Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-26 Thread Martin Juneja
External Email - Use Caution Thanks a lot Dr. Greve, that really helps. On Thu, Jul 26, 2018 at 10:45 AM, Douglas Greve wrote: > They give different results because they are supposed to. It may be that > the effect you are seeing without regressing out ICV is due to ICV, and > w

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-26 Thread Douglas Greve
They give different results because they are supposed to. It may be that the effect you are seeing without regressing out ICV is due to ICV, and when you control for ICV the effect goes away. It could also be that the ICV causes the variance to increase. This is why I asked you to check the rst

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-26 Thread Douglas Greve
If you are using surface area or volume, then you need ICV On 7/25/18 1:51 PM, Martin Juneja wrote: External Email - Use Caution Dr. Greve, I am sorry if my questions were not clear in previous email. Basically, I do not know what to conclude from this gamma comparison i.e. with and

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-25 Thread Martin Juneja
External Email - Use Caution Dr. Greve, I am sorry if my questions were not clear in previous email. Basically, I do not know what to conclude from this gamma comparison i.e. with and without ICV as covariate. Clearly, adding ICV as covariate here, is reducing effect size all ove

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-25 Thread Douglas Greve
The gammas do look different, but it is hard to tell whether they are, eg, changing sign. Not sure what you want me to comment on. On 7/24/18 2:17 PM, Martin Juneja wrote: External Email - Use Caution Just to add some more info here: The peak location of regions, X1 and X2, which I

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-24 Thread Martin Juneja
External Email - Use Caution Just to add some more info here: The peak location of regions, X1 and X2, which I found without including ICV as covariate are very close with the peak locations I found in Gamma_Without_ICV (~5.15), whereas Gamma_With_ICV is almost all over the brain (

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-24 Thread Douglas N. Greve
For noise compare the values in the rstd.mgh file, for effect size look in the gamma.mgh file On 07/24/2018 12:27 PM, Martin Juneja wrote: > > External Email - Use Caution > > Hi Dr. Greve, > > Thanks for your quick reply. Could you please give me more details how > can I check this whet

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-24 Thread Martin Juneja
External Email - Use Caution Hi Dr. Greve, Thanks for your quick reply. Could you please give me more details how can I check this whether its because of noise or its because of less CV difference? I am not sure what method/way is the best and commonly used to confirm these factor

Re: [Freesurfer] ICV as covariate for controls vs. patients

2018-07-24 Thread Douglas Greve
your results could have vanished after ICV correction for one of two reasons: the CV difference became less or the values became noisier (or a combination). So check in your data which one of those things happened. On 7/23/18 8:30 PM, Martin Juneja wrote: External Email - Use Caution

[Freesurfer] ICV as covariate for controls vs. patients

2018-07-23 Thread Martin Juneja
External Email - Use Caution Hello experts, I am interested in identifying regions of interest by comparing cortical volume (CV) between controls and patients. After including age and sex as my covariates, I identified regions X1 and X2, which showed significantly lower CV for pa