Pete,
Is the drug cleared almost completely thru renal elimination?
Otherwise, maybe a slope intercept model for CL as a function of CRCL?
TVCL=THETA(X)*(WT/70)**0.75+THETA(Y)*CRCL
The intercept is nonrenal CL according to the allometric model and the
slope according to CRCL. This
Leonid,
I usually prefer multiplicative parameterisation as well, since it is
easier to set boundaries (which is not necessary for power models, but
for multiplicative-linear models). However, boundaries on the additive
covariate models can still be set indirectly, using EXIT statements (not
as
Correction, I meant WT 50 and 75 in the example below:
75^0.75/(50^0.75)=1.36
-Original Message-
From: Ribbing, Jakob
Sent: 13 January 2009 00:50
To: nmusers@globomaxnm.com; 'Leonid Gibiansky'; Bonate, Peter
Subject: RE: [NMusers] CrcL or Cr in pediatric model
Leonid,
I usually prefer
Peter, Jakob, Leonid,
A practical example of how to deal with collinearity of age and weight
over a wide range (premature neonates to young adults) using GFR has
been recently reported (Rhodin et al 2008).
One way to overcome the somewhat imagined concern about using weight for
Clcr and
Thank you for this, Nick.
Regarding estimating separate eta for the two CL components I completely
agree with you. When I talked about a possible correlation component
between renal and non-renal CL that could not be attributed to size, my
intention was not to estimate separate random components
