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Dear Colleague, Please find information about two upcoming courses arranged by the Swedish Academy of Pharmaceutical Sciences. Introduction to Quantitative Pharmacology and PK/PD for Drug Discovery Development Scientists, Munich, Germany, September 2-3, 2010 This course

[NMusers] Significant Figures

Hi, while running a KOKA model I came across an observation and would greatly appreciate it if someone helps me understand it. When using a SIG=3, the model converges, and provides lower and upper CI bounds. All the CI bounds are positive except Q and the CV% of all parameters are within 20 %

[NMusers] Significant Figures Continuation

First, of all sorry about the last email, it somehow got sent before I could complete it. Hi, while running a KOKA model I came across an observation and would greatly appreciate it if someone helps me understand it. When using a SIG=3, the model converges, and provides lower and upper CI

RE: [NMusers] PD model

Here are my thoughts on this topic and the models: I agree with the comments made about the baseline and the method to deal with estimating the baseline pattern of QTc. But, adding up concentrations of two different drugs should be the last resort, because it assumes that the drugs

RE: [NMusers] Significant Figures Continuation

Dear Indranil, Nick Holford has posted his observation on the use of SIGDIG in Nonmem v6 to this list. You can find the results at his site: http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford/projects/sigdig. aspx If you use ADVAN 6 to 9, you may want to set TOL to a number really higher

[NMusers] transit model after IV dose?

Dear All I am interested in trying a transit model in an attempt to better describe early drug concentrations following intravenous injection (1 minute and 10 minute infusions) of a sedative-hypnotic drug. I found some examples of transit model control streams following oral administration

RE: [NMusers] Significant Figures Continuation

Dear Indranil, According to Bob Bauer's explanation of the search algorithm process in the introduction to NM7, he proposes the following general rules. Set SIGL, NSIG, and TOL such that: SIGL=TOL NSIG=SIGL/3 The SIGL is a new variable in NM7 that the user can now specify - if you are

[NMusers] Senior/Principle Modelling Simulation Position at GlaxoSmithKline (GSK)

GlaxoSmithKline (GSK) has an opening for a Senior/Principle Scientist in the Clinical Pharmacology Modelling Simulation Department in Harlow (UK) or Verona (Italy). Driving the success of GlaxoSmithKline - one of the world's leading pharmaceutical organisations - is a continual search for

[NMusers] missing table file

Dear NMusers, I'm trying to run a control stream using NONMEM6. Minimization was successful but there is one error message RMATX -1. I get the output file with obj values and other estimates but I don't have the table file. My table record is posted below: $TABLE ID TIME IPRE NOPRINT

RE: RE: [NMusers] how to implement AR residual error model in Nonmem with FOCE INT routine

If indeed the difficulty is caused by having a variable named KIND, then the character @ may be used to prevent the replacement rule from being applied: @ REAL (KIND=DPSIZE) :: T(NO) @ INTEGER (KIND=ISIZE) :: I,J See the help item for verbatim code. On Fri, 8 Jan 2010 11:57:53 -0500, Ludden,

Re: [NMusers] missing table file

Matt, WFN would not affect whether NONMEM decides to output a table file. I have never seen the error message RMATX- 1. Some errors will stop NONMEM from producing a table file. Jing, There is no such thing as a MASM listing file. I suspect you are talking about the raw NONMEM output file