RE: [NMusers] Two compartment model with fixed omega parameters

2017-06-28 Thread Rik Schoemaker
Rik From: Waroonrat Sukarnjanaset [mailto:waroon...@hotmail.com] Sent: 28 June 2017 11:49 To: Rik Schoemaker Cc: nmusers@globomaxnm.com Subject: Re: [NMusers] Two compartment model with fixed omega parameters Dear Martin and Rik, Thank you so much for your helpful suggestions, I really appre

Re: [NMusers] Two compartment model with fixed omega parameters

2017-06-28 Thread Waroonrat Sukarnjanaset
: Tuesday, June 27, 2017 11:29 AM To: Waroonrat Sukarnjanaset Cc: nmusers@globomaxnm.com Subject: RE: [NMusers] Two compartment model with fixed omega parameters Dear Waroonrat, I fully support Martin’s suggestions below, but to come back to your original question: the fact that IIVs are set

RE: [NMusers] Two compartment model with fixed omega parameters

2017-06-27 Thread Rik Schoemaker
June 2017 11:30 To: Waroonrat Sukarnjanaset Cc: nmusers@globomaxnm.com Subject: RE: [NMusers] Two compartment model with fixed omega parameters Dear Waroonrat, To know if a model “adequately describe the data” you need to study model diagnostics. Read more for example here: http://onlinelibra

RE: [NMusers] Two compartment model with fixed omega parameters

2017-06-27 Thread Martin Bergstrand
, Martin Bergstrand, Ph.D. Senior Consultant Pharmetheus AB *From:* owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Waroonrat Sukarnjanaset *Sent:* Tuesday, June 27, 2017 10:52 AM *To:* nmusers@globomaxnm.com *Subject:* [NMusers] Two compartment model with fixed

[NMusers] Two compartment model with fixed omega parameters

2017-06-27 Thread Waroonrat Sukarnjanaset
Dear NMusers, I have tried to find an appropriate base model. I found that two compartment model with fixed Omega of V2 and Omega of Q = 0 (AIC 1860.17) provided smaller AIC than one compartment model (AIC 1921.83) did. >From these findings (no variability on V2 and Q), is it suggesting that on