Hi Kris,
I'm sorry it took so long to write, but I've been pretty overwhelmed with illness and injury right now.  I have been following the list as best I can and I just wanted you to know how sorry I am you had to find us.  This disease is horrid, and every cat seems to be effected in different ways and degrees.  One thing I have discovered is, there is always cause for hope.  It's constantly testing my mettle, and I have found out I'm stronger and more courageous than I would have previously imagined.

As far as cross-mixing goes...  I have never found a vet, or anything in my research that suggests mixing is a good idea.  And why would they?  Of course there's less of a chance of infection if they're separated, that's common sense.  That being said, it was never an option for me to isolate any of my animals.  If my husband came down with smallpox, I wouldn't make him go live in the garage!  It may have been an easier decision for me.  When I found out mine were positive, it was long after they had become part of the family.  They had been co-mingling for so long that it didn't make sense for me to separate them at that point.  Besides they wouldn't have understood, everyone has access to everywhere and everyone else, they would have been so unhappy and confused if I had shut them away somewhere.  I know it's a risk, but it's a risk I feel compelled to take.  Based on my own experience and that of others on this list, I have since found out that the risk is much slimmer than I had been led to believe.  My FeLV+ are now 17 months old and I've had them since they were 2 1/2 weeks.  None of my other cats have become positive.  I would strongly recommend vaccinating your negatives, (be careful, in my haste to protect a semi-feral the same age as my FeLV kittens, I allowed my vet to accidently over-vaccinate her and she has IBD now).  No one can make this decision for you, you are the one who must be willing to live with the consequences, but quality of life is of the utmost importance to me, and from your posts your negative cats seem very unhappy, (so do you for that matter!).

I just read one of Sally's post about Purrki testing positive as a kitten and then recently testing negative.  I just wanted to mention that, Tim, one of the kittens from my FeLV litter, has tested negative also.  That's what I mean by there always being room for hope.  Everything I read, and I've read a lot, said that a kitten contracting FeLV inutro has a very slim prognosis for clearing the virus, but here's my Tim, handsome and strong with no signs of illness and testing negative!  It's true that it could be sequestered in his bone marrow, but I continue to treat him as if he's positive, (he gets all the supplements and close scrutiny as his sisters) and still allow myself the joy in knowing that he's tested negative.  There is also the possibility of your cats being carriers that test positive, without ever showing the ill-effects associated with the disease.  It's all such a crap-shoot, but isn't life in general that way?  That's another thing this disease has taught me, I don't have nearly the control over my environment that I once thought I did.  It's a fine line that I continue to battle.

I can't advise you about Retrovir, I'd never heard of it before you mentioned it.  I do know that, in my case, feline interferon, Doxycycline and Sally's Transfer Factors has helped my babies recover when I thought all was lost.  The most important things are to keep the household stress-free, provide good nutrition and supplements and watch them like a hawk to jump on any sign of illness before it can take hold.  If/when you do start mixing your household again, watch your negatives for illness as well, as Sally has stated they are probably bigger threats to your FeLV, than the other way around!

I'm very pleased to hear Thor is doing better.  You, Luna, Thor and the rest of your family are in my thoughts and prayers.  You're never alone.  You've found a warm, knowledgeable and supportive group of people on this list.  I don't know what I would do without them.

Nina



Kris Kulak wrote:
Wow Sally, You are extremely informative and easier to comprehend than some sites I've been too. I greatly appreciate your response. I've had the older kitten tested IFA because he was so sick at the time, I wanted a complete check-up, never thinking this would happen since all of my cats are indoor creatures. The other 4 had the ELISA because I wanted an idea right away. I was so devastated at the time, I wanted to know ASAP.
 
I do have the 3 older ones isolated to the basement and the two little guys upstairs with me where we can keep a better eye on them. I hope this is only temporary because it is extremely hard on the cats and the rest of the family. We have to sneak in and out of the door which is not easy with 5 cats trying to sneak with you. They meow or howl or scratch back and forth at the door constantly.
 
The littlest guy (Luna) is about 4 months old. He acts totally and completely normal so far. Thor, the older kitten who got his name because he was extremely loud and thundrous, was the one that got sick, but tested negative twice before. It wasn't until shortly after we got the kitten that he got sick. Sylvester, the oldest and the leader of the pack, got sick too. At first I though it was a cold, and with Sylvester it was. But Thor couldn't shake it. After three weeks more with medication not working, I took him back in. That's when his blood work came back positive. Thor was really lethargic, not eating much, sweaty, isolated, etc. Since then, I've put him on this Retrovir. I don't like the side effects that could happen, but he seems to be getting better. Just this morning he was sounding like thunder again chasing the little guy around the house. I just got home from work (the first day back since I found out he was sick; I was never so scared to come home in my life; I didn't know what to expect) and right away, he wanted to play. He meowed at me a few times. Then he threw up a nice, big, juicy fur ball right at my feet. After that, he started chasing a piece of material I was dragging on the floor.
 
He does eat a little more now. At 2 AM he woke me up hungry. I had to feed him. I sat on the floor, put soft food on my finger and rubbed in his mouth. He ate about a quarter of a can that way. He still has episodes where he stares at his food, but I rub a little on his teeth and he will eat out of my hand. Sometimes, he's even eating on his own. The nice thing though, is that he's is becoming more active and seems to be putting on more weight again. But, as I said before, I too scared to get my hopes up. I'm just hanging in there along with him.
 
I know it's not recommended, and my husband isn't even sure, but I would like to reunite my family after the incubation period is over and the cats have all been retested. I can't dream of putting the burden of raising possibly terminally ill cats onto someone else. I'd rather have the hea;thy cats go somewhere. The only problem, I am sooooo emotional. My husband worries it will "kill" me. I keep telling him that it will be hard, but for the kitties' sake, I've got to keep them where they're used to and comfortable. The least amount of stress is recommended, right?
 
I so love this group. It is helping me a lot. And I'm learning a lot. Hopefully soon, I'll be able to relax a little and stop feeling like dread is looming behind me. Thanks again.
 
Kristina

[EMAIL PROTECTED] wrote:
Dear Sally:

Did the cats test positive on both an ELISA and an IFA test? If they were
just tested with the ELISA (the in-house snap test), this test is much more
sensitive to the antigen produced by the replicating virus so it can be an
indication of an infection which may only be transitory and there is a chance the
virus can be cleared. While this is more likely with an adult cat than a kitten,
it is not impossible for a kitten who tests positive early on to later test
negative. I have one who was positive at 6 weeks but retested negative a 6 mos.
when he was neutered.

If an IFA test was not done, I would strongly urge you to do so as this can
give you an indication of what stage of infection the cats may be in and a
better idea as to their chance for long-term survival. According to Dr. Richard
Pitcairn, there are six stages of FeLV infection. The ELISA is 100 times more
sensitive so a positive result on this test can indicate the earlier stages of
infection as well as the latter ones. A positive IFA correlates well with
stage 4 and up. While it is possible for a cat in early stage to still clear the
virus, it is more likely an IFA+ cat will remain persistently viremic. It is
not until stage five that a cat is actively shedding the virus and so
infectious to others, and it takes repeated and direct contact with a cat who is
shedding the virus to result in infection. A cat persistently infected with FeLV
and immunocompromised is actually more at risk of exposure to other cats than
are healthy adult cats at risk from exposure to a cat which is infected with
FeLV. Not all FeLV+ cats are shedding the virus, and it is not the easiest
virus to transmit...it does not live long outside its host.

Kittens are most at risk of infection...not only because they have an
immature immune system but because lymphocytes in a kitten produce 50 times more
virus than those of an adult cat. Kittens infected before birth by an infected
mom, or shortly after birth through nursing or mutual grooming, have the worst
prognosis for survival. It is said around 50% won't make it through their
first year. Those that do may continue to do well until around age 2-3-4. Some
manage to live a relatively normal life span. What seems to determine this is
whether or not the relatively benign FeLV-A subgroup of the virus, which is
the only form that is passed from one cat to another, eventually recombines with
the cat's DNA and mutates into one of the more virulent subgroups. The
FeLV-A+B is the one associated with lymphomas and other cancers. The FeLV-A+C is
the one associated with severe/non-regenerative anemia. It is possible for
both mutations to occur and a cat to develop FeLV-A+B+C, which is the worst case
scenario.

If both these cats are currently non-symptomatic, there is no reason to
consider euthanasia at this point. If they can be maintained in an environment
relatively free of stress -- and that includes such stressors to the immune
system as vaccines (which can actually trigger a latent infection into an active
one), toxic drugs and toxins in poor quality food -- and fed a good quality diet
(preferably raw-based) with some immune-boosting supplements, their chance
for survival is much better than otherwise.

Some of our listmembers have cats who are 6 years and older, some have lived
into their teens. I lost my first FeLV+ furbaby at 8 mos. to non-regenerative
anemia...I did not know Purrsia was FeLV+ prior to that. Her playmate, Angel
Eyes, who was, in retrospect, probably the source of infection, tested
positive two weeks after Purrsia passed, but thrived for another seven months, then
suddenly crashed at 18 mos. and was gone 14 days later due to what was
probably lymphoma in her lungs. I currently have two more FeLV+ kittens, a brother
and sister, now 18 mos. old, who tested positive at 12 weeks and again at 6
mos. and have remained stable and non-symptomatic except for mild gingivitis.
They are on a raw-based diet and immune support with Transfer Factor, Oli-Vet.,
Vit. C, and CoQ10. My miracle baby, Purrki, was put on the same protocol
from the day I brought him home at 6 weeks with runny eyes and horrible diarrhea.
His symptoms cleared within a few days given some TF therapy, probiotics and
a homeopathic remedy for diarrhea. He has retested negative and is thriving.

If you are not able to find a permanent placement for these cats right away,
perhaps you can find someone who is willing to foster them until one can be
found? There is much than can be done to keep these kittys stable and it would
be such a shame for them to be denied a chance just because they have tested
positive. There is so much ignorance and misinformation about FeLV. Yes,
the prognosis is better for cats with FIV, but being FeLV+ should not be an
automatic death sentence. There is a liklihood the cats may not live to old age,
but it is not a given they will crash and die soon. I do hope you are able to
give them a chance to know what it is to be loved and have a home for however
long their immune systems can hold out, and perhaps may be able to clear the
virus.

Please keep us posted.

Sally in San Jose

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