-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Nick Holford
Sent: Friday, July 25, 2008 5:14 PM
To: nmusers
Subject: Re: FW: [NMusers] PPC
Matt,
Thanks for your comments which I almost completely agree with.
You propose to log transform the parameters so
complicated.
Matt
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On
Behalf Of Nick Holford
Sent: Friday, July 25, 2008 2:12 AM
To: nmusers@globomaxnm.com
Subject: Re: FW: [NMusers] PPC
Mahesh,
Thanks for your further info on VPC and PPC. I agree
To: Nick Holford; nmusers@globomaxnm.com
Subject: RE: FW: [NMusers] PPC
Hi Nick,
I have been following this discussion and I think it is very helpful to
many of us. Can you please elaborate on that last part about binning?
What is that for? I must have missed something there.
Thanks,
Susan
PROTECTED] [mailto:[EMAIL PROTECTED] On
Behalf Of Nick Holford
Sent: Friday, July 25, 2008 2:12 AM
To: nmusers@globomaxnm.com
Subject: Re: FW: [NMusers] PPC
Mahesh,
Thanks for your further info on VPC and PPC. I agree that the bootstrap
distribution of the parameters is probably better than
VPC
be enough for model verification?
Kindly advise...Mahesh
-Original Message-
From: [EMAIL PROTECTED]
[mailto:[EMAIL PROTECTED] Behalf Of Willavize, Susan A
Sent: Wednesday, July 23, 2008 8:38 AM
To: Nick Holford; nmusers@globomaxnm.com
Subject: RE: FW: [NMusers] PPC
Hi Nick,
I
Mohamed,
When the number of subjects is small then any confidence interval is
going to be wide and probably no-one is really interested in it. With
studies more suitable for population analysis (at least 25 subjects and
preferably over 100 if you want to look for covariate effects) then the
Paul,
The procedure you describe is a way of producing a posterior predictive
check but I don't know of any good examples of its use. A simpler way of
doing a PPC samples the population parameter estimates from a
distribution centered on the final estimates with a variance-covariance
based
-mail is classified as Pfizer Confidential; it is confidential and
privileged.
-Original Message-
From: [EMAIL PROTECTED] [mailto:[EMAIL PROTECTED]
On Behalf Of Nick Holford
Sent: Wednesday, July 23, 2008 6:32 AM
To: nmusers@globomaxnm.com
Subject: Re: FW: [NMusers] PPC
Paul
PROTECTED] Behalf Of Willavize, Susan A
Sent: Wednesday, July 23, 2008 8:38 AM
To: Nick Holford; nmusers@globomaxnm.com
Subject: RE: FW: [NMusers] PPC
Hi Nick,
I have been following this discussion and I think it is very helpful to
many of us. Can you please elaborate on that last part about binning
