Although somewhat different from the virtualization part of the subject, both...
- AMD (Secure Memory Encryption, and Memory Guard) on
both EPYC and Ryzen Pro today
and
- Intel (Multi Key Total Memory Encryption) likely on Xeon
in the near future
... also do seem to have some OS dependant bits
Just tried reinstalling the system on my laptop using the latest
available memstick snapshot
(https://download.freebsd.org/ftp/snapshots/amd64/amd64/ISO-IMAGES/13.0/FreeBSD-13.0-CURRENT-amd64-20191004-r353072-memstick.img),
using UEFI boot, and default ZFS partitioning, and it didn't boot after