This is an erroneous statement by NONMEM given that convergence is not tested when EONLY=1, even when CTYPE>0, which you may ignore. It has been corrected for NM7.2.
Robert J. Bauer, Ph.D. Vice President, Pharmacometrics, R&D ICON Development Solutions 7740 Milestone Parkway Suite 150 Hanover, MD 21076 Tel: (215) 616-6428 Mob: (925) 286-0769 Email: robert.ba...@iconplc.com Web: www.iconplc.com<http://www.iconplc.com/> ________________________________ From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of De Ridder, Filip [JRDBE] Sent: Wednesday, April 04, 2012 5:51 AM To: nmusers@globomaxnm.com Subject: [NMusers] NM7.2 Importance Sampling Termination Testing Dear All, I have a question on termination testing during importance sampling. I used SAEM and IMP sequentially as follows: $EST METHOD=SAEM LAPLACE INTERACTION NBURN=3000 NITER=30000 PRINT=10 CTYPE=1 CINTERVAL=10 NOABORT $EST METHOD=IMP LAPLACE INTERACTION NITER=30 CTYPE=1 PRINT=1 ISAMPLE=20000 NOABORT EONLY=1 MAPITER=0 The IMP step completes 30 iterations with the message #TERM: OPTIMIZATION NOT COMPLETED If I look at the 30 iterations it seems odd that the termination criterium was not met - see table below. In addition, the root.cnv output file does only include information about the SAEM Burn-in, which was indeed terminated, but not on the IMP part. Any ideas? Kind regards, Filip De Ridder Janssen R&D MONITORING OF SEARCH: iteration 0 OBJ= -1040.79270825355 eff.= 18884. Smpl.= 20000. Fit.= 0.96728 iteration 1 OBJ= -1041.22721039882 eff.= 8139. Smpl.= 20000. Fit.= 0.90861 iteration 2 OBJ= -1040.90636254178 eff.= 7960. Smpl.= 20000. Fit.= 0.90691 iteration 3 OBJ= -1041.44226717287 eff.= 7998. Smpl.= 20000. Fit.= 0.90717 iteration 4 OBJ= -1040.95071538084 eff.= 8008. Smpl.= 20000. Fit.= 0.90724 iteration 5 OBJ= -1041.22419150397 eff.= 7998. Smpl.= 20000. Fit.= 0.90730 iteration 6 OBJ= -1041.57239188217 eff.= 8010. Smpl.= 20000. Fit.= 0.90739 iteration 7 OBJ= -1041.09660100136 eff.= 8016. Smpl.= 20000. Fit.= 0.90735 iteration 8 OBJ= -1041.25562857940 eff.= 7993. Smpl.= 20000. Fit.= 0.90713 iteration 9 OBJ= -1041.41360999108 eff.= 8019. Smpl.= 20000. Fit.= 0.90745 iteration 10 OBJ= -1041.56018094091 eff.= 8005. Smpl.= 20000. Fit.= 0.90728 iteration 11 OBJ= -1041.02520618588 eff.= 7990. Smpl.= 20000. Fit.= 0.90733 iteration 12 OBJ= -1041.45539992459 eff.= 8011. Smpl.= 20000. Fit.= 0.90739 iteration 13 OBJ= -1041.93095864456 eff.= 8001. Smpl.= 20000. Fit.= 0.90728 iteration 14 OBJ= -1041.52589661482 eff.= 8016. Smpl.= 20000. Fit.= 0.90760 iteration 15 OBJ= -1041.48177246391 eff.= 7985. Smpl.= 20000. Fit.= 0.90717 iteration 16 OBJ= -1041.41608562484 eff.= 8036. Smpl.= 20000. Fit.= 0.90746 iteration 17 OBJ= -1041.09827194526 eff.= 7990. Smpl.= 20000. Fit.= 0.90714 iteration 18 OBJ= -1041.41267372704 eff.= 8015. Smpl.= 20000. Fit.= 0.90739 iteration 19 OBJ= -1041.24437170124 eff.= 8003. Smpl.= 20000. Fit.= 0.90723 iteration 20 OBJ= -1041.38502319648 eff.= 8003. Smpl.= 20000. Fit.= 0.90725 iteration 21 OBJ= -1041.60595559575 eff.= 8018. Smpl.= 20000. Fit.= 0.90725 iteration 22 OBJ= -1041.07447863555 eff.= 7995. Smpl.= 20000. Fit.= 0.90725 iteration 23 OBJ= -1044.02744029407 eff.= 8024. Smpl.= 20000. Fit.= 0.90726 iteration 24 OBJ= -1041.26147186940 eff.= 7994. Smpl.= 20000. Fit.= 0.90749 iteration 25 OBJ= -1041.02132091032 eff.= 8010. Smpl.= 20000. Fit.= 0.90723 iteration 26 OBJ= -1041.69960672796 eff.= 8002. Smpl.= 20000. Fit.= 0.90728 iteration 27 OBJ= -1041.11216053314 eff.= 7989. Smpl.= 20000. Fit.= 0.90729 iteration 28 OBJ= -1041.18001151427 eff.= 8027. Smpl.= 20000. Fit.= 0.90741 iteration 29 OBJ= -1041.52777622052 eff.= 8009. Smpl.= 20000. Fit.= 0.90746 iteration 30 OBJ= -1041.76570085815 eff.= 8005. Smpl.= 20000. Fit.= 0.90726 ICON plc made the following annotations. ------------------------------------------------------------------------------ This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. If you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that ICON plc can arrange for proper delivery, and then please delete the message. Thank You, ICON plc South County Business Park Leopardstown Dublin 18 Ireland Registered number: 145835
