Hi Peka,
In the released genotyping-verified DZ twins, there actually is one M/F twin
pair, but only one, which is unexpected if our recruiting of twins were matched
to the population. Although we did not specifically exclude DZ twins discordant
in sex for HCP, we did recruit most of our twin subjects from previous twin
studies that specified same sex twins (MZ or DZ) because of potential sex
confounds in making comparisons between twins/twin types and to avoid sex being
a confound for dizygosity.
Best,
Jennifer
Jennifer Elam, Ph.D.
Scientific Outreach, Human Connectome Project
Washington University School of Medicine
Department of Neuroscience, Box 8108
660 South Euclid Avenue
St. Louis, MO 63110
314-362-9387
e...@wustl.edu<mailto:e...@wustl.edu>
www.humanconnectome.org<http://www.humanconnectome.org/>
From: hcp-users-boun...@humanconnectome.org
<hcp-users-boun...@humanconnectome.org> on behalf of Peka Savayan
<savay...@umn.edu>
Sent: Friday, August 11, 2017 10:49:13 AM
To: hcp-users@humanconnectome.org
Subject: [HCP-Users] opposite sex dizygotic twins
Hi experts,
In the final data release of 1206 subjects, out of 1113 subjects with MRI data
1053 have genetically confirmed family relations. Of those, there are 158 (79
pairs) dizygotic (DZ) twins. For all DZ pairs, twins in the pair have the SAME
sex.
However, Hulshoff Pol, Schnack et al. (J. Neuroscience 2006,
26(40):10235-10242) reported that 21 out of 58 DZ pairs (36%) were of OPPOSITE
sex within the pair.
1. Is my observation correct?
2. Can you explain the 100% SAME sex DZ within-pair twins? Can you
comment, please?
Thank you.
Peka
--
Peka Christova Savayan, PhD
Assistant Prof. Dept. Neuroscience Univ. Minnesota
Graduate program Center Cognitive Sciences Univ. Minnesota
Research Physicist Brain Sciences Center VAHCS
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