Hmmm...no I don't think so.  Will do and let you know

__________________________
  gaurav patel
  gauravpa...@gmail.com
  www.neurofreak.net

> On May 22, 2015, at 3:32 PM, Glasser, Matthew <glass...@wusm.wustl.edu> wrote:
> 
> Hi Gaurav,
> 
> Did you look at all 3 warpfield volumes (the second volume, Y, should contain 
> most of the info)?  
> 
> Peace,
> 
> Matt.
> 
> From: Gaurav Patel <gauravpa...@gmail.com>
> Date: Friday, May 22, 2015 at 2:28 PM
> Cc: "hcp-users@humanconnectome.org" <hcp-users@humanconnectome.org>
> Subject: Re: [HCP-Users] SBref Distortion Correction
> 
> Hi Matt… Juan is working with me at Columbia to get the topups working with 
> the HCP pipeline.  The echo spacing is the same in both scans, as is the 
> geometry we believe, though we still need to confirm that. The warpfield 
> images have no information in them that I can tell, as changing the scaling 
> of the display doesn't reveal anything.  Also the shimming should be the same 
> for all scans. The spin echo and gradient echo images look like they have the 
> same distortions after they've been rigidly realigned, so we're a little 
> puzzled as to why the topup procedure is failing. Any help would be 
> appreciated. Thanks!
> 
> _________________________
>  gaurav patel
>  gauravpa...@gmail.com
>  www.neurofreak.net
> 
> On May 22, 2015, at 3:00 PM, Glasser, Matthew <glass...@wusm.wustl.edu> wrote:
> 
>> It helps to reply to the previous e-mail chain so that all of the info on a 
>> question is in one place.  
>> 
>> Are you sure that those warp fields don’t have data in them, just a bad 
>> scaling of the display?  I don’t think the issue is with the topup 
>> configuration (we’ve never had to change that, despite using it on scanners 
>> with different field strengths).  
>> 
>> It would be good to check on what I suggested in the previous response.  
>> While it is undoubtably better to use a proper SBRef generated from the MB 
>> sequence itself, it should still be possible to do what you are doing.  It 
>> is important that using a rigid registration of the MB to the SBRef results 
>> in a very precise alignment (the images should have exactly the same 
>> distortion).  
>> 
>> Another question, do you know that your scanner used the same shim for all 
>> the scans?
>> 
>> Peace,
>> 
>> Matt.
>> 
>> From: Juan Sanchez <sanch...@nyspi.columbia.edu>
>> Date: Friday, May 22, 2015 at 8:56 AM
>> To: "hcp-users@humanconnectome.org" <hcp-users@humanconnectome.org>
>> Subject: [HCP-Users] SBref Distortion Correction
>> 
>> 
>> Let us clarify what we are doing exactly here. We are using spin-echo images 
>> with alternating phase-encoding directions in alternating runs (Topup PA and 
>> Topup AP, in our case). We also decided to use the corresponding Topup (PA 
>> or AP) as SBRef instead of an actual single-band reference image because we 
>> had issues obtaining the single-band image and because the tissue contrast 
>> in the spin-echo/Topup is pretty good (we tried using as SBRef the first 
>> frame of the multiband EPI but the spin-echo/Topup definitely works better, 
>> probably because of its improved tissue contrast). Even though using the 
>> Topups instead of a B0 map for distortion correction and using the Topup as 
>> SBRef instead of the first frame of the multiband EPI result in clear 
>> improvements, the resulting undistorted SBRef is not perfectly aligned to 
>> the anatomical images. For this reason, we think there's a problem with the 
>> procedures creating or applying the WarpField (the topup procedure or the 
>> applyward procedure that uses the WarpField to undistort the SBRef). The 
>> undistorted SBRef in an example subject from the HCP dataset looks 
>> noticeably better aligned to the anatomical image than ours. Furthermore, 
>> the WarpField.nii in that example subject looks very similar to the 
>> corresponding TopupField.nii (like a scaled version of it). In our data, in 
>> contrast, the TopupField.nii looks probably like it's supposed to look like 
>> (with some anatomical information) but the WarpField.nii is totally empty in 
>> some cases! After realizing this is the case, we think that our (main) 
>> problem may be in the topup procedure (or maybe the input images it uses or 
>> some later modification to the WarpField.nii). Could you give us any 
>> suggestions as to how to fix this issue? Maybe we need to adjust some of the 
>> configuration files that the topup procedure uses? Did you have to tweak any 
>> parameters to optimize this for your scanner? 
>> 
>> We're attaching one screencapture with the TopupField.nii and the 
>> WarpField.nii, another image showing the T2 anatomical scan, and a third 
>> image showing the SBRef (Topup in our case).
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