From: joel kehler Date: Wed, Apr 21, 2010 at 10:38 AM Subject: Re: what do you know about FeLIX To: twelvehousec...@gmail.com
I'm not exactly sure what you were reading or why you single out FeLV-C. This is my understanding of the situation, although I haven't read a lot on FeLV, and you and others may know more than I do: FeLV-A is the less pathogenic transmissible form of the virus. Mutagenesis occurs when FeLV-A recombines genetically inside feline cells (I believe with dormant atavistic remnants of genetic material from an older form of FeLV) to produce the other variants, each of which uses specific receptors to infect cells. FeLV-B particularly causes cancerous tumors. FeLV-C particularly causes the aplastic anemia characteristic of FeLV-AIDS. FeLV-T is a T-cell tropic strain. It's unclear to me if FeLV-T has a specific disease profile or not; what is clear is that it infects T lymphocytes preferentially, not unlike FIV, and causes immune deficiency. FeLIX relates specifically to FeLV-T. I did a bit of reading, and what I find is that FeLV-T uses a unique co-receptor on the T-cell it is infecting. That co-receptor has been denominated FeLIX. No other FeLV strain uses this molecule. I found FeLIX described as "a truncated envelope glycoprotein of an endogenous FeLV." However, FeLV-T requires another receptor, which is the one used by FeLV-B to infect a cell. This makes it possible for FeLV-T to infect cells already infected with FeLV-B. I did not find an association of FeLV-C and either FeLV-T or FeLIX. Maybe you have been looking at something that makes that association that I'm unaware of. If so, let me know what it is. As I said, I just dabbled for a short time. Joel --- On *Tue, 4/20/10, MaryChristine <twelvehousec...@gmail.com>* wrote: From: MaryChristine <twelvehousec...@gmail.com> Subject: what do you know about FeLIX To: "joel kehler" <joelkeh...@yahoo.com> Date: Tuesday, April 20, 2010, 4:33 PM the mutated form of the FeLV-C strain, that supposedly is what causes all the illness? i know all about FeCoV mutating into FIP, but this is a new one to me.... i'm on my way out the door, but a very quick search showed findings back in 2000, which in FeLV research is ancient--i know of too many things "discovered!!!!!" then that has since been disproven. since you have encountered more than anyone i know, thought i'd ask! MC -- Spay & Neuter Your Neighbors! Maybe That'll Make The Difference.... MaryChristine Special-Needs Coordinator, Purebred Cat Breed Rescue (www.purebredcats.org) Member, SCAT (Special-Cat Action Team) -- Spay & Neuter Your Neighbors! Maybe That'll Make The Difference.... MaryChristine Special-Needs Coordinator, Purebred Cat Breed Rescue (www.purebredcats.org) Member, SCAT (Special-Cat Action Team) _______________________________________________ Felvtalk mailing list Felvtalk@felineleukemia.org http://felineleukemia.org/mailman/listinfo/felvtalk_felineleukemia.org
