Nick:
It means that a positive definiteness correction on the eta Hessian
matrix of a particular individual at a particular iteration was not
successful, but NONMEM goes ahead anyway. If it happened on an
intermediate iteration, and the error signal was not continually
repeated, then NONMEM manage
Hi,
I'm using NM7.1.2
$EST MAX=9990 NOABORT NSIG=3 SIGL=9 PRINT=1
METHOD=CONDITIONAL LAPLACIAN SLOW
$SUBR ADVAN6 TOL=6
Predictions are made using F_FLAG=0 and F_FLAG=1
I get this message I have never seen before. It happens with one
particular model that is closely related to others that run Ok.
