RE: [NMusers] General question on modeling

2007-03-20 Thread Mark Sale - Next Level Solutions
Subject: Re: [NMusers] General question on modeling From: Nick Holford [EMAIL PROTECTED] Date: Mon, March 19, 2007 9:36 pm To: nmusers@globomaxnm.com Mark, Reality is that the vast majority of providers couldn't deal with renal function as a continuous variable in dosing. Writing

Re: [NMusers] General question on modeling

2007-03-19 Thread AJ Rossini
I'd highly recommend reading Frank Harrell's book on Regression Modeling if you think that stepwise regression makes any sense. While much of the book applies to linear and generalized linear (i.e. categorical, etc) regression models, nonlinear models (and mixed effects models) would

Re: [NMusers] General question on modeling

2007-03-19 Thread Nick Holford
Solutions, LLC www.NextLevelSolns.com Original Message Subject: RE: [NMusers] General question on modeling From: Stephen Duffull [EMAIL PROTECTED] Date: Mon, March 19, 2007 5:52 pm To: 'Mark Sale - Next Level Solutions' [EMAIL PROTECTED] Cc: nmusers@globomaxnm.com

RE: [NMusers] General question on modeling

2007-03-19 Thread Stephen Duffull
Mark hence engineering). Reality is that the vast majority of providers couldn't deal with renal function as a continuous variable in dosing. I very much hope that this is a misinformed perception by industry rather than a reality. Presumably weight is considered continuous and in