Re: [NMusers] unidentified cause of "F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN)"

I think this is overkill to have 10 occasions, and this could be a problem. Try to start first with 2 occasions (e.g, first 5 doses and the rest). If this works it means that it is just a numerical problem. Also, just to check, try Y=LOG(F+0.0001)+EPS_EXP to remove the possibility of F=0.

RE: [NMusers] unidentified cause of "F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN)"

Matthew, I'm guessing this error occurs because you fix the $OMEGA BLOCK(1) for ETA_CL_OCC1 to 0. The way the model is parameterized, to get rid of the IOV, you only need to fix the OMG_CL_OCC to 0 in the $THETA block, and leave the $OMEGA BLOCK(1) for ETA_CL_OCC1 alone (fixed to 1). Agree

[NMusers] RE: NONMEM 7.4.2 is now available

Dear nmusers: The password to unzip NONMEM 7.4.2 files is the same for that of NONMEM 7.4.1 and NONMEM 7.4.0. So if you remember it or wrote it down, you can use it, otherwise, request the password from Lisa Wilhelm-Lear at idssoftw...@iconplc.com. Your

[NMusers] unidentified cause of "F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A NUMBER (NAN)"

Dear nmusers, I have trouble figuring out the cause of the error I am encountering: 0INDIVIDUAL NO. 1 ID= 2.00E+00 (WITHIN-INDIVIDUAL) DATA REC NO. 2 ... OCCURS DURING SEARCH FOR ETA AT INITIAL VALUE, ETA=0 F OR DERIVATIVE RETURNED BY PRED IS INFINITE (INF) OR NOT A