-Original Message-
From: Leonid Gibiansky [mailto:lgibian...@quantpharm.com] Sent:
Tuesday, April 14, 2009 9:06 PM
To: Mats Karlsson
Cc: 'Satyendra Suryawanshi'; nmusers@globomaxnm.com
Subject: Re: [NMusers] VPC with Mixture Model
Hi Mats,
Could you elaborate why you would not stratify
: [NMusers] VPC with Mixture Model
Hi,
I realized after I sent the comment below about mixture model
**simulations** that Mats was no doubt referring to the problem of
separating the two sub-populations in the **observed** data using
MIXEST. This will of course be problematic for generating
Dear all,
I have a Mixture Model with 2 subpopulation. Now I want to check its
prediction. One way to see this is a Visual Predictive Check. My question
is, How to perform visual predictive check with mixture model?
I will be thankful for your suggestion and references.
Best regards
@globomaxnm.com
Subject: [NMusers] VPC with Mixture Model
Dear all,
I have a Mixture Model with 2 subpopulation. Now I want to check its
prediction. One way to see this is a Visual Predictive Check. My question
is, How to perform visual predictive check with mixture model?
I will be thankful
University
Box 591
751 24 Uppsala Sweden
phone: +46 18 4714105
fax: +46 18 471 4003
*From:* owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Satyendra Suryawanshi
*Sent:* Tuesday, April 14, 2009 6:50 PM
*To:* nmusers@globomaxnm.com
*Subject:* [NMusers] VPC
, April 14, 2009 9:06 PM
To: Mats Karlsson
Cc: 'Satyendra Suryawanshi'; nmusers@globomaxnm.com
Subject: Re: [NMusers] VPC with Mixture Model
Hi Mats,
Could you elaborate why you would not stratify based on the
subpopulations? It seems perfectly reasonable for me to simulate from
the model
: [NMusers] VPC with Mixture Model
Mats,
A VPC relies on simulation alone - there is no estimation step.
Presumably if the population estimate of the % of poor metabolizers is
5% then NONMEM will simulate 5% of the population as a poor metaboliser.
There is no Bayesian 'posthoc' step hidden
