Hi Everyone,
I seem to have an install issue for 7.5.0 on Ubuntu 19.10. The install fails
when compiling with compilemsgs.txt as:
./install: error while loading shared libraries: libgfortran.so.3: cannot open
shared object file: No such file or directory
Looking at my package installer did
Hi Sumeet,
The most common with power covariate relationships is indeed covariate=0 and an
exponent that is estimated negative (or traverses into that area during
estimation). Given your problem is power function and BMI and cannot correctly
be 0 then I agree it should work. Double check that
Hi Ruben,
As I understand it the way you seem to intend it that CL takes value
THETA(1)*EXP(ETA(2)) when IOV1=1 (thus IOV2=0) from 0 to 24h, and
THETA(1)*EXP(ETA(3)) when IOV2=1 (thus IOV1=0) from 24h onwards. These are
separate occasions and do not overlap, so ETA(2) has no meaning (no
Hi Sumeet,
OFV is an objective fit of the model to the data, so generally that should be
your leading criteria. Outside of that you often have to deal with subjectivity.
However, there are quite a few caveats to relying too strongly on OFV. You
should try to avoid "chasing OFV" by testing too
Hi Ruben,
A quick response to your comment about simulations and residual error:
“Should we again sample residual error when we simulate from EBE estimates?
Or should we estimate individual parameter uncertainty from the OFIM and
use only that?”
This depends on what you question you
Hi Fanny,
Likelihood profiles are very useful to asses parameter uncertainty.
I am sure you find a tutorial somewhere how they work.
A number of software packages automate the process quite a bit.
They are usually much more computationally efficient than bootstrap.
Warm regards,
Douglas Eleveld
