Dear NONMEM users,
I'm struggling for a couple of weeks against contradictory results between
NONMEM and R analysis of the same data with the same model which includes a
time-varying bioavailability. Here is a simplified example of my issue:
On the one hand, let's introduce a bicompartmental
could you show equations? Bioavailability is treated differently in
Nonmem and R, so code should reflect it.
Thanks
Leonid
On 2/11/2020 3:52 AM, Le Louedec Felicien wrote:
Dear NONMEM users,
I’m struggling for a couple of weeks against contradictory results
between NONMEM and R analysis of
Please find below the code for NONMEM analysis and for mrgsolve which is the
package I use to perform simulations in R
Thanks you very much
Félicien
;NONMEM CODE;;;
$PROBLEM TEST F DECREASE
$INPUT ID TIME EVID AMT CMT DV MDV TOLD
$DATA ds_sim_told.csv IGNORE=@
$SUBROUTINES ADVAN13 TOL=4
could you try models without ALAG? will they also differ? Not sure how
MRGsolve treats time-dependent covariates for F1. Nonmem will use the
next value of TOLD. In this case, TOLD at dose records should be equal
to the time of the previous dose (assuming that ALAG < inter-dose
interval), is
Pls check what you have compared. You have used sigma 1 for nonmem not for
mrgsolve.
Even if you use sigma q for Mrgsolve, the results will be
slightly different due to fittong vs. Simulation via random numbers.
Hope it helps
On Tue, Feb 11, 2020, 10:43 AM Le Louedec Felicien <
Can you please share the ds_sim_told.csv file (or at least 2 complete
individuals from that file)? It does seem like TOLD is the critical thing
here, but I'd like to know what exactly is the discrepancy. IMO we need
the input data to figure that out. mrgsolve does read covariates from the
next
Hi Belo,
I suspect you have tried to run this code using NM-TRAN and NONMEM. NM-TRAN
does not know about the $FINEDATA record.
You need to run this code using the finedata.exe in the NONMEM util directory.
Best wishes,
Nick
--
Nick Holford, Professor Clinical Pharmacology
Dept Pharmacology &
Hello Nonmem Users,
When I try to use $FINEDATA, I receive the following error message:
AN ERROR WAS FOUND ON LINE 160 AT THE APPROXIMATE POSITION NOTED:
$FINEDATA TSTART=0 TSTOP=126 TDELTA=0.25 AXIS=TIME(LIN) CMT=2
FILE=K_3RD001MCORR_MSAEM_PEDIATRIC1_ERmsf.FI
X
THE CHARACTERS IN
