RE: [NMusers] Time-varing covariate

2013-08-28 Thread Mats Karlsson
Dear Alison, It may be clearer. It certainly would capture most covariate changes but on the other hand you may need to used EVID=2 even when the physiological variable change is at an observation/dose event (if you want to have the covariate values feed forward rather than backwards). Also,

Re: [NMusers] Time-varing covariate

2013-08-28 Thread Nick Holford
Alison, I think the problem with the on-line help arose because a relatively inexperienced nmuser was searching through the help to find some clues on what to do. The use of the physiological variable changes expression to describe an EVID=2 event seems to have been interpreted as something

Re: [NMusers] Time-varing covariate

2013-08-28 Thread Alison Boeckmann
Nick, Thanks for the suggestions. Stuart supplied another example in NONMEM Uses Guide VI (PREDPP) p. 57: A value of 2 indicates that the event is neither an observation nor dose event. The corresponding event is referred to as an other-type event. Examples of other-type events are: the time a