Re: [Felvtalk] Re anemia and negative IFA (Dave)

2013-02-06 Thread Dave Arthurs
Update on Tux. Recap: She tested positive for felv on the snap test in December 
and negative on ifa. She is a felv vaccinated house cat that presented with 
immune mediated hemolytic anemia. She was treated with prednisolone and 
doxycycline. She responded well to treatment tho no cause was identified 
because the vet was convinced she was felv+. 

This week we retested her. Weight is up 1 lb. and red blood cell count is 
normal. Negative on ifa. The cause of her anemia is still unknown but the vet 
has let the felv diagnosis go now. 

Thank you everyone so much for all the advice. It's heartbreaking to read about 
the struggles we all go through on this forum for the love of our pets. 

When we got tux the vet tested her for felv. She said if she was positive that 
she had to be put down right away. She was very insistent. I knew in my heart 
that was wrong and wouldn't let her do it. Of course if she were suffering that 
would be different...but I could never destroy a healthy kitten. I am very 
happy to see an entire community on this forum that feels as I did (and 
reinforces what I thought was right at the time). Unfortunately most people 
will do what the vet says...and that is very sad. 

Very best wishes to everyone and your furry companions! I will stay subscribed 
to the forum because you raise a wide array of topics and I may be able to help 
someone. Thx. Dave

On Dec 28, 2012, at 5:50 PM, Beth wrote:

 Be careful about letting get too much exercise. If she is amemic she is not 
 getting enough oxygen to her cells as it is
 David Arthurs wrote:
 The official diagnosis/condition from the pathologist is immune mediated
 hemolytic anemia/IMHA. We don't know the cause yet. We're treating for
 parasites (doxycycline)...and with prednisone to suppress the immune
 response. We'll repeat the IFA in a month.
 She is responding very well to treatment...the immune response to her own
 blood has diminished, gained back 1/4 pound, her CBC increased 50% and her
 new blood cell count was up 5x. We get another blood test tomorrow. She was
 still barely below the recommended CBC for transfusion...but is doing well
 despite everything.
 She's active though she won't play. There are a couple of times she tried
 to rough-house with her sister and gave up (it was actually funny to
 watch...after a few minutes of chase, she gave up and laid on her
 back...her sister came over and gave her a very gentle little nip on the which Tux let out a whine of indignation).
 Our vet admitted some doubt about FeLV but is sticking with it for now. I
 read online that for 60% of IMHA cases it is never determined what the
 cause was. The cats did act like they had fleas about six months ago (and
 we treated, though we never saw any fleas). Tux is also the garbage
 collector...she eats everything on the it's also possible she at
 something toxic.
 Thanks again everyone. I will follow up with any new findings. Dave
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Re: [Felvtalk] Re anemia and negative IFA (Dave)

2012-12-25 Thread Dave Arthurs
Thanks for the info. We've had Tux and her litter mate, Jet, since they were 
around 6 months old. Both were tested and negative when they were spayed at 9 
months. If they were exposed it had to be 4.5 years ago and then they both had 
false negative elisa tests. 

We are going to test Jet. I'll share those results when we get them. Based on 
the flow chart we'll re-test Tux with IFA in 30 and 60 days. If those tests are 
negative then we'll accept the negative diagnosis.

Yes, the blood antibody test may indicate an auto immune disorder. This test 
will also be positive for blood-specific antigens (parasites and FeLV). We 
didn't want to take any more blood so we just started treatment for parasites 
without confirmation. The vet indicated that the antibiotic would be prescribed 
for FeLV anyway to ward off secondary infections. 

I read that elisa can be false positive for a lot of reasons. In this case 
technician error is at the top of my thoughts. I think the vet had decided on 
the diagnosis and read the elisa wrong. 

Thanks again for sharing your thoughts and experiences with FeLV. Dave

On Dec 25, 2012, at 4:00 PM, Lori wrote:

 I'm no expert by any means, but I have had a bit of experience with
 FelV as I have 16 cats at home and more in my own rescue shelter in
 a building I bought in 2004 and made into a cageless sanctuary for
 cats. I have several FelV cats there.
 The only thing I can think of regarding Tux is that she may have been
 exposed to the virus before you adopted her. It can take about 6 weeks
 after exposure to the virus before the Elisa test shows a definite 
 positive or negative. Anemia is something several of my FelV cats have 
 died from, and a few of them were positive as long as 5 years before 
 showing any symptoms. Usually positive kittens die within the first year, 
 but not always. Approximately 1/3 of all positive cats carry the virus 
 and never show symptoms, 1/3 die, and the other 1/3 have immune systems 
 strong enough to kill the virus.  
 As for the vaccine preventing FelV, if Tux had already been exposed 
 before you adopted her the vaccine would not have kept her from
 developing FelV.
 At this time I have a litter of four 7 month old rescued kittens who 
 all tested positive. There mother was feral and probably FelV positive.
 Sadly, one died last week and the other three still appear very healthy.
 I will retest them in a couple weeks and hopefully they will be negative.
 The difference in your Elisa test and your IFA test is puzzling. You 
 wrote that her blood test showed she was having an immune reaction to
 her own blood, and this appears (to me) to be more of an auto-immune
 problem rather than FelV.  
 Please keep us updated on Tux.
 On 12-25, David Arthurs wrote:
   Our female cat, Tux, is 5 years old and is recovering from acute
   anemia...we are 2-cat household...both house cats, not allowed outside
   and no exposure to other cats as far as we know. Both were tested at
   the age of spaying (~9 mos) for FeLV (Elisa) and were negative and
   vaccinated against it...and boostered 2 years ago.
   Tux's blood chem was normal except for severe anemia (10% RBC). She had
   lost 2 lbs off her normal weight (sudden)...had a positive snap test
   and negative IFA for FeLV. Her blood also tested positive for immune
   reaction to her own blood.
   We started treatment on prednisone and antibiotics and she has gained
   1/4 pound and boosted her new RBC count by 5x, now RBC is at 15% by
   blood volume...all in one week's time.
   The vet is certain she has FeLV...even though we're having a hard time
   understanding how she could possibly have been exposed...and if exposed
   why the vaccine didn't prevent infection (it seems like a real long
   shot that she would have caught FeLV). I am also trying to understand
   how the IFA test could be negative...the low RBC count seems to
   indicate that this is secondary viremia...and infecting her bone marrow
   (which should lead to a positive IFA). The vet keeps suggesting
   implausible ways she may have caught the virus in order to maintain the
   diagnosis as FeLV.
   Please let me know your experiences and please be honest if you think
   we're in denial. From online research I've been able to determine that
   the snap test is about 90-95% reliable (and prone to technician error
   if faintly positive) and the IFA is 99.9% accurate...but may not
   register right away if she has an initial infection.
   Thanks for any advice you can share. Dave
   Dave Arthurs
   415.518.9960 mobile
   415.344.6546 office
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