Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-13 Thread yaya ya
Hey All, I am sorry to jump into this discussion. I know how to check the slope difference between groups. I want to ask help from you to confirm that if difference in thickness in some brain areas arising from (0 0 1 -1) happens, it means that there is a group * age interaction, right? Then,

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-13 Thread Douglas N Greve
If there is no interaction, then either DODS or DOSS is appropriate. DOSS will be more powerful and a little more interpretable. If there is an interaction then DODS must be used, and the interpretation of the difference between groups becomes more problematic. Eg, if age is the covariate,

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-13 Thread amirhossein manzouri
Dear Doug, I need also to correct for Age and Years of Education by using them as nuisance covariate. Would you please explain: Why the covariates should be demeaned? Is subtracting the mean from each individual the only way of demeaning? How Qdec regress out the effect of the covariates , linear

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-13 Thread Douglas N Greve
On 01/13/2014 11:41 AM, amirhossein manzouri wrote: Dear Doug, I need also to correct for Age and Years of Education by using them as nuisance covariate. Would you please explain: Why the covariates should be demeaned? Reduces correlation with the group term and so improves efficiency. Is

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-12 Thread amirhossein manzouri
Thanks Doug and how can check if the slopes are different? On Jan 12, 2014 12:33 AM, Douglas Greve gr...@nmr.mgh.harvard.edu wrote: Use DODS to test whether the slopes differ between the three groups. If they do not, then use DOSS. doug On 1/11/14 5:03 PM, amirhossein manzouri wrote:

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-12 Thread Douglas Greve
If you have two groups and a single covariate, when you run it with mri_glmfit create a contrast with [0 0 1 -1]. In QDEC, it will be one of the default contrasts (something like do the two groups differ in slope?) doug On 1/12/14 5:31 AM, amirhossein manzouri wrote: Thanks Doug and how

[Freesurfer] DOSS or DODS

2014-01-11 Thread amirhossein manzouri
Hello all, I am using Qdec (version5.1) to study cortical thickness differences between groups having Age as nuisance covariate. I do not have assumption if the groups are different or not . Using DODS and DOSS gives me completely different results. We have three groups including 41, 39, and 24

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-11 Thread Douglas Greve
HiAmirhossein, don't use the DOSS feature in QDEC because there is a bug such that it does not always do the right thing. Sorry, I sent out an email about 8mo ago on this, but it is not easy to let people know about a bug once the bug is out there. If you want to use DOSS, use mri_glmfit

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-11 Thread amirhossein manzouri
Thanks Doug for the prompt reply. I just want to if DODS is ok to be used in my case or I should use DOSS? On Jan 11, 2014 10:56 PM, Douglas Greve gr...@nmr.mgh.harvard.edu wrote: Hi Amirhossein, don't use the DOSS feature in QDEC because there is a bug such that it does not always do the

Re: [Freesurfer] DOSS or DODS (Don't use DOSS with QDEC)

2014-01-11 Thread Douglas Greve
Use DODS to test whether the slopes differ between the three groups. If they do not, then use DOSS. doug On 1/11/14 5:03 PM, amirhossein manzouri wrote: Thanks Doug for the prompt reply. I just want to if DODS is ok to be used in my case or I should use DOSS? On Jan 11, 2014 10:56 PM,

Re: [Freesurfer] DOSS or DODS

2011-08-22 Thread Tetiana Dadakova
Hello Douglas, I did as you suggested and I got the results, but I still have difficulty understanding how exactly the choice of Design Matrix Type influences the analysis, so I have several questions: 1. When I look at thickness difference between two groups and choose age as nuisance

Re: [Freesurfer] DOSS or DODS

2011-08-22 Thread MCLAREN, Donald
For question #3; #4. #3 Any good stastistical textbook will be useful. The two that come to mind are: (a) Meyers and Wells. Research Design and Statistical A nalysis (b) Keppel and Wickens. Design and Analysis: A Researcher's Handbook (4th Edition) #4 SPM uses the General Linear Model for all

[Freesurfer] DOSS or DODS

2011-08-17 Thread Tetiana Dadakova
Dear all, I have two groups of subjects, and I want to see a difference in thickness between them controlling for age. I couldn't find any information in the literature on how the subject's brains in my groups develop with age. Therefore I can't tell whether thickness as a function of age for

Re: [Freesurfer] DOSS or DODS

2011-08-17 Thread Douglas N Greve
Hi Tanja, you should use DODS and test for a difference between the age slopes of the groups (ie, an interaction between group and age). If there are no significant interactions, you should then use DOSS to test for the difference between thicknesses. doug Tetiana Dadakova wrote: Dear all,