other cats as far as we know. Both were tested at the age of spaying (~9 mos) 
for FeLV (Elisa) and were negative and vaccinated against it...and boostered 2 
years ago. 

Tux's blood chem was normal except for severe anemia (10% RBC). She had lost 2 
lbs off her normal weight (sudden)...had a positive snap test and negative IFA 
for FeLV. Her blood also tested positive for immune reaction to her own blood.  

We started treatment on prednisone and antibiotics and she has gained 1/4 pound 
and boosted her new RBC count by 5x, now RBC is at 15% by blood volume...all in 
one week's time. 

The vet is certain she has FeLV...even though we're having a hard time 
understanding how she could possibly have been exposed...and if exposed why the 
vaccine didn't prevent infection (it seems like a real long shot that she would 
have caught FeLV). I am also trying to understand how the IFA test could be 
negative...the low RBC count seems to indicate that this is secondary 
viremia...and infecting her bone marrow (which should lead to a positive IFA). 
The vet keeps suggesting implausible ways she may have caught the virus in 
order to maintain the diagnosis as FeLV. 

Please let me know your experiences and please be honest if you think we're in 
denial. From online research I've been able to determine that the snap test is 
about 90-95% reliable (and prone to technician error if faintly positive) and 
the IFA is 99.9% accurate...but may not register right away if she has an 
initial infection.


Thanks for any advice you can share. Dave

-- 
Dave Arthurs
415.518.9960 mobile
415.344.6546 office
  
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[Felvtalk] Re anemia and negative IFA (Dave)

2012-12-25 Thread Lorrie
Dave,

I'm no expert by any means, but I have had a bit of experience with
FelV as I have 16 cats at home and more in my own rescue shelter in
a building I bought in 2004 and made into a cageless sanctuary for
cats. I have several FelV cats there.

The only thing I can think of regarding Tux is that she may have been
exposed to the virus before you adopted her. It can take about 6 weeks
after exposure to the virus before the Elisa test shows a definite 
positive or negative. Anemia is something several of my FelV cats have 
died from, and a few of them were positive as long as 5 years before 
showing any symptoms. Usually positive kittens die within the first year, 
but not always. Approximately 1/3 of all positive cats carry the virus 
and never show symptoms, 1/3 die, and the other 1/3 have immune systems 
strong enough to kill the virus.  

As for the vaccine preventing FelV, if Tux had already been exposed 
before you adopted her the vaccine would not have kept her from
developing FelV.

At this time I have a litter of four 7 month old rescued kittens who 
all tested positive. There mother was feral and probably FelV positive.
Sadly, one died last week and the other three still appear very healthy.
I will retest them in a couple weeks and hopefully they will be negative.

The difference in your Elisa test and your IFA test is puzzling. You 
wrote that her blood test showed she was having an immune reaction to
her own blood, and this appears (to me) to be more of an auto-immune
problem rather than FelV.  

Please keep us updated on Tux.

Lorrie 


On 12-25, David Arthurs wrote:
Our female cat, Tux, is 5 years old and is recovering from acute
anemia...we are 2-cat household...both house cats, not allowed outside
and no exposure to other cats as far as we know. Both were tested at
the age of spaying (~9 mos) for FeLV (Elisa) and were negative and
vaccinated against it...and boostered 2 years ago.

Tux's blood chem was normal except for severe anemia (10% RBC). She had
lost 2 lbs off her normal weight (sudden)...had a positive snap test
and negative IFA for FeLV. Her blood also tested positive for immune
reaction to her own blood.

We started treatment on prednisone and antibiotics and she has gained
1/4 pound and boosted her new RBC count by 5x, now RBC is at 15% by
blood volume...all in one week's time.

The vet is certain she has FeLV...even though we're having a hard time
understanding how she could possibly have been exposed...and if exposed
why the vaccine didn't prevent infection (it seems like a real long
shot that she would have caught FeLV). I am also trying to understand
how the IFA test could be negative...the low RBC count seems to
indicate that this is secondary viremia...and infecting her bone marrow
(which should lead to a positive IFA). The vet keeps suggesting
implausible ways she may have caught the virus in order to maintain the
diagnosis as FeLV.

Please let me know your experiences and please be honest if you think
we're in denial. From online research I've been able to determine that
the snap test is about 90-95% reliable (and prone to technician error
if faintly positive) and the IFA is 99.9% accurate...but may not
register right away if she has an initial infection.
Thanks for any advice you can share. Dave
--
Dave Arthurs
415.518.9960 mobile
415.344.6546 office


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Re: [Felvtalk] Re anemia and negative IFA (Dave)

2012-12-25 Thread Dave Arthurs
Thanks for the info. We've had Tux and her litter mate, Jet, since they were 
around 6 months old. Both were tested and negative when they were spayed at 9 
months. If they were exposed it had to be 4.5 years ago and then they both had 
false negative elisa tests. 

We are going to test Jet. I'll share those results when we get them. Based on 
the flow chart we'll re-test Tux with IFA in 30 and 60 days. If those tests are 
negative then we'll accept the negative diagnosis.

Yes, the blood antibody test may indicate an auto immune disorder. This test 
will also be positive for blood-specific antigens (parasites and FeLV). We 
didn't want to take any more blood so we just started treatment for parasites 
without confirmation. The vet indicated that the antibiotic would be prescribed 
for FeLV anyway to ward off secondary infections. 

I read that elisa can be false positive for a lot of reasons. In this case 
technician error is at the top of my thoughts. I think the vet had decided on 
the diagnosis and read the elisa wrong. 

Thanks again for sharing your thoughts and experiences with FeLV. Dave

On Dec 25, 2012, at 4:00 PM, Lori felineres...@frontier.com wrote:

 Dave,
 
 I'm no expert by any means, but I have had a bit of experience with
 FelV as I have 16 cats at home and more in my own rescue shelter in
 a building I bought in 2004 and made into a cageless sanctuary for
 cats. I have several FelV cats there.
 
 The only thing I can think of regarding Tux is that she may have been
 exposed to the virus before you adopted her. It can take about 6 weeks
 after exposure to the virus before the Elisa test shows a definite 
 positive or negative. Anemia is something several of my FelV cats have 
 died from, and a few of them were positive as long as 5 years before 
 showing any symptoms. Usually positive kittens die within the first year, 
 but not always. Approximately 1/3 of all positive cats carry the virus 
 and never show symptoms, 1/3 die, and the other 1/3 have immune systems 
 strong enough to kill the virus.  
 
 As for the vaccine preventing FelV, if Tux had already been exposed 
 before you adopted her the vaccine would not have kept her from
 developing FelV.
 
 At this time I have a litter of four 7 month old rescued kittens who 
 all tested positive. There mother was feral and probably FelV positive.
 Sadly, one died last week and the other three still appear very healthy.
 I will retest them in a couple weeks and hopefully they will be negative.
 
 The difference in your Elisa test and your IFA test is puzzling. You 
 wrote that her blood test showed she was having an immune reaction to
 her own blood, and this appears (to me) to be more of an auto-immune
 problem rather than FelV.  
 
 Please keep us updated on Tux.
 
 Lorrie 
 
 
 On 12-25, David Arthurs wrote:
   Our female cat, Tux, is 5 years old and is recovering from acute
   anemia...we are 2-cat household...both house cats, not allowed outside
   and no exposure to other cats as far as we know. Both were tested at
   the age of spaying (~9 mos) for FeLV (Elisa) and were negative and
   vaccinated against it...and boostered 2 years ago.
 
   Tux's blood chem was normal except for severe anemia (10% RBC). She had
   lost 2 lbs off her normal weight (sudden)...had a positive snap test
   and negative IFA for FeLV. Her blood also tested positive for immune
   reaction to her own blood.
 
   We started treatment on prednisone and antibiotics and she has gained
   1/4 pound and boosted her new RBC count by 5x, now RBC is at 15% by
   blood volume...all in one week's time.
 
   The vet is certain she has FeLV...even though we're having a hard time
   understanding how she could possibly have been exposed...and if exposed
   why the vaccine didn't prevent infection (it seems like a real long
   shot that she would have caught FeLV). I am also trying to understand
   how the IFA test could be negative...the low RBC count seems to
   indicate that this is secondary viremia...and infecting her bone marrow
   (which should lead to a positive IFA). The vet keeps suggesting
   implausible ways she may have caught the virus in order to maintain the
   diagnosis as FeLV.
 
   Please let me know your experiences and please be honest if you think
   we're in denial. From online research I've been able to determine that
   the snap test is about 90-95% reliable (and prone to technician error
   if faintly positive) and the IFA is 99.9% accurate...but may not
   register right away if she has an initial infection.
   Thanks for any advice you can share. Dave
   --
   Dave Arthurs
   415.518.9960 mobile
   415.344.6546 office
 
 
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