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If you subtract (DATE-1) * 24 from TIME in the output file it will match TIME
in input file.
NONMEM reads DATE as a DATE data item, that’s why. I suspect you won’t have
this if you choose another column name for DATE (e.g. DAY). Note that this may
also have an effect on the estimation process
I think I would try IOV on F1 first before putting it on KA like Jean suggested
but above all I think there is an essential element missing in your code. IOV
is variability between occasions on top of inter individual variability.
So do something like:
F1=1
F1=THETA(1)*EXP(ETA(6)+BOVKA)
$OMEGA
